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Prof. Dr. Martin Fuhrmann


German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1/99 53127 Bonn

+49 228 43302480


My research focuses on neurologic and neurodegenerative diseases, like Alzheimer’s disease. I am interested in how the immune system interacts with the central nervous system. How do microglia – innate immune cells in the brain – interact with synapses and neurons, and how do the influence each other? Are microglia relevant for learning and memory and if so, how do they exert this function? To address these and other questions, we apply cutting edge multiphoton-based in vivo imaging methods in my lab. For example, it enables us to study neuronal activity in conjunction with microglia motility. In combination with optogenetic, chemogenetic, immunohistochemical, electrophysiological and behavior tests, we are able to causally link behavior to neuronal activity in brain regions relevant for learning and memory.

Recent publications

  • Aberrant hippocampal Ca micro-waves following synapsin-dependent adenoviral expression of Ca indicators.

    bioRxiv : the preprint server for biology

    Authors: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel, Tony Kelly

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  • Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation.

    Neurobiology of disease

    Authors: Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefer

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  • Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice.


    Authors: Felix Christopher Nebeling, Stefanie Poll, Lena Christine Justus, Julia Steffen, Kevin Keppler, Manuel Mittag, Martin Fuhrmann

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