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  • Nsp16 shields SARS-CoV-2 from efficient MDA5 sensing and IFIT1-mediated restriction.

    EMBO reports

    Authors: Alina Russ, Sabine Wittmann, Yuta Tsukamoto, Alexandra Herrmann, Janina Deutschmann, Justine Lagisquet, Armin Ensser, Hiroki Kato, Thomas Gramberg

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  • Melatonin suppresses the antiviral immune response to EMCV infection through intracellular ATP deprivation caused by mitochondrial fragmentation.

    Heliyon

    Authors: Mariko Kikuchi, Miki Kadena, Haruka Fukamachi, Takashi Takaki, Shohei Matsui, Sumire Hoashi-Takiguchi, Hirobumi Morisaki, Nataša Trtić, Mina Mori, Mie Kurosawa, Momoe Itsumi, Takahiro Funatsu, Atsuo Sakurai, Seikou Shintani, Hiroki Kato, Takashi Fujita, Yasubumi Maruoka, Hirotaka Kuwata

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  • Correction: PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis.

    Cell death & disease

    Authors: Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujita

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  • Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model.

    Biochemical and biophysical research communications

    Authors: Sumin Lee, Keiji Hirota, Verena Schuette, Takashi Fujita, Hiroki Kato

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  • PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis.

    Cell death & disease

    Authors: Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujita

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  • Publication categories: Top publication

    Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19.

    Nature

    Authors: Fotios Karagiannis, Konrad Peukert, Laura Surace, Marcel Michla, Fabian Nikolka, Mario Fox, Patricia Weiss, Caroline Feuerborn, Paul Maier, Susanne Schulz, Burcu Al, Benjamin Seeliger, Tobias Welte, Sascha David, Inge Grondman, Aline H de Nooijer, Peter Pickkers, Jan Lukas Kleiner, Marc Moritz Berger, Thorsten Brenner, Christian Putensen, Hiroki Kato, Natalio Garbi, Mihai G Netea, Karsten Hiller, Katarzyna Placek, Christian Bode, Christoph Wilhelm

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  • Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases.

    The EMBO journal

    Authors: Valter Bergant, Shintaro Yamada, Vincent Grass, Yuta Tsukamoto, Teresa Lavacca, Karsten Krey, Maria-Teresa Mühlhofer, Sabine Wittmann, Armin Ensser, Alexandra Herrmann, Anja Vom Hemdt, Yuriko Tomita, Shutoku Matsuyama, Takatsugu Hirokawa, Yiqi Huang, Antonio Piras, Constanze A Jakwerth, Madlen Oelsner, Susanne Thieme, Alexander Graf, Stefan Krebs, Helmut Blum, Beate M Kümmerer, Alexey Stukalov, Carsten B Schmidt-Weber, Manabu Igarashi, Thomas Gramberg, Andreas Pichlmair, Hiroki Kato

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  • The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter.

    Scientific reports

    Authors: Wilaiporn Saikruang, Lena Ang Yan Ping, Hiroto Abe, Dacquin M Kasumba, Hiroki Kato, Takashi Fujita

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  • RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection.

    Molecular therapy. Nucleic acids

    Authors: Samira Marx, Beate M Kümmerer, Christian Grützner, Hiroki Kato, Martin Schlee, Marcel Renn, Eva Bartok, Gunther Hartmann

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  • Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis.

    Journal of autoimmunity

    Authors: Taisuke Ohto, Ahmed Abu Tayeh, Ryuta Nishikomori, Hiroto Abe, Kyota Hashimoto, Shiro Baba, Anahi-Paula Arias-Loza, Nobumasa Soda, Saya Satoh, Masashi Matsuda, Yusuke Iizuka, Takashi Kondo, Haruhiko Koseki, Nan Yan, Takahiro Higuchi, Takashi Fujita, Hiroki Kato

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