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Prof. Dr. Eicke Latz

Member, Steering-Committee Member

Institute of Innate Immunity

Medical Faculty, University of Bonn University Hospital of Bonn Biomedical Center, 1G007 Sigmund-Freud-Strasse 25 53127 Bonn

+49 1515 8233370


The Latz Lab has a longstanding interest in deciphering the molecular
mechanisms of innate immune receptor activation. In particular, the lab
is interested in understanding how innate receptors interact with their
ligands and how this molecular interaction leads to receptor activation.
Recently, we have also focused on the molecular details of the
mechanisms that lead to the activation of the NLRP3 and AIM2
inflammasome. The NLRP3 inflammasome can respond to a broad range of
cellular stressors and to substances that indicate metabolic
derangements such as aggregated peptides, crystals of monosodium urate
(forming in gout) or crystals of cholesterol that are found in
atherosclerotic plaques. One goal of the research is to translate the
molecular understanding of innate immune receptor activation into the
generation of molecular tools that could lead to the development of
specific diagnostics for inflammatory materials. Another goal is to
devise means to pharmacologically interfere with the activation of
innate immune receptors in order to develop novel approaches to treat
inflammatory diseases such as Alzheimer’s disease or atherosclerosis.

Recent publications

  • Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies.

    Cellular & molecular immunology

    Authors: Yufang Shi, Andreas Strasser, Douglas R Green, Eicke Latz, Alberto Mantovani, Gerry Melino

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  • From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists.

    Scientific data

    Authors: Lea Seep, Stephan Grein, Iva Splichalova, Danli Ran, Mickel Mikhael, Staffan Hildebrand, Mario Lauterbach, Karsten Hiller, Dalila Juliana Silva Ribeiro, Katharina Sieckmann, Ronja Kardinal, Hao Huang, Jiangyan Yu, Sebastian Kallabis, Janina Behrens, Andreas Till, Viktoriya Peeva, Akim Strohmeyer, Johanna Bruder, Tobias Blum, Ana Soriano-Arroquia, Dominik Tischer, Katharina Kuellmer, Yuanfang Li, Marc Beyer, Anne-Kathrin Gellner, Tobias Fromme, Henning Wackerhage, Martin Klingenspor, Wiebke K Fenske, Ludger Scheja, Felix Meissner, Andreas Schlitzer, Elvira Mass, Dagmar Wachten, Eicke Latz, Alexander Pfeifer, Jan Hasenauer

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  • Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids.


    Authors: Jean-Philippe Auger, Max Zimmermann, Maria Faas, Ulrich Stifel, David Chambers, Brenda Krishnacoumar, R Verena Taudte, Charlotte Grund, Gitta Erdmann, Carina Scholtysek, Stefan Uderhardt, Oumaima Ben Brahim, Mónica Pascual Maté, Cornelia Stoll, Martin Böttcher, Katrin Palumbo-Zerr, Matthew S J Mangan, Maria Dzamukova, Markus Kieler, Melanie Hofmann, Stephan Blüml, Gernot Schabbauer, Dimitrios Mougiakakos, Uwe Sonnewald, Fabian Hartmann, David Simon, Arnd Kleyer, Anika Grüneboom, Susetta Finotto, Eicke Latz, Jörg Hofmann, Georg Schett, Jan Tuckermann, Gerhard Krönke

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