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Prof. Dr. Martin Fuhrmann

Member

German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1/99 53127 Bonn

martin.fuhrmann@dzne.de

+49 228 43302480

Website

My research focuses on neurologic and neurodegenerative diseases, like Alzheimer’s disease. I am interested in how the immune system interacts with the central nervous system. How do microglia – innate immune cells in the brain – interact with synapses and neurons, and how do the influence each other? Are microglia relevant for learning and memory and if so, how do they exert this function? To address these and other questions, we apply cutting edge multiphoton-based in vivo imaging methods in my lab. For example, it enables us to study neuronal activity in conjunction with microglia motility. In combination with optogenetic, chemogenetic, immunohistochemical, electrophysiological and behavior tests, we are able to causally link behavior to neuronal activity in brain regions relevant for learning and memory.

Martin_Fuhrmann

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Recent publications

  • PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities.

    Nature methods

    Authors: Ryan Fink, Shosei Imai, Nala Gockel, German Lauer, Kim Renken, Jonas Wietek, Paul J Lamothe-Molina, Falko Fuhrmann, Manuel Mittag, Tim Ziebarth, Annika Canziani, Martin Kubitschke, Vivien Kistmacher, Anny Kretschmer, Eva Sebastian, Jana Ottens, Dietmar Schmitz, Takuya Terai, Jan Gründemann, Sami I Hassan, Tommaso Patriarchi, Andreas Reiner, Martin Fuhrmann, Robert E Campbell, Olivia Andrea Masseck

  • Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone.

    Immunity

    Authors: Felix C Nebeling, Falko Fuhrmann, Manuel Mittag, Fabrizio Musacchio, Henrike Antony, Nala Gockel, Lea L Friker, Sonia Leonardelli, Severin Filser, Deli A, Miriam Stork, Daniele Bano, Torsten Pietsch, Frank A Giordano, Qihui Zhou, Simona Parrinello, Michael Hölzel, Ulrich Herrlinger, Paolo Salomoni, Martin Fuhrmann

  • Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling.

    Cell reports

    Authors: Nala Gockel, Nayadoleni Nieves-Rivera, Mélanie Druart, Külli Jaako, Falko Fuhrmann, Fabrizio Musacchio, Henrike Antony, Manuel Mittag, Sophie Crux-Daseking, Stefanie Poll, Baiba Jansone, Martin Fuhrmann, Corentin Le Magueresse

All publications by Prof. Dr. Martin Fuhrmann