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Prof. Dr. Eicke Latz

Member

Institute of Innate Immunity

Medical Faculty, University of Bonn University Hospital of Bonn Biomedical Center, 1G007 Sigmund-Freud-Strasse 25 53127 Bonn

eicke.latz@uni-bonn.de

+49 1515 8233370

Website

The Latz Lab has a longstanding interest in deciphering the molecular
mechanisms of innate immune receptor activation. In particular, the lab
is interested in understanding how innate receptors interact with their
ligands and how this molecular interaction leads to receptor activation.
Recently, we have also focused on the molecular details of the
mechanisms that lead to the activation of the NLRP3 and AIM2
inflammasome. The NLRP3 inflammasome can respond to a broad range of
cellular stressors and to substances that indicate metabolic
derangements such as aggregated peptides, crystals of monosodium urate
(forming in gout) or crystals of cholesterol that are found in
atherosclerotic plaques. One goal of the research is to translate the
molecular understanding of innate immune receptor activation into the
generation of molecular tools that could lead to the development of
specific diagnostics for inflammatory materials. Another goal is to
devise means to pharmacologically interfere with the activation of
innate immune receptors in order to develop novel approaches to treat
inflammatory diseases such as Alzheimer’s disease or atherosclerosis.

Eicke Latz

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Recent publications

  • Local albumin excess exacerbates Candida albicans-induced inflammasome activation linked with hyperinflammation during vulvovaginal candidiasis.

    Nature communications

    Authors: Sophie Austermeier, Kar On Cheng, Axel Dietschmann, Gianluca Vascelli, Dolly E Montaño, Sophia U J Hitzler, Kira S Skurk, Candela Fernández-Fernández, Saloni Saloni, Stefanie Westermann, Martin Jaeger, Nadja Jablonowski, Stephanie Wisgott, Osama Elshafee, Chiara Brachelente, Dennis M de Graaf, Tomasz Próchnicki, Eicke Latz, Stefan Wirtz, Christoph Becker, Giorgia Renga, Vasileios Oikonomou, Bernhard Hube, Gilbert G G Donders, Marina Pekmezovic, Teresa Zelante, Mark S Gresnigt

  • Molecular underpinnings of rheumatic diseases and emerging therapeutic concepts.

    Nature

    Authors: Gerhard Krönke, Georg Schett, Eicke Latz

  • Author Correction: Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

    Nature

    Authors: Andrea Ablasser, Jonathan L Schmid-Burgk, Inga Hemmerling, Gabor L Horvath, Tobias Schmidt, Eicke Latz, Veit Hornung

All publications by Prof. Dr. Eicke Latz