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Prof. Dr. Eicke Latz

Member, Steering-Committee Member

Institute of Innate Immunity

Medical Faculty, University of Bonn University Hospital of Bonn Biomedical Center, 1G007 Sigmund-Freud-Strasse 25 53127 Bonn

+49 1515 8233370


The Latz Lab has a longstanding interest in deciphering the molecular
mechanisms of innate immune receptor activation. In particular, the lab
is interested in understanding how innate receptors interact with their
ligands and how this molecular interaction leads to receptor activation.
Recently, we have also focused on the molecular details of the
mechanisms that lead to the activation of the NLRP3 and AIM2
inflammasome. The NLRP3 inflammasome can respond to a broad range of
cellular stressors and to substances that indicate metabolic
derangements such as aggregated peptides, crystals of monosodium urate
(forming in gout) or crystals of cholesterol that are found in
atherosclerotic plaques. One goal of the research is to translate the
molecular understanding of innate immune receptor activation into the
generation of molecular tools that could lead to the development of
specific diagnostics for inflammatory materials. Another goal is to
devise means to pharmacologically interfere with the activation of
innate immune receptors in order to develop novel approaches to treat
inflammatory diseases such as Alzheimer’s disease or atherosclerosis.

Recent publications

  • Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model.

    Cell reports

    Authors: Brendon D Parsons, Daniel Medina-Luna, Michal Scur, Marinella Pinelli, Gayani S Gamage, Rebecca A Chilvers, Yannick Hamon, Ibrahim H I Ahmed, Stéphane Savary, Andrew P Makrigiannis, Nancy E Braverman, Juan F Rodriguez-Alcazar, Eicke Latz, Tobias K Karakach, Francesca Di Cara

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  • Cholesterol Crystal Dissolution Rate of Serum Predicts Outcomes in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

    Journal of the American Heart Association

    Authors: Baravan Al-Kassou, Lara Al-Kassou, Thorsten Mahn, Dieter Lütjohann, Jasmin Shamekhi, Nicola Willemsen, Sven Thomas Niepmann, Stephan Baldus, Malte Kelm, Georg Nickenig, Eicke Latz, Sebastian Zimmer

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  • UNC93B1 variants underlie TLR7-dependent autoimmunity.

    Science immunology

    Authors: Christine Wolf, Ee Lyn Lim, Mohammad Mokhtari, Barbara Kind, Alexandru Odainic, Eusebia Lara-Villacanas, Sarah Koss, Simon Mages, Katharina Menzel, Kerstin Engel, Gregor Dückers, Benedikt Bernbeck, Dominik T Schneider, Kathrin Siepermann, Tim Niehues, Carl Christoph Goetzke, Pawel Durek, Kirsten Minden, Thomas Dörner, Anna Stittrich, Franziska Szelinski, Gabriela Maria Guerra, Mona Massoud, Markus Bieringer, Carina C de Oliveira Mann, Eduardo Beltrán, Tilmann Kallinich, Mir-Farzin Mashreghi, Susanne V Schmidt, Eicke Latz, Johanna Klughammer, Olivia Majer, Min Ae Lee-Kirsch

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