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Prof. Dr. Hiroki Kato

Member, Steering-Committee Member

Institute of Cardiovascular Immunology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

hkato@uni-bonn.de

Website

My research focuses on the mechanisms by which cytoplasmic RNA sensors RIG-I like receptors (RLRs) distinguish between viral RNAs and self-RNAs and trigger type I IFNs. Current work examines spontaneous autoimmune symptoms in RLR mutant mice derived via mutagenesis and how RLR-dysregulation causes autoimmune disease. I am also particularly interested in the analysis of immune responses and pathogenesis in virus infection in vivo and autoimmune diseases using mouse models.

Hiroki Kato

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Recent publications

  • Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion.

    Developmental cell

    Authors: Akihito Kira, Ichiko Tatsutomi, Keisuke Saito, Machiko Murata, Izumi Hattori, Haruna Kajita, Naoko Muraki, Yukako Oda, Saya Satoh, Yuta Tsukamoto, Seisuke Kimura, Kenta Onoue, Shigenobu Yonemura, Satoko Arakawa, Hiroki Kato, Tsuyoshi Hirashima, Kohki Kawane

  • Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I.

    Scientific reports

    Authors: Jung Hyun Im, Ivana Duic, Shige H Yoshimura, Koji Onomoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita

  • Top publication

    Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.

    Science (New York, N.Y.)

    Authors: Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja Vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H Christensen, Yonas M Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E Müller, Manabu Igarashi, Hiroki Kato

All publications by Prof. Dr. Hiroki Kato