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Prof. Dr. Jan Hasenauer

Member, Steering-Committee Member

Life and Medical Sciences Institute (LIMES) and Hausdorff Center for Mathematics

Hausdorff Center for Mathematics - HCM Room 2.003 Villa Maria, Endenicher Allee 64 53115 Bonn

+49 228 7369446


Our interdisciplinary research unit develops and applies computational methods for the analysis of complex biological processes. We focus on methods facilitating the model-based integration of different datasets, the critical assessment of the availableinformation, the comparison of competing biological hypothesis and the tailored selection of future experiments. Following thephilosophy of Galileo Galilei: "Measure what can be measured, and make measurable what cannot be measured.", we usemodels to reconstruct properties of the system which cannot be assessed experimentally. This results in an improved holisticunderstanding of biological systems. We apply these methods to study cellular signal processing, cell-to-cell variability, and tissueorganisation.

Recent publications

  • pyPESTO: A modular and scalable tool for parameter estimation for dynamic models.

    Bioinformatics (Oxford, England)

    Authors: Yannik Schälte, Fabian Fröhlich, Paul J Jost, Jakob Vanhoefer, Dilan Pathirana, Paul Stapor, Polina Lakrisenko, Dantong Wang, Elba Raimúndez, Simon Merkt, Leonard Schmiester, Philipp Städter, Stephan Grein, Erika Dudkin, Domagoj Doresic, Daniel Weindl, Jan Hasenauer

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  • FitMultiCell: Simulating and parameterizing computational models of multi-scale and multi-cellular processes.

    Bioinformatics (Oxford, England)

    Authors: Emad Alamoudi, Yannik Schälte, Robert Müller, Jörn Starruß, Nils Bundgaard, Frederik Graw, Lutz Brusch, Jan Hasenauer

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  • Retest variability and patient reliability indices of quantitative fundus autofluorescence in age-related macular degeneration: a MACUSTAR study report.

    Scientific reports

    Authors: Leon von der Emde, Merten Mallwitz, Marc Vaisband, Jan Hasenauer, Marlene Saßmannshausen, Jan Henrik Terheyden, Kenneth R Sloan, Steffen Schmitz-Valckenberg, Robert P Finger, Frank G Holz, Thomas Ach

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