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Dr. Anna Aschenbrenner


Institute of Systems Medicine, DZNE and LIMES Institute

DZNE Venusberg-Campus 1 53127 Bonn

+49 228 43302690

Using systems immunology approaches, I am interested in understanding immune cells in health and disease, in particular by bringing single-cell omics technologies to large cohort studies in infectious diseases including COVID-19, sepsis, and HIV. We recently showed for COVID-19 how bulk blood transcriptomics can be used to determine molecular signatures of the disease and facilitate drug repurposing. Further, we have developed an approach for the analysis of multi-layered data from large human cohorts utilizing human variance as a surrogate to analyse functional traits and are applying this in the context of aging and immune system homeostasis.

Recent publications

  • The pathophysiology of sepsis and precision-medicine-based immunotherapy.

    Nature immunology

    Authors: Evangelos J Giamarellos-Bourboulis, Anna C Aschenbrenner, Michael Bauer, Christoph Bock, Thierry Calandra, Irit Gat-Viks, Evdoxia Kyriazopoulou, Mihaela Lupse, Guillaume Monneret, Peter Pickkers, Joachim L Schultze, Tom van der Poll, Frank L van de Veerdonk, Alexander P J Vlaar, Sebastian Weis, W Joost Wiersinga, Mihai G Netea

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  • Whole blood stimulation as a tool for studying the human immune system.

    European journal of immunology

    Authors: Sophie Müller, Charlotte Kröger, Joachim L Schultze, Anna C Aschenbrenner

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  • Identification of drug candidates targeting monocyte reprogramming in people living with HIV.

    Frontiers in immunology

    Authors: Rainer Knoll, Lorenzo Bonaguro, Jéssica C Dos Santos, Stefanie Warnat-Herresthal, Maartje C P Jacobs-Cleophas, Edda Blümel, Nico Reusch, Arik Horne, Miriam Herbert, Melanie Nuesch-Germano, Twan Otten, Wouter A van der Heijden, Lisa van de Wijer, Alex K Shalek, Kristian Händler, Matthias Becker, Marc D Beyer, Mihai G Netea, Leo A B Joosten, Andre J A M van der Ven, Joachim L Schultze, Anna C Aschenbrenner

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