PD Dr. med. Niklas Klümper, an advanced clinician-scientist in the ACCENT program at the University Hospital Bonn, focuses on uro-oncology and aims to improve treatment response predictions for targeted therapies, leading to more personalized approaches for uro-oncological diseases. His team has pioneered the prediction of immune checkpoint blockade responses through the analysis of longitudinal inflammatory markers, contributing to the field of immuno-oncology. They are also investigating the mechanisms of resistance to antibody-drug conjugates in patients with metastatic urothelial carcinoma, an emerging area of oncological therapies, and aim to improve precision oncology by tailoring treatment to the molecular profile of patients.
Recent publications
Integrating NECTIN4 Amplification With Membranous Nectin-4 Expression to Develop a Scoring System for Predicting Enfortumab Vedotin Response in Urothelial Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Authors:
Niklas Klümper, Thomas Büttner, Sebastian Rauch, Stefanie Zschäbitz, Florian Roghmann, Christian Bolenz, Fabienne Lange, Patricia Rausch, Friedemann Zengerling, Nadine Gaisa, Oliver Hahn, Constantin Schwab, Anna Scherping, Marieta Toma, Hendrik Heers, Phillipp Ivanyi, Guenter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Pia Paffenholz, Richard Weiten, Susanne Füssel, Christian Thomas, Marcus Sondermann, Ulrich Sommer, Kerstin Junker, Katrin Schlack, Jozefina Casuscelli, Can Aydogdu, Dora Niedersüß-Beke, Steffen Rausch, Christoph Kuppe, Joshua Meeks, Bonnie Choy, Sarmad Sadeghi, Parkash Gill, Manuel Ritter, Johannes Brägelmann, Michael Hölzel, Arndt Hartmann, Viktor Grünwald, Jonas Saal, Markus Eckstein
FGFR3 Testing in Urothelial Carcinoma: An Expert Commentary on Best Practices From Patient Identification to Result Reporting.
European urology oncology
Authors:
Eva M Compérat, Arndt Hartmann, Yves Allory, Beatriz Bellosillo, Rui Pedro Caetano Moreira Oliveira, Caterina Chiappetta, Farah Hodeib, Michael Hubank, Niklas Klümper, Yohann Loriot, Frédérique Penault-Llorca, Astrid Rijken, Ernst-Jan M Speel, Bernadett Szabados, Isabelle Vanden Bempt, Geert J L H Van Leenders, Mariavittoria Vescovo, Markus Eckstein