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News Ulas 10.2019
During tumor development, macrophages (brown), the scavengers of the immune system, migrate into the diseased tissue (cancer cells: blue) without destroying it.
© Karin E. de Visser / the Netherlands Cancer Institute

Publication

New method identifies aggressive breast cancer

Aggressive forms of breast cancer often manipulate the immune response in their favor. This manipulation is revealed in humans by the same immunological "signature" as in mice. This is shown by a study carried out by scientists from the University of Bonn and memebers of the Cluster of Excellence ImmunoSensation together with Dutch colleagues. Their method makes it possible to obtain an indication of the prognosis of the disease using patients' tumor tissue. The results are published in the journal "Cell Reports".


Publication

Sander Tuit, Camilla Salvagno, Theodore S. Kapellos, Cheei-Sing Hau, Lea Seep, Marie Oestreich, Kathrin Klee, Karin E. de Visser, Thomas Ulas und Joachim L. Schultze: Transcriptional signature derived from murine tumor-associated macrophages correlates with poor outcome in breast cancer patients. Cell Reports; DOI: 10.1016/j.celrep.2019.09.067

Contact

Dr. Thomas Ulas

Head of the Bioinformatics Working Group

LIMES-Institute

University of Bonn

Tel. +49-228-7362722

E-mail: t.ulas@uni-bonn.de

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Publication

B cells maintain antigen presentation in the splenic marginal zone

—A team of international researchers, including ImmunoSensation³ members Prof. Niels Lemmermann and Prof. Andreas Schlitzer, shows that B cells support antiviral CD8⁺ T-cell responses beyond antibody production. In a murine CMV model, B-cell deficiency weakened virus-specific CD8⁺ T-cell responses. Mechanistically, B-cell-derived lymphotoxin β maintained CD169⁺ macrophages and Langerin⁺ cDC1 cells in the splenic marginal zone, enabling efficient T-cell priming. The study was published in Cellular & Molecular Immunology.
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