Institute of Systems Medicine, DZNE and LIMES Institute
DZNE Venusberg-Campus 1 53127 Bonn
Using systems immunology approaches, I am interested in understanding immune cells in health and disease, in particular by bringing single-cell omics technologies to large cohort studies in infectious diseases including COVID-19, sepsis, and HIV. We recently showed for COVID-19 how bulk blood transcriptomics can be used to determine molecular signatures of the disease and facilitate drug repurposing. Further, we have developed an approach for the analysis of multi-layered data from large human cohorts utilizing human variance as a surrogate to analyse functional traits and are applying this in the context of aging and immune system homeostasis.
