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Prof. Dr. Martin Fuhrmann

Member

German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1/99 53127 Bonn

martin.fuhrmann@dzne.de

+49 228 43302480

Website

My research focuses on neurologic and neurodegenerative diseases, like Alzheimer’s disease. I am interested in how the immune system interacts with the central nervous system. How do microglia – innate immune cells in the brain – interact with synapses and neurons, and how do the influence each other? Are microglia relevant for learning and memory and if so, how do they exert this function? To address these and other questions, we apply cutting edge multiphoton-based in vivo imaging methods in my lab. For example, it enables us to study neuronal activity in conjunction with microglia motility. In combination with optogenetic, chemogenetic, immunohistochemical, electrophysiological and behavior tests, we are able to causally link behavior to neuronal activity in brain regions relevant for learning and memory.

Martin_Fuhrmann

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Recent publications

  • Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone.

    Immunity

    Authors: Felix C Nebeling, Falko Fuhrmann, Manuel Mittag, Fabrizio Musacchio, Henrike Antony, Nala Gockel, Lea L Friker, Sonia Leonardelli, Severin Filser, Deli A, Miriam Stork, Daniele Bano, Torsten Pietsch, Frank A Giordano, Qihui Zhou, Simona Parrinello, Michael Hölzel, Ulrich Herrlinger, Paolo Salomoni, Martin Fuhrmann

  • Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling.

    Cell reports

    Authors: Nala Gockel, Nayadoleni Nieves-Rivera, Mélanie Druart, Külli Jaako, Falko Fuhrmann, Fabrizio Musacchio, Henrike Antony, Manuel Mittag, Sophie Crux-Daseking, Stefanie Poll, Baiba Jansone, Martin Fuhrmann, Corentin Le Magueresse

  • Aberrant hippocampal Ca microwaves following synapsin-dependent adeno-associated viral expression of Ca indicators.

    eLife

    Authors: Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel, Tony Kelly

All publications by Prof. Dr. Martin Fuhrmann