Skip to main content
News Icon

Publication

NLRP3 inflammasome activation drives tau protein

Inflammatory Processes Drive Progression of Alzheimer's and Other Brain Diseases.

Report in "Nature" Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by Prof. Michael Heneka (DZNE), member of cluster of excellence ImmunoSensation, and the University of Bonn comes to this conclusion in the journal "Nature". The findings are based on the analyses of human brain tissue and further lab studies. In the particular case of Alzheimer's the results reveal a hitherto unknown connection between Abeta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies. ies. In the particular case of Alzheimer's the results reveal a hitherto unknown connection between Abeta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies.

Publication

NLRP3 inflammasome activation drives tau pathology

Christina Ising et al., Nature (2019), DOI: 10.1038/s41586-019-1769-z

Related news

News Ludwig

Publication

New findings on infection with the Epstein-Barr virus

—The Epstein-Barr virus (EBV) can cause certain types of cancer or autoimmune diseases, but how the body controls this common viral infection is largely unknown. Bonn researchers have now identified genetic and non-genetic factors that help the body fight EBV. To do this, they evaluated genome sequencing data, which is actually intended for characterizing the human genome, in a new way. Using the new technique, they were able to estimate the amount of EBV in the blood and find correlations in large health data sets. Their findings have now been published in the renowned journal Nature.
View entry
News Icon

Publication

New insights into the human immune defense against poxviruses

—An international research team involving Bonn scientist has made an important contribution to understanding the human immune response to poxviruses: The scientists were able to show for the first time that different human cell types recognize poxviruses via different sensors in order to trigger inflammatory responses. At the same time, the team developed the world's first nanobodies that can specifically block the DNA sensor AIM2 – a tool that opens up new possibilities for inflammation and infection research. The paper has now been published in The EMBO Journal.
View entry
News Icon

Publication

Multiple Sclerosis: Potential biomarker linked to progression and brain inflammation identified

—Better ways to detect ongoing brain damage in multiple sclerosis (MS) are urgently needed. An international team of scientists, including ImmunoSensation³ member Prof. Anne-Katrin Pröbstel, has identified a molecular circuit that drives brain injury in MS. In a mouse model, blocking the enzyme Bruton's tyrosine kinase prevented harmful clustering of immune cell and brain tissue demage. Patient data revealed the same immune signaling pattern, suggesting strong translational potential for diagnosis. The study was recently published in Nature Immunology.
Full publication

Back to the news overview