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NLRP3 inflammasome activation drives tau protein

Inflammatory Processes Drive Progression of Alzheimer's and Other Brain Diseases.

Report in "Nature" Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by Prof. Michael Heneka (DZNE), member of cluster of excellence ImmunoSensation, and the University of Bonn comes to this conclusion in the journal "Nature". The findings are based on the analyses of human brain tissue and further lab studies. In the particular case of Alzheimer's the results reveal a hitherto unknown connection between Abeta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies. ies. In the particular case of Alzheimer's the results reveal a hitherto unknown connection between Abeta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies.

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NLRP3 inflammasome activation drives tau pathology

Christina Ising et al., Nature (2019), DOI: 10.1038/s41586-019-1769-z

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