Skip to main content

Liver cells and western diet - regulating inflammation

A high fat Western-style diet leads to hepatic steatosis that can progress to liver cancer. Christoph Thiele (LIMES Institute) from the Cluster of Excellence ImmunoSensation and his colleagues used click chemistry-based metabolic tracing and microscopy, to study the interaction between Kupffer cells and hepatocytes ex vivo. The mechanism that leads to the development of steatosis upon nutritional overload is complex and only partially understood. Their study was recently published in the Journal of Cells and could show that inflammatory signals from liver cells upon western diet can lead to steatosis. The publication was shown on the cover of the journals edition in October.

Publication

Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation. Diehl et al., Cells (2020) 9(10), 2258, https://doi.org/10.3390/cells9102258

Related news

25 Millionen Euro für die Bonner KI-Krebsforschung: (v.l.) Prof. Dr. Bernd Weber, Prof. Dr. Michael Hölzel, Prof. Dr. Jürgen Bajorath und Prof. Dr. Uwe Reuter, beim Auftakt von AI4CancerCure.NRW in der Staatskanzlei Nordrhein-Westfalen.

Honors & Funding

€25 Million for AI-Powered Cancer Research in Bonn

—University Hospital Bonn (UKB), the University of Bonn and the Lamarr Institute for Machine Learning and Artificial Intelligence are using funding from the state of North Rhine-Westphalia to establish a joint research infrastructure. The aim is to use AI to design and optimize potential cancer therapeutics and subsequently test them in the laboratory. Minister-President Hendrik Wüst and Minister of Science Ina Brandes presented the funding commitment today at the State Chancellery of North Rhine-Westphalia.
View entry
Prof. Christian Strassburg, Direktor der Klinik für Allgemeine Innere Medizin am UKB, mahnt: „Die Abnehmpille ist nicht einfach nur irgendein Spaßfaktor, um jetzt ein bisschen abzunehmen!“

Publication

Weight-Loss Pill Instead of Injection: Finally, an Easy Way to Lose Weight?

—As of September 1, semaglutide will be available in Germany for the treatment of overweight and obesity in tablet form for the first time. The therapy, previously known primarily as a “weight-loss injection,” can now also be taken orally. The market launch is likely to attract considerable interest – but anyone considering treatment should be aware of one thing first: the tablet is not a way to lose a few kilos, but a prescription medication for the treatment of a chronic disease.
View entry
Prof. Matthias Geyer, - together with Prof. Robert P. Fisher from New York, provides an overview of the current state of research on the transcriptional regulation of cyclin-dependent kinases (CDKs) and the prospects for cancer treatment.

Publication

A Ray of Hope in the Fight Against Cancer

—Cancer is the second leading cause of death in Germany. In the search for new therapeutic approaches that target the uncontrolled growth of tumor cells, a class of enzymes known as cyclin-dependent kinases (CDKs) has come into focus. This is because this family of enzymes plays a fundamental role in gene expression and cell division. An overview of the current state of research on the transcriptional regulation of CDKs and the prospects for cancer treatment was compiled by Prof. Matthias Geyer of the UKB in collaboration with Prof. Robert P. Fisher and has now been published.
View entry

Back to the news overview