Jun.-Prof. Dr. Kathrin Leppek
Institute of Clinical Chemistry and Clinical Pharmacology
kleppek@uni-bonn.de View member: Jun.-Prof. Dr. Kathrin Leppek
Developmental cell
Metabolic enzymes can moonlight as gene regulators by binding RNA, but the functions of most enzyme-RNA interactions remain unclear. In this issue of Developmental Cell, Zhang et al. reveal that the proline biosynthesis enzyme Δ1-pyrroline-5-carboxylate synthase (P5CS) inhibits oncogene translation by blocking the assembly of the pre-initiation complex.
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PMID: 42419282