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PD Dr. Gregor Hagelüken

Member

Institute of Structural Biology

University Bonn, Institute of Structural Biology, Sigmund-Freud-Str. 25, D-53127 Bonn

hagelueken@uni-bonn.de

+49 228 28751200

Website

The research in my group focuses on two related topics. The first topic is bacterial immunity. The discovery of CRISPR defense systems has shown that bacteria have very complicated immune systems that protect the microorganisms from attack by phages, i.e. viruses that are specialized to infect bacteria. In addition to CRISPR, there are many other bacterial defense systems, many of which are strikingly similar to parts of the human immune system.
The second theme is the interface between pathogens and our immune system, such as the tricks that pathogens use to evade the latter. One example is a process by which pathogens such as Haemophilus influenzae scavenge a sugar molecule called sialic acid from our tissues and incorporate it into their cell wall to hide from our immune system.
Using general biochemistry and structural biology, we are trying to understand these systems and learn about the origin and function of our immune system.

Gregor Hagelüken

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Recent publications

  • AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.

    Nature communications

    Authors: Bianca Broske, Benjamin A McEnroe, Sophie C Frechen, Tim N Kempchen, Caroline I Fandrey, Elisabeth Tan, Dominic Ferber, Michelle C R Yong, Marie Kleinert, Julia M Messmer, Peter Konopka, Alexander Hoch, Katja Blumenstock, Jan M P Tödtmann, Johannes Oldenburg, Heiko Rühl, Alexander Semaan, Marieta I Toma, Kristina Markova, Sebastian Kobold, Tim Rollenske, Matthias Geyer, Stephan Menzel, Tobias Bald, Jonathan L Schmid-Burgk, Gregor Hagelueken, Michael Hölzel

  • Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor.

    Nature communications

    Authors: Jessica Nagel, Vigneshwaran Namasivayam, Stephanie Weinhausen, Juan Sierra-Marquez, Younis Baqi, Hashem Ali M Al Musawi, Aliaa Abdelrahman, Victoria J Vaaßen, Jonathan G Schlegel, Lisa Taplick, Jane Torp, Jan Kubicek, Barbara Maertens, Matthias Geyer, Tobias Claff, Annette Nicke, Gregor Hagelueken, Christa E Müller

  • Specificity and mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    Authors: Svetlana Belukhina, Baptiste Saudemont, Florence Depardieu, Tom Lorthios, Tinashe P Maviza, Alexei Livenskyi, Marina Serebryakova, Maria Aleksandrova, Elizaveta Ukholkina, Nadezhda Burmistrova, Petr Sergiev, Marouane Libiad, Sarah Dubrac, Frederic Barras, Yuri Motorin, Virginie Marchand, Gregor Hagelueken, Artem Isaev, David Bikard, Christophe Rouillon

All publications by PD Dr. Gregor Hagelüken