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featured publications

  • ConvexGating infers gating strategies from clusters in single cell cytometry data.

    Nature communications

    Authors: Vincent D Friedrich, Karola Mai, Thomas P Hofer, Elfriede Nößner, Lorenzo Bonaguro, Celia L Hartmann, Aleksej Frolov, Caterina Carraro, Doaa Hamada, Mehrnoush Hadaddzadeh Shakiba, Heidi Theis, Dalila Juliana Silva Ribeiro, Dagmar Wachten, F Thomas Wunderlich, Markus Scholz, Fabian J Theis, Matthias Becker, Marc D Beyer, Joachim L Schultze, Maren Büttner

  • Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

    Nature neuroscience

    Authors: Xin Yan, Christina Georgopoulou, Hang-Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao, Shobhit Agrawal, Sophie Crux, Andrew W Daman, Lena Wischhof, Miriam Stork, Margit Zweyer, Emma Dorotea Zanfi, Manon Chevallot-Beroux, Yunxiao Li, Elena De-Domenico, Dina Hüsson, Lorenzo Bonaguro, Yuanfang Li, Jonas Schulte-Schrepping, Qingyi Liang, Ketty Kessler, Dan Ehninger, Shahin Rafii, Jiankai Luo, Andreas Hermann, Annett Halle, Ying Liu, Elvira Mass, Melania Capasso, Hiroki Kato, Joachim L Schultze, Pierluigi Nicotera, Daniele Bano, Steven Zvi Josefowicz, Martin Fuhrmann, Thomas Ulas, Marc Beyer, Juntang Lin, Monique M B Breteler, N Ahmad Aziz, Paolo Salomoni

  • Molecular architecture of human dermal sleeping nociceptors.

    Cell

    Authors: Jannis Körner, Derek Howard, Hans Jürgen Solinski, Marisol Mancilla Moreno, Natja Haag, Andrea Fiebig, Anna Maxion, Shamsuddin A Bhuiyan, Idil Toklucu, Raya A Bott, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Stephanie Shiers, Nikhil N Inturi, Esther Eberhardt, Lisa Ernst, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Marc D Beyer, Thomas Stiehl, William Renthal, Ingo Kurth, Jenny Tigerholm, Jordi Serra, Theodore J Price, Martin Schmelz, Barbara Namer, Shreejoy Tripathy, Angelika Lampert

  • Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.

    Development (Cambridge, England)

    Authors: Nikola Makdissi, Daria Hirschmann, Aleksej Frolov, Inaam Sado, Bastian Bennühr, Fabian Nikolka, Jingyuan Cheng, Nelli Blank-Stein, Maria Francesca Viola, Mohamed Yaghmour, Philipp Arnold, Lorenzo Bonaguro, Matthias Becker, Christoph Thiele, Felix Meissner, Karsten Hiller, Marc D Beyer, Elvira Mass

  • BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue.

    The EMBO journal

    Authors: Katharina Sieckmann, Nora Winnerling, Dalila Juliana Silva Ribeiro, Seniz Yüksel, Ronja Kardinal, Lisa Maria Steinheuer, Fabian Frechen, Luis Henrique Corrêa, Geza Schermann, Christina Klausen, Nelli Blank-Stein, Jonas Schulte-Schrepping, Collins Osei-Sarpong, Matthias Becker, Lorenzo Bonaguro, Marc Beyer, Helen Louise May-Simera, Jelena Zurkovic, Christoph Thiele, Kevin Thurley, Lydia Sorokin, Carmen Ruiz de Almodovar, Elvira Mass, Dagmar Wachten

  • Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial.

    Nature medicine

    Authors: Godfrey S Temba, Tal Pecht, Vesla I Kullaya, Nadira Vadaq, Mary V Mosha, Thomas Ulas, Sneha Kanungo, Liesbeth van Emst, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Elias Mafuru, Paolo Lionetti, Musa M Mhlanga, Andre J van der Ven, Duccio Cavalieri, Leo A B Joosten, Reginald A Kavishe, Blandina T Mmbaga, Joachim L Schultze, Mihai G Netea, Quirijn de Mast

  • Unveiling the power of high-dimensional cytometry data with cyCONDOR.

    Nature communications

    Authors: Charlotte Kröger, Sophie Müller, Jacqueline Leidner, Theresa Kröber, Stefanie Warnat-Herresthal, Jannis Bastian Spintge, Timo Zajac, Anna Neubauer, Aleksej Frolov, Caterina Carraro, Frank Jessen, Simone Puccio, Anna C Aschenbrenner, Joachim L Schultze, Tal Pecht, Marc D Beyer, Lorenzo Bonaguro

  • Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli.

    Scientific reports

    Authors: Lena Wischhof, Amal John Mathew, Lorenzo Bonaguro, Marc Beyer, Dan Ehninger, Pierluigi Nicotera, Daniele Bano

  • Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiation.

    Cell reports. Medicine

    Authors: Tobias Grass, Zeynep Dokuzluoglu, Felix Buchner, Ines Rosignol, Joshua Thomas, Antonio Caldarelli, Anna Dalinskaya, Jutta Becker, Fabian Rost, Michele Marass, Brunhilde Wirth, Marc Beyer, Lorenzo Bonaguro, Natalia Rodriguez-Muela

  • Top publication

    The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation.

    Cell

    Authors: Rainer Knoll, Elisa T Helbig, Kilian Dahm, Olufemi Bolaji, Frederik Hamm, Oliver Dietrich, Martina van Uelft, Sophie Müller, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Lev Petrov, Benjamin Krämer, Michael Kraut, Paula Stubbemann, Charlotte Thibeault, Sophia Brumhard, Heidi Theis, Gudrun Hack, Elena De Domenico, Jacob Nattermann, Matthias Becker, Marc D Beyer, David Hillus, Philipp Georg, Constantin Loers, Janina Tiedemann, Pinkus Tober-Lau, Lena Lippert, Belén Millet Pascual-Leone, Frank Tacke, Gernot Rohde, Norbert Suttorp, Martin Witzenrath, Antoine-Emmanuel Saliba, Thomas Ulas, Julia K Polansky, Birgit Sawitzki, Leif E Sander, Joachim L Schultze, Anna C Aschenbrenner, Florian Kurth