Skip to main content

News categories: Publication

New insights into our immune system

Bcl6 important for the formation of certain dendritic cells.

Dendritic cells play an important role in setting the course of our immune system. However, what determines their heterogeneity and functional specialization is still not sufficiently understood. An international collaboration consisting of researchers from the University Hospital Bonn (UKB), the University of Bonn and the Technical University of Denmark, among others, has investigated the role of the transcription factor Bcl6 in dendritic cells in a mouse model and discovered that a subgroup is highly dependent on this protein. The findings contribute to a better understanding of immunological processes during infections, vaccinations, allergies and autoimmunity. The results have now been published in the renowned scientific journal "Nature Communications".

Dendritic cells are part of our innate immune system and occupy a central position there. "These cells are particularly good at initiating an effective T-cell-mediated immune response of the acquired immune system," explains co-corresponding author Prof. Dirk Baumjohann from the Medical Clinic III for Hematology, Oncology, Immuno-Oncology and Rheumatology at the UKB, who is a member of the Cluster of Excellence ImmunoSensation2 and the Transdisciplinary Research Area (TRA) "Life & Health" at the University of Bonn. "However, it is still unclear what exactly drives their heterogeneity and functional specialization."

Previous studies have investigated the function of the protein Bcl6 in dendritic cells - in some cases with varying results. The aim of the current study is to harmonize the sometimes contradictory data using an in-depth analysis.

Bcl6 as an important transcription factor

The researchers therefore used a mouse model to investigate how the absence of Bcl6 affects all dendritic cell subgroups. "We found that in particular one specific dendritic cell subgroup (cDC2) is highly dependent on Bcl6," explains Prof. Katharina Lahl, who led the project at the Technical University of Denmark and is now continuing her work in Calgary. "Bcl6 deficiency leads to a lack of a dendritic cell subpopulation and results in impaired antibody responses in the spleen." As a result, the animals showed weakened immune responses in infection and vaccination models. "Bcl6 deficiency also led to the loss of the cDC2 subgroup in the large intestine, which caused a delayed recovery from an intestinal infection," adds Prof. Lahl.

In addition, the researchers were able to demonstrate with their study that the gene expression program in dendritic cells is already decisive for the subsequent cell fate of T cells and the associated immune response.

"The function of Bcl6 in dendritic cells overlaps with the already known function of Bcl6 in T cells and B cells and thus complements a gene expression program that acts synergistically across different immune cells," says Prof. Baumjohann. "These findings can contribute to the development of new therapeutic strategies, for example by strengthening specific dendritic cells during infection or vaccination or weakening them in allergies and autoimmune diseases."

Baumjohann Pulpa der Milz
Image of a murine white pulp of the spleen, - in which large amounts of B cells (B220, blue) and dendritic cells (CD11c, green) can be found. The red pulp is highlighted by myeloid cell staining (SIRPa, red).
© Technische Universität Dänemark (DTU)/Urs Michael Mörbe


Hongkui Xiao, et al (2024)

Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses

Nature Communications, DOI:


Prof. Dirk Baumjohann

Medical Clinic III for Haematology, Oncology, Immuno-oncology and Rheumatology

University Hospital Bonn

Cluster of Excellence ImmunoSensation2 & TRA "Life & Health", University of Bonn


Press release of the University of Bonn


Johannes Seiler

Science editor

University of Bonn


Related news

20240523 PM  Hoelzel Herrlinger Layer 1212 wp header

News categories: Publication

Novel RNA therapy is effective against highly aggressive brain tumors

The findings of the GLORIA study were published in "Nature Communications"
View entry
20240506 PM Hoerauf Achim 2048x854px

News categories: Publication

New antibiotic against river blindness and lymphatic filariasis pathogens

Japanese fund supports research into the treatment of filarial infections at University Hospital Bonn.
View entry
20240321 PM PM Klumper 010

News categories: Publication

Bonn scientists predict the connection between biomarker expression and long-term survival in patients with urothelial cancer

PD Dr. Niklas Klümper and Prof. Michael Hölzel discovered that NECTIN4 amplifications are genomic predictors of long-term survival in patients suffering from metastatic urothelial cancer (mUC). Their findings were published in the latest edition of the “Journal of Clinical Oncology”.
View entry

Back to the news overview