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Publications

featured publications

  • Loss of type I interferon signaling in Kupffer cells triggers viral spread and fatal liver damage in a mouse model of Crimean-Congo hemorrhagic fever.

    PLoS pathogens

    Authors: Shintaro Yamada, Masayuki Shimojima, Takeshi Saito, Junki Maruyama, Hiroki Kato

  • Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

    Nature neuroscience

    Authors: Xin Yan, Christina Georgopoulou, Hang-Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao, Shobhit Agrawal, Sophie Crux, Andrew W Daman, Lena Wischhof, Miriam Stork, Margit Zweyer, Emma Dorotea Zanfi, Manon Chevallot-Beroux, Yunxiao Li, Elena De-Domenico, Dina Hüsson, Lorenzo Bonaguro, Yuanfang Li, Jonas Schulte-Schrepping, Qingyi Liang, Ketty Kessler, Dan Ehninger, Shahin Rafii, Jiankai Luo, Andreas Hermann, Annett Halle, Ying Liu, Elvira Mass, Melania Capasso, Hiroki Kato, Joachim L Schultze, Pierluigi Nicotera, Daniele Bano, Steven Zvi Josefowicz, Martin Fuhrmann, Thomas Ulas, Marc Beyer, Juntang Lin, Monique M B Breteler, N Ahmad Aziz, Paolo Salomoni

  • Pathogenic GM-CSF drives functional diversification of inflammatory macrophages in autoimmune arthritis.

    Science advances

    Authors: Hiroki Mukoyama, Yusuke Takeuchi, Daiya Ohara, Yoonha Lee, Hitomi Watanabe, Hiroki Kato, Gen Kondoh, Akio Morinobu, Keiji Hirota

  • Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200 Egr2 arthritogenic Th17 cells.

    Nature immunology

    Authors: Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Yuji Nishimura, Takeshi Iwasaki, Shohei Hori, Hiroshi Kawamoto, Hiroki Kato, Gen Kondoh, Akio Morinobu, Tsuneyo Mimori, Keiji Hirota

  • A 20-amino-acid Cardiovirus protein exhibits cytokine-mimicry activity to regulate viral replication.

    Cell reports

    Authors: Yutaro Shirasaka, Fumihiko Takeuchi, Satoshi Koike, Hiroki Kato, Takashi Fujita

  • Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis.

    Science immunology

    Authors: Saya Satoh, Yaw Bia Tan, Benjamin Heil, Shintaro Yamada, Verena Schütte, Celest Phang, Chaozhi Tang, Yuta Tsukamoto, Takahiro Higuchi, Takashi Fujita, Rayk Behrendt, Martin Schlee, Dahai Luo, Hiroki Kato

  • RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.

    The EMBO journal

    Authors: Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

  • Mouse models of type I interferonopathies.

    Human molecular genetics

    Authors: Domnica Luca, Hiroki Kato

  • Soluble form of the MDA5 protein in human sera.

    Heliyon

    Authors: Masaki Okamoto, Yoshiaki Zaizen, Shinjiro Kaieda, Takashi Nouno, Takuma Koga, Goushi Matama, Masahiro Mitsuoka, Jun Akiba, Shintaro Yamada, Hiroki Kato, Tomoaki Hoshino

  • Physiological functions of RIG-I-like receptors.

    Immunity

    Authors: Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita