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Dr. Lorenzo Bonaguro

Member

Center for Neurodegenerative Diseases (DZNE)

Raum No. B.3.031-050 (DZNE), Venusberg-Campus 1, 53127 Bonn

lorenzobonaguro@uni-bonn.de

+49 228 43302691

Our research group in molecular and translational immunomics uses a systems-level omics approach to understand how the immune system functions in health and disease. We integrate classical hypothesis-driven research with high-resolution, high-throughput technologies, such as single-cell RNA sequencing, and advanced analytical methods, including artificial intelligence approaches.
Specifically, we are interested in how environmental exposures like diet and pollution affect the immune system's ability to respond to challenges. We investigate the exposome's influence on immune response and vaccination efficacy using model systems like tonsil organoids and computational tools to decipher the molecular mechanisms that govern immune fitness.

Dr. Bonaguro

Recent publications

  • BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue.

    The EMBO journal

    Authors: Katharina Sieckmann, Nora Winnerling, Dalila Juliana Silva Ribeiro, Seniz Yüksel, Ronja Kardinal, Lisa Maria Steinheuer, Fabian Frechen, Luis Henrique Corrêa, Geza Schermann, Christina Klausen, Nelli Blank-Stein, Jonas Schulte-Schrepping, Collins Osei-Sarpong, Matthias Becker, Lorenzo Bonaguro, Marc Beyer, Helen Louise May-Simera, Jelena Zurkovic, Christoph Thiele, Kevin Thurley, Lydia Sorokin, Carmen Ruiz de Almodovar, Elvira Mass, Dagmar Wachten

  • Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial.

    Nature medicine

    Authors: Godfrey S Temba, Tal Pecht, Vesla I Kullaya, Nadira Vadaq, Mary V Mosha, Thomas Ulas, Sneha Kanungo, Liesbeth van Emst, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Elias Mafuru, Paolo Lionetti, Musa M Mhlanga, Andre J van der Ven, Duccio Cavalieri, Leo A B Joosten, Reginald A Kavishe, Blandina T Mmbaga, Joachim L Schultze, Mihai G Netea, Quirijn de Mast

  • Unveiling the power of high-dimensional cytometry data with cyCONDOR.

    Nature communications

    Authors: Charlotte Kröger, Sophie Müller, Jacqueline Leidner, Theresa Kröber, Stefanie Warnat-Herresthal, Jannis Bastian Spintge, Timo Zajac, Anna Neubauer, Aleksej Frolov, Caterina Carraro, Frank Jessen, Simone Puccio, Anna C Aschenbrenner, Joachim L Schultze, Tal Pecht, Marc D Beyer, Lorenzo Bonaguro

All publications by Dr. Lorenzo Bonaguro