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Study for treatment of lymphatic filariosis in Science Translational Medicine published

Neglected tropical diseases such as Lymphatic filariosis are common in tropical and subtropical areas. Here mostly poor people are affected.
An international consortium with a contribution of scientists from the Cluster of Excellence ImmunoSensation identified a new substance ABBV-4083 in the fight against adult worms, the cause of lymphatic filariosis.
Dr. Marc Hübner and Prof. Hörauf are working in the Institute of Medical Microbiology, Immunology and Parasitology at the University Hospital Bonn.


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Mark J. Taylor, Thomas W. von Geldern, Louise Ford, Marc P. Hübner, Kennan Marsh, Kelly L. Johnston, Hanna T. Sjoberg, Sabine Specht, Nicolas Pionnier, Hayley E. Tyrer, Rachel H. Clare, Darren A. N. Cook, Emma Murphy, Andrew Steven, John Archer, Dominique Bloemker, Franziska Lenz, Marianne Koschel, Alexandra Ehrens, Haelly M. Metuge, Valerinne C. Chunda, Patrick W. Ndongmo Chounna, Abdel J. Njouendou, Fanny F. Fombad, Robert Carr, Howard E. Morton, Ghaith Aljayyoussi, Achim Hoerauf, Samuel Wanji, Dale J. Kempf, Joseph D. Turner, Stephen A. Ward: Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis, Science Translational Medicine, DOI: 10.1126/scitranslmed.aau2086

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Image 1: Malaria is not transmitted directly from person to person. Infection requires the bite of a female Anopheles mosquito carrying the malaria parasite. Image 2: Prof. Dr. Achim Hörauf, Director of the Institute of Medical Microbiology, Immunology and Parasitology at Bonn University Hospital (UKB), is an established expert in tropical diseases, among other fields.

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As Temperatures Fall, So Does the Risk of Malaria Transmission

—The good news comes with autumn: As temperatures fall, the risk of further malaria transmission in Germany also decreases significantly. However, the current cases reported in the vicinity of Frankfurt Airport show that, in very rare cases, malaria can occur in Germany even without previous travel abroad. In such cases, early diagnosis is crucial.
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New Findings on Information Processing in the Brain: - Examples of Dendritic Shaft Constrictions (DSCs) imaged used high resolution microscopy techniques, expansion microscopy (left), STED (middle) and electron microscopy (right). Arrowheads indicate the position of DSCs.

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New Findings on Information Processing in the Brain

—Neurons receive thousands of signals via tree-like extensions called dendrites. Until now, these dendrites were thought to be relatively smooth cables that conduct electrical signals to the cell body. Using various advanced microscopy techniques, an international research team has identified tiny, previously overlooked constrictions along the dendrites. The study results have now been published in the journal Science Advances.
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Diets need more sustainability

—There has been a rapid increase in cardiovascular and metabolic conditions in sub-Saharan Africa. What is the link between sustainable diets that are nutritious, environmentally friendly, economically affordable, and socioculturally acceptable, and cardiometabolic conditions? An international research team led by Prof. Dr. Ina Danquah, Hertz Chair for Innovation for Planetary Health and Director at Center for Development Research (ZEF) at University of Bonn, investigated this question among Ghanaian adults who live in various locations.
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