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Dr. Anna Aschenbrenner


Institute of Systems Medicine, DZNE and LIMES Institute

DZNE Venusberg-Campus 1 53127 Bonn

+49 228 43302690

Using systems immunology approaches, I am interested in understanding immune cells in health and disease, in particular by bringing single-cell omics technologies to large cohort studies in infectious diseases including COVID-19, sepsis, and HIV. We recently showed for COVID-19 how bulk blood transcriptomics can be used to determine molecular signatures of the disease and facilitate drug repurposing. Further, we have developed an approach for the analysis of multi-layered data from large human cohorts utilizing human variance as a surrogate to analyse functional traits and are applying this in the context of aging and immune system homeostasis.

Recent publications

  • Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome - State of the art: Report of the 2nd international meeting at the Charité fatigue center.

    Autoimmunity reviews

    Authors: Sophie Steiner, Annick Fehrer, Friederike Hoheisel, Simon Schoening, Anna Aschenbrenner, Nina Babel, Judith Bellmann-Strobl, Carsten Finke, Øystein Fluge, Laura Froehlich, Andreas Goebel, Bettina Grande, Johannes-Peter Haas, Bettina Hohberger, Leonard A Jason, Anthony L Komaroff, Eliana Lacerda, Max Liebl, Andrea Maier, Olav Mella, Luis Nacul, Friedemann Paul, Bhupesh K Prusty, Christian Puta, Gabriela Riemekasten, Wolfgang Ries, Peter C Rowe, Birgit Sawitzki, Yehuda Shoenfeld, Joachim L Schultze, Martina Seifert, Nuno Sepúlveda, Franziska Sotzny, Elisa Stein, Michael Stingl, Friederike Ufer, Christian Veauthier, Francisco Westermeier, Klaus Wirth, Bernd Wolfarth, Pawel Zalewski, Uta Behrends, Carmen Scheibenbogen

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  • Chromatin accessibility profiling of targeted cell populations with laser capture microdissection coupled to ATAC-seq.

    Cell reports methods

    Authors: Caterina Carraro, Lorenzo Bonaguro, Rachana Srinivasa, Martina van Uelft, Victoria Isakzai, Jonas Schulte-Schrepping, Prerna Gambhir, Tarek Elmzzahi, Jessica V Montgomery, Hannah Hayer, Yuanfang Li, Heidi Theis, Michael Kraut, Krishnaa T Mahbubani, Anna C Aschenbrenner, Ireen König, Eugenio Fava, Hans-Ulrich Fried, Elena De Domenico, Marc Beyer, Adem Saglam, Joachim L Schultze

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  • Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19.

    Respiratory research

    Authors: Emma J Kooistra, Kilian Dahm, Antonius E van Herwaarden, Jelle Gerretsen, Melanie Nuesch Germano, Karoline Mauer, Ruben L Smeets, Sjef van der Velde, Maarten J W van den Berg, Johannes G van der Hoeven, Anna C Aschenbrenner, Joachim L Schultze, Thomas Ulas, Matthijs Kox, Peter Pickkers

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