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PD Dr. Beate Kümmerer

Member

Institute of Virology

Venusberg-Campus 1, 53127 Bonn

Beate.Kuemmerer@uni-bonn.de

+49 228 28714468

The research of our group is focused on viruses that are transmitted to humans by an insect vector (arthropod-borne viruses). We mainly work on orthoflaviviruses and alphaviruses. Using reverse genetic systems as major tools, we elucidate special functions of viral proteins in the viral life cycle. In addition, we perform antiviral compound testing against different arboviruses and are involved in vaccine studies focusing on the analyses of the adaptive immune response.
The group also deals with host cell antiviral proteins and examines virus-host interactions with the emphasis to analyze the interplay of the virus with the innate immune system, and to define determinants important for host range restriction. Analyses are performed both in vertebrate and insect cell systems as well as in living mosquitoes. For mosquitoes, we are especially interested to elucidate mechanisms involved in sensing of foreign RNA resulting in activation of the mosquito immune system.

PD Dr. Beate Kümmerer

Recent publications

  • A multiregional serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae.

    PLoS neglected tropical diseases

    Authors: Jackson Emanuel, Jan Papies, Leonie Meiners, Talitha Veith, Victor M Corman, Tabea Binger, Erik Lattwein, Beate M Kümmerer, Susanne Zweerink, Kai Fechner, Florian Gloza-Rausch, Veronika Cottontail, Gaël D Maganga, Jonas Schmidt-Chanasit, Peter Vallo, Samuel K Oppong, Marco Tschapka, Chantal B E M Reusken, Rainer G Ulrich, Eric M Leroy, Jan Felix Drexler, Terry C Jones, Christian Drosten, Marcel A Müller

  • Structural and immunogenic characterisation of ChAdOx1 Chik-derived Chikungunya VLPs supports a mechanistic rationale for vaccine-induced protection.

    Npj viruses

    Authors: Young Chan Kim, Xiyong Song, Yasunori Watanabe, Raquel de Oliveira Souza, Robert Stass, Sthefany Pagliari, Max Crispin, Beate Mareike Kümmerer, Carla Claser, Thomas A Bowden, Juha T Huiskonen, Arturo Reyes-Sandoval

  • Maturation-deficient chikungunya virus elicits protective immune responses in a murine challenge model.

    NPJ vaccines

    Authors: Danillo Lucas Alves Esposito, Jhefferson Barbosa Guimarães, Benedito Antonio Lopes da Fonseca, Beate Mareike Kümmerer

All publications by PD Dr. Beate Kümmerer