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Prof. Dr. Hiroki Kato

Member, Steering-Committee Member

Institute of Cardiovascular Immunology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

hkato@uni-bonn.de

Website

My research focuses on the mechanisms by which cytoplasmic RNA sensors RIG-I like receptors (RLRs) distinguish between viral RNAs and self-RNAs and trigger type I IFNs. Current work examines spontaneous autoimmune symptoms in RLR mutant mice derived via mutagenesis and how RLR-dysregulation causes autoimmune disease. I am also particularly interested in the analysis of immune responses and pathogenesis in virus infection in vivo and autoimmune diseases using mouse models.

Hiroki Kato

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Recent publications

  • Pathogenic GM-CSF drives functional diversification of inflammatory macrophages in autoimmune arthritis.

    Science advances

    Authors: Hiroki Mukoyama, Yusuke Takeuchi, Daiya Ohara, Yoonha Lee, Hitomi Watanabe, Hiroki Kato, Gen Kondoh, Akio Morinobu, Keiji Hirota

  • Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200 Egr2 arthritogenic Th17 cells.

    Nature immunology

    Authors: Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Yuji Nishimura, Takeshi Iwasaki, Shohei Hori, Hiroshi Kawamoto, Hiroki Kato, Gen Kondoh, Akio Morinobu, Tsuneyo Mimori, Keiji Hirota

  • A 20-amino-acid Cardiovirus protein exhibits cytokine-mimicry activity to regulate viral replication.

    Cell reports

    Authors: Yutaro Shirasaka, Fumihiko Takeuchi, Satoshi Koike, Hiroki Kato, Takashi Fujita

All publications by Prof. Dr. Hiroki Kato