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Prof. Dr. Jan Hasenauer

Member, Steering-Committee Member

Life and Medical Sciences Institute (LIMES) and Hausdorff Center for Mathematics

Hausdorff Center for Mathematics - HCM Room 2.003 Villa Maria, Endenicher Allee 64 53115 Bonn

jan.hasenauer@uni-bonn.de

+49 228 7369446

Website

Our interdisciplinary research unit develops and applies computational methods for the analysis of complex biological processes. We focus on methods facilitating the model-based integration of different datasets, the critical assessment of the availableinformation, the comparison of competing biological hypothesis and the tailored selection of future experiments. Following thephilosophy of Galileo Galilei: "Measure what can be measured, and make measurable what cannot be measured.", we usemodels to reconstruct properties of the system which cannot be assessed experimentally. This results in an improved holisticunderstanding of biological systems. We apply these methods to study cellular signal processing, cell-to-cell variability, and tissueorganisation.

Recent publications

  • Data-driven model reveals increased stability of CAG-expanded huntingtin RNA due to MID1 binding.

    PLoS computational biology

    Authors: Yuhong Liu, Annika Reisbitzer, Domagoj Dorešić, Jan Hasenauer, Sybille Krauß, Tatjana Tchumatchenko

  • Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions.

    Science (New York, N.Y.)

    Authors: Clivia Lisowski, Michael Quetting, Daniela Klaus, Lisa Lazarevski, Lea Seep, Maximilian Germer, Jian Li, Inge Müller, Daniel Zuniga, Wolfgang Fiedler, Dina K N Dechmann, Kasper Thorup, Jan Hasenauer, Lars Fester, Stefanie Kuerten, Michael Farle, Ulf Wiedwald, Martin Wikelski, Christian Kurts

  • Suggested experimental design and computational modeling to infer single-cell lipid dynamics from a single destructive measurement.

    iScience

    Authors: Paul Jonas Jost, Daniel Weindl, Klaus Wunderling, Christoph Thiele, Jan Hasenauer

All publications by Prof. Dr. Jan Hasenauer