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PD Dr. Gregor Hagelüken

Member

Institute of Structural Biology

University Bonn, Institute of Structural Biology, Sigmund-Freud-Str. 25, D-53127 Bonn

hagelueken@uni-bonn.de

+49 228 28751200

Website

The research in my group focuses on two related topics. The first topic is bacterial immunity. The discovery of CRISPR defense systems has shown that bacteria have very complicated immune systems that protect the microorganisms from attack by phages, i.e. viruses that are specialized to infect bacteria. In addition to CRISPR, there are many other bacterial defense systems, many of which are strikingly similar to parts of the human immune system.
The second theme is the interface between pathogens and our immune system, such as the tricks that pathogens use to evade the latter. One example is a process by which pathogens such as Haemophilus influenzae scavenge a sugar molecule called sialic acid from our tissues and incorporate it into their cell wall to hide from our immune system.
Using general biochemistry and structural biology, we are trying to understand these systems and learn about the origin and function of our immune system.

Gregor Hagelüken

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Recent publications

  • Pulse EPR Methods in the Angstrom to Nanometre Scale Shed Light on the Conformational Flexibility of a Fluoride Riboswitch.

    Angewandte Chemie (International ed. in English)

    Authors: Laura Remmel, Andreas Meyer, Katrin Ackermann, Gregor Hagelueken, Marina Bennati, Bela E Bode

  • The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease.

    Nucleic acids research

    Authors: Sophie C Binder, Niels Schneberger, Maximilian Schmitz, Marianne Engeser, Matthias Geyer, Christophe Rouillon, Gregor Hagelueken

  • Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies.

    NPJ genomic medicine

    Authors: Jil D Stegmann, Jeshurun C Kalanithy, Gabriel C Dworschak, Nina Ishorst, Enrico Mingardo, Filipa M Lopes, Yee Mang Ho, Phillip Grote, Tobias T Lindenberg, Öznur Yilmaz, Khadija Channab, Steve Seltzsam, Shirlee Shril, Friedhelm Hildebrandt, Felix Boschann, André Heinen, Angad Jolly, Katherine Myers, Kim McBride, Mir Reza Bekheirnia, Nasim Bekheirnia, Marcello Scala, Manuela Morleo, Vincenzo Nigro, Annalaura Torella, Michele Pinelli, Valeria Capra, Andrea Accogli, Silvia Maitz, Alice Spano, Rory J Olson, Eric W Klee, Brendan C Lanpher, Se Song Jang, Jong-Hee Chae, Philipp Steinbauer, Dietmar Rieder, Andreas R Janecke, Julia Vodopiutz, Ida Vogel, Jenny Blechingberg, Jennifer L Cohen, Kacie Riley, Victoria Klee, Laurence E Walsh, Matthias Begemann, Miriam Elbracht, Thomas Eggermann, Arzu Stoppe, Kyra Stuurman, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Maureen S Mulhern, Tristan T Sands, Cheryl Cytrynbaum, Rosanna Weksberg, Federica Isidori, Tommaso Pippucci, Giulia Severi, Francesca Montanari, Michael C Kruer, Somayeh Bakhtiari, Hossein Darvish, Heiko Reutter, Gregor Hagelueken, Matthias Geyer, Adrian S Woolf, Jennifer E Posey, James R Lupski, Benjamin Odermatt, Alina C Hilger

All publications by PD Dr. Gregor Hagelüken