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PD Dr. Gregor Hagelüken

Institute of Structural Biology

University Bonn, Institute of Structural Biology, Sigmund-Freud-Str. 25, D-53127 Bonn

+49 228 28751200


The research in my group focuses on two related topics. The first topic is bacterial immunity. The discovery of CRISPR defense systems has shown that bacteria have very complicated immune systems that protect the microorganisms from attack by phages, i.e. viruses that are specialized to infect bacteria. In addition to CRISPR, there are many other bacterial defense systems, many of which are strikingly similar to parts of the human immune system.
The second theme is the interface between pathogens and our immune system, such as the tricks that pathogens use to evade the latter. One example is a process by which pathogens such as Haemophilus influenzae scavenge a sugar molecule called sialic acid from our tissues and incorporate it into their cell wall to hide from our immune system.
Using general biochemistry and structural biology, we are trying to understand these systems and learn about the origin and function of our immune system.

Recent publications

  • Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.

    Nature communications

    Authors: Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D J Schiffelers, Florian I Schmidt, Matthias Geyer

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  • Publication categories: Top publication

    A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.

    Nucleic acids research

    Authors: Ann Kristin de Regt, Kanchan Anand, Katrin Ciupka, Felix Bender, Karl Gatterdam, Bastian Putschli, David Fusshöller, Daniel Hilbig, Alexander Kirchhoff, Charlotte Hunkler, Steven Wolter, Agathe Grünewald, Christina Wallerath, Christine Schuberth-Wagner, Janos Ludwig, Katrin Paeschke, Eva Bartok, Gregor Hagelueken, Gunther Hartmann, Thomas Zillinger, Matthias Geyer, Martin Schlee

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  • Adenylation Domain-Guided Recruitment of Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis.

    ACS chemical biology

    Authors: Daniel A Wirtz, Niels Schneberger, Sophie Klöppel, René Richarz, Matthias Geyer, Gabriele M König, Gregor Hagelueken, Max Crüsemann

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