Skip to main content
Graphical abstract for Tsukamoto et al., Targeting cap1 RNA methyltransferases as an antiviral strategy, Cell Chemical Biology (2023)

News categories: Publication

Review on new antiviral strategy now online

The review publication of Yuta Tsukamoto et al. is now available in the current issue of Cell Chemical Biology. Based on his latest Science paper, Yuta Tsukamoto now highlights the importance and potential of “Targeting cap1 RNA methyltransferases as an antiviral strategy”. He and his co-authors outline the game-changing options in the treatment of viral infections.


Publication

Tsukamoto Y, Igarashi M, Kato H.
Targeting cap1 RNA methyltransferases as an antiviral strategy.
Cell Chem Biol. 2023 Dec 5:S2451-9456(23)00426-9.
doi: 10.1016/j.chembiol.2023.11.011.
Epub ahead of print. PMID: 38091983.

Related news

Die künstlerische Abbildung zeigt Seeigel der Art Arbacia punctulata, die Spermien (weiße Wolke) und Eier (orangefarbene Wolke) ins Wasser abgeben. Von den Eiern freigesetzte Pheromone steuern die Synchronität des Laichens.

News categories: Publication

What Makes Sea Urchin and Salmon Sperm Swim

A recent study by the Max Planck Institute for Multidisciplinary Sciences and the University of Bonn shows that pH plays a crucial role in sperm motility in sea urchins and salmon. A rise in pH activates the enzyme soluble adenylyl cyclase (sAC), which produces the messenger molecule cAMP and thereby regulates sperm movement. This mechanism may be widespread in many marine invertebrates and fish. The findings have now been published in the Journal Proceedings of the National Academy of Sciences.
View entry
3 Wissenschaftler

News categories: Publication

Immune cells remember their location

A new AI-based method reconstructs spatial information about where immune cells were originally located in an organ, even after these cells have been removed from the tissue and analyzed individually. To accomplish this, Researchers at the University Hospital Bonn (UKB) and the University of Bonn use the transcriptome, i.e., the entirety of all messenger RNA transcripts produced by genes within a cell at a given time. The work has now been published in the journal Advanced Science and introduces the new MERLIN algorithm.
View entry
News Icon

News categories: Publication

B cells maintain antigen presentation in the splenic marginal zone

A team of international researchers, including ImmunoSensation³ members Prof. Niels Lemmermann and Prof. Andreas Schlitzer, shows that B cells support antiviral CD8⁺ T-cell responses beyond antibody production. In a murine CMV model, B-cell deficiency weakened virus-specific CD8⁺ T-cell responses. Mechanistically, B-cell-derived lymphotoxin β maintained CD169⁺ macrophages and Langerin⁺ cDC1 cells in the splenic marginal zone, enabling efficient T-cell priming. The study was published in Cellular & Molecular Immunology.
Full publication

Back to the news overview