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Prof. Dr. Eicke Latz

Member

Institute of Innate Immunity

Medical Faculty, University of Bonn University Hospital of Bonn Biomedical Center, 1G007 Sigmund-Freud-Strasse 25 53127 Bonn

eicke.latz@uni-bonn.de

+49 1515 8233370

Website

The Latz Lab has a longstanding interest in deciphering the molecular
mechanisms of innate immune receptor activation. In particular, the lab
is interested in understanding how innate receptors interact with their
ligands and how this molecular interaction leads to receptor activation.
Recently, we have also focused on the molecular details of the
mechanisms that lead to the activation of the NLRP3 and AIM2
inflammasome. The NLRP3 inflammasome can respond to a broad range of
cellular stressors and to substances that indicate metabolic
derangements such as aggregated peptides, crystals of monosodium urate
(forming in gout) or crystals of cholesterol that are found in
atherosclerotic plaques. One goal of the research is to translate the
molecular understanding of innate immune receptor activation into the
generation of molecular tools that could lead to the development of
specific diagnostics for inflammatory materials. Another goal is to
devise means to pharmacologically interfere with the activation of
innate immune receptors in order to develop novel approaches to treat
inflammatory diseases such as Alzheimer’s disease or atherosclerosis.

Eicke Latz

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Recent publications

  • NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms.

    Nature communications

    Authors: Ruth-Miriam Koerber, Calvin Krollmann, Kevin Cieslak, Elisabeth Tregel, Maria L Saenz, Tim H Brümmendorf, Steffen Koschmieder, Martin Griesshammer, Ines Gütgemann, Conny K Baldauf, Thomas Fischer, Peter Brossart, Carl Christian Kolbe, Eicke Latz, Dominik Wolf, Lino L Teichmann

  • Enhancing Tyro3 signalling ameliorates IL-1β production through STAT1 in Alzheimer's disease models.

    Journal of leukocyte biology

    Authors: Kishore Aravind Ravichandran, Frederic Brosseron, Róisín M McManus, Christina Ising, Simon Görgen, Susanne Schmidt, Fracesco Santarelli, Se Young Lee, Hyuncheol Jung, Won-Suk Chung, Chan Hyuk Kim, Agustin Ruiz Laza, Carmen Ruiz de Almodóvar, Alfredo Ramirez, Eicke Latz, Michael T Heneka

  • The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets.

    Nature immunology

    Authors: Alexander N R Weber, Róisín M McManus, Veit Hornung, Matthias Geyer, Jasmin B Kuemmerle-Deschner, Eicke Latz

All publications by Prof. Dr. Eicke Latz