The pathophysiology of sepsis and precision-medicine-based immunotherapy.
Nature immunology
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DZNE Venusberg-Campus 1 53127 Bonn
Using systems immunology approaches, I am interested in understanding immune cells in health and disease, in particular by bringing single-cell omics technologies to large cohort studies in infectious diseases including COVID-19, sepsis, and HIV. We recently showed for COVID-19 how bulk blood transcriptomics can be used to determine molecular signatures of the disease and facilitate drug repurposing. Further, we have developed an approach for the analysis of multi-layered data from large human cohorts utilizing human variance as a surrogate to analyse functional traits and are applying this in the context of aging and immune system homeostasis.
Nature immunology
View this publicationEuropean journal of immunology
View this publicationFrontiers in immunology
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