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Prof. Dr. Martin Fuhrmann

Member

German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1/99 53127 Bonn

martin.fuhrmann@dzne.de

+49 228 43302480

Website

My research focuses on neurologic and neurodegenerative diseases, like Alzheimer’s disease. I am interested in how the immune system interacts with the central nervous system. How do microglia – innate immune cells in the brain – interact with synapses and neurons, and how do the influence each other? Are microglia relevant for learning and memory and if so, how do they exert this function? To address these and other questions, we apply cutting edge multiphoton-based in vivo imaging methods in my lab. For example, it enables us to study neuronal activity in conjunction with microglia motility. In combination with optogenetic, chemogenetic, immunohistochemical, electrophysiological and behavior tests, we are able to causally link behavior to neuronal activity in brain regions relevant for learning and memory.

Martin_Fuhrmann

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Recent publications

  • CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser-Induced Lesions.

    Glia

    Authors: Jens Wagner, Henrike Antony, Cornelia Hoyer, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann

  • Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

    Nature neuroscience

    Authors: Xin Yan, Christina Georgopoulou, Hang-Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao, Shobhit Agrawal, Sophie Crux, Andrew W Daman, Lena Wischhof, Miriam Stork, Margit Zweyer, Emma Dorotea Zanfi, Manon Chevallot-Beroux, Yunxiao Li, Elena De-Domenico, Dina Hüsson, Lorenzo Bonaguro, Yuanfang Li, Jonas Schulte-Schrepping, Qingyi Liang, Ketty Kessler, Dan Ehninger, Shahin Rafii, Jiankai Luo, Andreas Hermann, Annett Halle, Ying Liu, Elvira Mass, Melania Capasso, Hiroki Kato, Joachim L Schultze, Pierluigi Nicotera, Daniele Bano, Steven Zvi Josefowicz, Martin Fuhrmann, Thomas Ulas, Marc Beyer, Juntang Lin, Monique M B Breteler, N Ahmad Aziz, Paolo Salomoni

  • PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities.

    Nature methods

    Authors: Ryan Fink, Shosei Imai, Nala Gockel, German Lauer, Kim Renken, Jonas Wietek, Paul J Lamothe-Molina, Falko Fuhrmann, Manuel Mittag, Tim Ziebarth, Annika Canziani, Martin Kubitschke, Vivien Kistmacher, Anny Kretschmer, Eva Sebastian, Jana Ottens, Dietmar Schmitz, Takuya Terai, Jan Gründemann, Sami I Hassan, Tommaso Patriarchi, Andreas Reiner, Martin Fuhrmann, Robert E Campbell, Olivia Andrea Masseck

All publications by Prof. Dr. Martin Fuhrmann