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featured publications

  • AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.

    Nature communications

    Authors: Bianca Broske, Benjamin A McEnroe, Sophie C Frechen, Tim N Kempchen, Caroline I Fandrey, Elisabeth Tan, Dominic Ferber, Michelle C R Yong, Marie Kleinert, Julia M Messmer, Peter Konopka, Alexander Hoch, Katja Blumenstock, Jan M P Tödtmann, Johannes Oldenburg, Heiko Rühl, Alexander Semaan, Marieta I Toma, Kristina Markova, Sebastian Kobold, Tim Rollenske, Matthias Geyer, Stephan Menzel, Tobias Bald, Jonathan L Schmid-Burgk, Gregor Hagelueken, Michael Hölzel

  • Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor.

    Nature communications

    Authors: Jessica Nagel, Vigneshwaran Namasivayam, Stephanie Weinhausen, Juan Sierra-Marquez, Younis Baqi, Hashem Ali M Al Musawi, Aliaa Abdelrahman, Victoria J Vaaßen, Jonathan G Schlegel, Lisa Taplick, Jane Torp, Jan Kubicek, Barbara Maertens, Matthias Geyer, Tobias Claff, Annette Nicke, Gregor Hagelueken, Christa E Müller

  • Specificity and mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system.

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    Authors: Svetlana Belukhina, Baptiste Saudemont, Florence Depardieu, Tom Lorthios, Tinashe P Maviza, Alexei Livenskyi, Marina Serebryakova, Maria Aleksandrova, Elizaveta Ukholkina, Nadezhda Burmistrova, Petr Sergiev, Marouane Libiad, Sarah Dubrac, Frederic Barras, Yuri Motorin, Virginie Marchand, Gregor Hagelueken, Artem Isaev, David Bikard, Christophe Rouillon

  • Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models.

    European journal of human genetics : EJHG

    Authors: Nina Ishorst, Selina Hölzel, Carola Greve, Öznur Yilmaz, Tobias Lindenberg, Jessica Lambertz, Dmitriy Drichel, Berina Zametica, Enrico Mingardo, Jeshurun C Kalanithy, Khadija Channab, Duygu Kibris, Sabrina Henne, Franziska Degenhardt, Anna Siewert, Michael Dixon, Teresa Kruse, Edwin Ongkosuwito, Katta M Girisha, Shruti Pande, Stefanie Nowak, Gregor Hagelueken, Matthias Geyer, Carine Carels, Iris A L M van Rooij, Kerstin U Ludwig, Benjamin Odermatt, Elisabeth Mangold

  • Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein.

    Communications biology

    Authors: Niels Schneberger, Philipp Hendricks, Martin F Peter, Erik Gehrke, Sophie C Binder, Paul-Albert Koenig, Stephan Menzel, Gavin H Thomas, Gregor Hagelueken

  • Cryo-EM structure of the human native plasma coagulation factor XIII complex.

    Blood

    Authors: Sneha Singh, Gregor Hagelueken, Deniz Ugurlar, Samhitha Urs Ramaraje Urs, Amit Sharma, Manoranjan Mahapatra, Friedel Drepper, Diana Imhof, Pitter F Huesgen, Johannes Oldenburg, Matthias Geyer, Arijit Biswas

  • Pulse EPR Methods in the Angstrom to Nanometre Scale Shed Light on the Conformational Flexibility of a Fluoride Riboswitch.

    Angewandte Chemie (International ed. in English)

    Authors: Laura Remmel, Andreas Meyer, Katrin Ackermann, Gregor Hagelueken, Marina Bennati, Bela E Bode

  • The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease.

    Nucleic acids research

    Authors: Sophie C Binder, Niels Schneberger, Maximilian Schmitz, Marianne Engeser, Matthias Geyer, Christophe Rouillon, Gregor Hagelueken

  • Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies.

    NPJ genomic medicine

    Authors: Jil D Stegmann, Jeshurun C Kalanithy, Gabriel C Dworschak, Nina Ishorst, Enrico Mingardo, Filipa M Lopes, Yee Mang Ho, Phillip Grote, Tobias T Lindenberg, Öznur Yilmaz, Khadija Channab, Steve Seltzsam, Shirlee Shril, Friedhelm Hildebrandt, Felix Boschann, André Heinen, Angad Jolly, Katherine Myers, Kim McBride, Mir Reza Bekheirnia, Nasim Bekheirnia, Marcello Scala, Manuela Morleo, Vincenzo Nigro, Annalaura Torella, Michele Pinelli, Valeria Capra, Andrea Accogli, Silvia Maitz, Alice Spano, Rory J Olson, Eric W Klee, Brendan C Lanpher, Se Song Jang, Jong-Hee Chae, Philipp Steinbauer, Dietmar Rieder, Andreas R Janecke, Julia Vodopiutz, Ida Vogel, Jenny Blechingberg, Jennifer L Cohen, Kacie Riley, Victoria Klee, Laurence E Walsh, Matthias Begemann, Miriam Elbracht, Thomas Eggermann, Arzu Stoppe, Kyra Stuurman, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Maureen S Mulhern, Tristan T Sands, Cheryl Cytrynbaum, Rosanna Weksberg, Federica Isidori, Tommaso Pippucci, Giulia Severi, Francesca Montanari, Michael C Kruer, Somayeh Bakhtiari, Hossein Darvish, Heiko Reutter, Gregor Hagelueken, Matthias Geyer, Adrian S Woolf, Jennifer E Posey, James R Lupski, Benjamin Odermatt, Alina C Hilger

  • Conformational coupling of the sialic acid TRAP transporter HiSiaQM with its substrate binding protein HiSiaP.

    Nature communications

    Authors: Martin F Peter, Jan A Ruland, Yeojin Kim, Philipp Hendricks, Niels Schneberger, Jan Peter Siebrasse, Gavin H Thomas, Ulrich Kubitscheck, Gregor Hagelueken