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Prof. Dr. Aleksandra Pandyra

Member

Clinical Chemistry and Clinical Pharmacology

Zone North, Building B12, Room 409 Venusberg-Campus 1 53127 Bonn

apandyr1@uni-bonn.de

+49 228 28751971

Our laboratory uses in vivo models to investigate anti-tumoral and anti-viral immune responses and exploits them to uncover novel immune boosting therapies. The pre-clinical translational aims of our research focus on discovering novel immunomodulatory repurposing candidates that reduce the deleterious effects of chronic viral infections and malignant tumors. For example, using an ex vivo screening strategy where T cells were co-cultured with tumor cells, we identified 5-Nonyloxytryptamine (5-NL), a serotonin agonist, as increasing the ability of T cells to target tumor cells through induction of MHC-I expression. Ultimately, we aim to boost the body’s immune system to counteract the effects of an immunosuppressive tumor microenvironment which often impedes immunotherapeutic treatment and supports tumor progression. Further integral to our work is dissecting how vaccine-induced immune training modulates the TME and the key components shaping its plasticity including myeloid infiltrating immune cells. Our work focuses on poorly immunogenic tumors including childhood leukemia due to the integral role that the untrained immune system plays in its initiation.

Aleksandra Pandyra

Recent publications

  • Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in myeloid leukemia cells.

    Cell death & disease

    Authors: Julian Schliehe-Diecks, Jia-Wey Tu, Pawel Stachura, Katerina Schaal, Marie Kemkes, Eleni Vasileiou, Nadine Rüchel, Danielle Brandes, Melina Vogt, Thomas Lenz, Adarsh Nair, Stefanie Scheu, Pilar M Dominguez, Agata Pastorczak, Karin Nebral, Kai Stühler, Ute Fischer, Aleksandra A Pandyra, Arndt Borkhardt, Sanil Bhatia

  • Serum-free differentiation platform for the generation of B lymphocytes and natural killer cells from human CD34+ cord blood progenitors.

    Scientific reports

    Authors: Rigveda Bhave, Carla-Johanna Kath, Nadine Rüchel, Eleni Vasileiou, Vera H Jepsen, Katharina Raba, Aleksandra A Pandyra, Ute Fischer, Gesine Kogler

  • Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL

    Cell Death and Disease

    Authors: Stachura P, Lu Z, Kronberg RM, Xu HC, Liu W, Tu JW, Schaal K, Kameri E, Picard D, von Karstedt S, Fischer U, Bhatia S, Lang PA, Borkhardt A, Pandyra AA

All publications by Prof. Dr. Aleksandra Pandyra