Skip to main content
News Icon

Publication

Nature Publication by Heneka and colleagues

Inflammatory Processes Drive Progression of Alzheimer's and Other Brain Diseases

Report in "Nature" Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by Prof. Michael Heneka (DZNE), member of cluster of excellence ImmunoSensation, and the University of Bonn comes to this conclusion in the journal "Nature". The findings are based on the analyses of human brain tissue and further lab studies. In the particular case of Alzheimer's the results reveal a hitherto unknown connection between Abeta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies. ies. In the particular case of Alzheimer's the results reveal a hitherto unknown connection between Abeta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies.

Publication

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al., Nature (2019), DOI: 10.1038/s41586-019-1769-z

Related news

Smartphone-based retinal imaging in clinical practice in India: - The image was taken during a collaborative project between University Hospital Bonn (UKB) and Sankara Eye Foundation India on smartphone-based telemedical screening for diabetic retinopathy.

Publication

Smartphones as Retinal Cameras: New Opportunities for Global Eye Care

—Smartphones could play an important role in the early detection of eye diseases, including in settings where specialized ophthalmic infrastructure is limited. An international team of experts led by the UKB and the University of Bonn has comprehensively reviewed the current global landscape of smartphone-based fundus imaging. The researchers highlight the technical and clinical possibilities that already exist today, identify the limitations of these methods, and outline the conditions that must be met so that smartphone-based retinal imaging can be more widely integrated into screening.
View entry
Pseudocolored electron microscope image of a macrophage

Publication

Microplastics Cause Fatty Liver Disease in Mice

—Microplastics appear capable of significantly impairing the function of phagocytes in the liver, at least in mice. In turn, this disrupts the metabolism of this vital organ and increases the build-up of fat inside it. These are the key findings from a joint German-Austrian study led by the University of Bonn, details of which have now been published in the journal “Nature Metabolism.”
View entry
Pressefoto

Publication

Decoding the Effects of Obesity

—A group of innate immune cells known as group 2 innate lymphoid cells (ILC2s) are essential for maintaining a healthy metabolic balance in adipose tissue. Obesity significantly impairs the number and function of ILC2s. How ILC2s are disrupted by obesity has so far remained unclear. Researchers from the UKB and the University of Bonn have now shown in obese mice that acetyl-CoA carboxylase 1, a key enzyme in fatty acid biosynthesis, is a crucial regulator of the maintenance and function of ILC2 immune cells in adipose tissue. The results have now been published in the journal Cell Metabolism.
View entry

Back to the news overview