Skip to main content
News Icon

Publication

Artificial Intelligence Tracks down Leukemia

Artificial intelligence can detect one of the most common forms of blood cancer - acute myeloid leukemia (AML) - with high reliability. Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have now shown this in a proof-of-concept study. Their approach is based on the analysis of the gene activity of cells found in the blood. Used in practice, this approach could support conventional diagnostics and possibly accelerate the beginning of therapy. The research results have been published in the journal “iScience”.

Cluster member and speaker of the Cluster of Excellence Prof. Joachim Schultze led the study in Bonn.

Publication

Scalable prediction of acute myeloid leukemia using high-dimensional machine learning and blood transcriptomics; Stefanie Warnat-Herresthal, Konstantinos Perrakis et al., iScience (2019),
DOI: 10.1016/j.isci.2019.100780

Related news

18062025_Mass_Nature_Figure Hepatozyten

Publication

How obesity also affects the next generation

—Children born to obese mothers are at higher risk of developing metabolic disorders, even if they follow a healthy diet themselves. A new study from the group of Elvira Mass at the University of Bonn offers an explanation for this phenomenon. In obese mice, certain cells in the embryo’s liver are reprogrammed during pregnancy. This leads to long-term changes in the offspring’s metabolism. The researchers believe that these findings could also be relevant for humans. The study has now been published in the journal Nature.
View entry
Microglia interacting with T cells in the central nervous system of SPG15-deficient mice

Publication

Immune Cells Drive Congenital Paralysis Disease

—Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages of this rare hereditary disease the brain appears to play a major role by over-activating the immune system, as shown by a recent study published in the Journal of Experimental Medicine. The study was led by researchers at the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE). These findings could also be relevant for Alzheimer's disease and other neurodegenerative conditions.
View entry
Scientists that contributed to the study

Publication

New way to prevent duodenal cancer

—People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn have now discovered a mechanism in the local immune system that can drive the development of cancer. They see this as a promising new approach to preventing duodenal carcinoma in people with FAP. The results have now been published in the journal "Nature Communications".
View entry

Back to the news overview