The German Society for Orthopaedic Rheumatology (DGORh) awards the Arthur Vick Prize annually. The award serves to promote research in the field of orthopaedic rheumatology. The prize is endowed with 7,000 euros.
Dr. Robert Ossendorff was awarded the Arthur Vick Prize 2024 at the German Rheumatology Congress for his work “Immunomodulatory potential of mesenchymal stromal cell-derived extracellular vesicles in chondrocyte inflammation”.
Inflammatory processes play an important role in joints in rheumatic and chronic inflammatory degenerative diseases such as osteoarthritis. These lead to a disturbed homeostasis, which increases cartilage degradation and inhibits regenerative processes. Extracellular vesicles of mesenchymal stem cells (MSC) are membrane-enveloped vesicles that play a key role as signal transmitters. Functional phenotypic differences of MSC populations may have an impact on the therapeutic potential of MSC-EVs. As part of the BONFOR Gerok grant and the Cluster of Excellence ImmunoSensation2, a comprehensive systematic evaluation of the influence of MSC-EVs on the regeneration potential of cartilage cells in an inflammatory environment was carried out in the research laboratory of the Department of Orthopaedics and Trauma Surgery under the direction of Prof. Frank Schildberg.
Dr. Robert Ossendorff was awarded the Arthur Vick Prize 2024 at the German Rheumatology Congress for his work “Immunomodulatory potential of mesenchymal stromal cell-derived extracellular vesicles in chondrocyte inflammation”.
Inflammatory processes play an important role in joints in rheumatic and chronic inflammatory degenerative diseases such as osteoarthritis. These lead to a disturbed homeostasis, which increases cartilage degradation and inhibits regenerative processes. Extracellular mesenchymal stem cell (MSC) vesicles are membrane-encapsulated cells that are able to regenerate cartilage cells in an inflammatory environment. The resulting work was successfully published in the journal Frontiers in Immunology (DOI: 10.3389/fimmu.2023.1198198) in 2023.
The award underlines the great importance of translational research, which is supported by the Clinical Scientist Program at the UKB as part of the BONFOR instruments.
