Skip to main content
News Schmidt-Burgk 07.2021
The development team behind the LAMP-Seq method (l-r): Dr. Dr. Ricarda Schmithausen (Institute of Hygiene and Public Health), Prof. Dr. Jonathan Schmid-Burgk (Institute of Clinical Chemistry and Clinical Pharmacology), Dr. Kerstin Ludwig (Institute of Human Genetics) and Dr. Per Hoffmann (Institute of Human Genetics)
© F. Heyder / UKB

Publication

New corona mass test developed by Cluster member

Cluster member Jonathan Schmid-Burgk and colleagues developed a new corona test that is up to 100 times more sensitive than rapid antigen tests.

The "LAMP-Seq" test is based on sequencing technology and can analyze a large number of swabs simultaneously with similar high sensitivity to the commonly used qPCR test. The innovative method offers great potential, especially for systematic testing in day care centers, schools or companies. The results of the study on the new Corona test have been published in the renowned journal "Nature Biotechnology". WDR Lokalzeit from Bonn also reported about this new Corona test and talked to the scientists involved.


Read more in the UKB press release (german)
or watch the TV report from the WDR Lokalzeit (german):

Publication

Kerstin U. Ludwig, Ricarda M. Schmithausen, David Li, Max L. Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikolaj Slabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S. Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M. Hochfeld, Eva C. Beins, Ines H. Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Jacob D. Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus M. Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L. Schmid-Burgk: "LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding", Nature Biotechnology,
https://www.nature.com/articles/s41587-021-00966-9

Related news

(from left) Julia Nicke and Dr. Mona Malek Mohammadi have identified a previously unknown signaling pathway in the immune system that helps newborn heart cells survive and regenerate after injury.

Publication

Central Hub for Heart Repair Discovered Bonn study: Heart muscle interaction enables cardiac regeneration in the neonatal heart

—Researchers at the University Hospital of Bonn (UKB) and the University of Bonn have identified a previously unknown signaling pathway in the immune system that helps newborn heart cells survive and regenerate after injury. The findings could open new avenues for future therapies aimed at repairing damaged adult hearts after heart attacks or chronic cardiovascular disease. The study has now been published in the journal Cell Communication and Signaling (Springer Nature).
View entry
News Icon

Publication

Malaria Causes Permanent Damage to Phagocytes in the Spleen

—Macrophages formed in the bone marrow can only assume the function of embryonal phagocytes, or “scavenger cells,” to a certain degree according to a study by the University of Bonn and the Peter Doherty Institute for Infection and Immunity at the University of Melbourne. The researchers have demonstrated that malaria infection causes permanent damage to resident CD163 macrophages in the spleen, which are responsible for cleaning the blood, recycling iron and communicating with other cells involved in the body’s immune response.
View entry
Tracking glioblastoma cell spread in human brain tissue

Publication

Core2Edge: How tumor cells conquer the brain

—Glioblastoma is an aggressive brain tumor that infiltrates deep into the surrounding brain tissue. Even after surgery, tumor cells remain in the brain and the tumor recurs. Bonn researchers have now developed Core2Edge, a model based entirely on human tissue that captures these hard-to-access infiltration zones at the tumor margin. The model enables investigation of the invasive front and direct assessment of new drug candidates in human tissue - without the need for animal testing. The study of the Brain Tumor Translational Research Group has now been published in Nature Protocols.
View entry

Back to the news overview