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Prof. Dr. Jan Hasenauer

Member, Steering-Committee Member

Life and Medical Sciences Institute (LIMES) and Hausdorff Center for Mathematics

Hausdorff Center for Mathematics - HCM Room 2.003 Villa Maria, Endenicher Allee 64 53115 Bonn

+49 228 7369446


Our interdisciplinary research unit develops and applies computational methods for the analysis of complex biological processes. We focus on methods facilitating the model-based integration of different datasets, the critical assessment of the availableinformation, the comparison of competing biological hypothesis and the tailored selection of future experiments. Following thephilosophy of Galileo Galilei: "Measure what can be measured, and make measurable what cannot be measured.", we usemodels to reconstruct properties of the system which cannot be assessed experimentally. This results in an improved holisticunderstanding of biological systems. We apply these methods to study cellular signal processing, cell-to-cell variability, and tissueorganisation.

Recent publications

  • Efficient parameter estimation for ODE models of cellular processes using semi-quantitative data.

    Bioinformatics (Oxford, England)

    Authors: Domagoj Dorešić, Stephan Grein, Jan Hasenauer

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  • Missing data in amortized simulation-based neural posterior estimation.

    PLoS computational biology

    Authors: Zijian Wang, Jan Hasenauer, Yannik Schälte

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  • Evolution of protective SARS-CoV-2-specific B and T cell responses upon vaccination and Omicron breakthrough infection.


    Authors: Mohamed I M Ahmed, Sebastian Einhauser, Clemens Peiter, Antonia Senninger, Olga Baranov, Tabea M Eser, Manuel Huth, Laura Olbrich, Noemi Castelletti, Raquel Rubio-Acero, George Carnell, Jonathan Heeney, Inge Kroidl, Kathrin Held, Andreas Wieser, Christian Janke, Michael Hoelscher, Jan Hasenauer, Ralf Wagner, Christof Geldmacher

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