Skip to main content

Prof. Dr. Kevin Thurley

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg-Campus 1 53127 Bonn

kthurley@uni-bonn.de

Website

The mammalian immune response depends on the interaction and collaboration of many highly individual cells. Further, cells themselves are regulated by complex intracellular networks such as signal transduction and gene regulation, and cell-cell communication by diffusible ligands generates spatial signaling gradients, with far-reaching consequences for immune-cell decision making in compartments such as secondary lymphoid organs. Our group develops and applies mathematical methods for data-driven dissection of intercellular communication networks in time and space. Ultimately, we seek to derive predictive models in the context of clinical conditions such as chronic inflammation and cancer, to investigate the effects of perturbations and thus pave the road for optimization of targeted therapies in the future.

Kevin Thurley

Recent publications

  • Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism.

    Nature metabolism

    Authors: Nikola Makdissi, Maria Francesca Viola, Lisa Maria Steinheuer, Nelli Blank-Stein, Ronja Kardinal, Fabrizio Musacchio, Eliana Franco Taveras, Virginia Aliprandi, Katharina Sieckmann, Akram Abdulkadyrov, Marina L Mayer, Marie-Louise Diefenbach-Wilke, Diana Fink, Hannes Beckert, Stefan Böhmdorfer, Quentin Deveuve, Frederike J Graelmann, Katharina Mauel, Nele Kronau, Jake Thomas, David Bejarano, Andreas Schlitzer, Sandra Högler, Mohamed H Yaghmour, Joerg Heeren, Christoph Thiele, Lukas Kenner, Felix Meissner, Falk Nimmerjahn, Martin Fuhrmann, Dagmar Wachten, Kevin Thurley, Elvira Mass

  • TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro.

    Cellular & molecular immunology

    Authors: Luisa Bach, Yinshui Chang, Olin Arteaga Transito, Mohammadamin Ghasemi, Lisa Maria Steinheuer, Teresa Steffen, Elena De Domenico, Thomas Ulas, F Thomas Wunderlich, Marc D Beyer, Kevin Thurley, Dirk Baumjohann

  • Longitudinal spatial neutrophil profiling during ACT in murine melanoma reveals distinct lymph node infiltration patterns.

    NPJ systems biology and applications

    Authors: Gemma van der Voort, Maike Effern, Michelle C R Yong, Lukas Kiwitz, Roberta Turiello, Sonia Leonardelli, Susanna Ng, Dillon Corvino, Tobias Bald, Nicole Glodde, Kevin Thurley, Jan Hasenauer, Michael Hölzel

All publications by Prof. Dr. Kevin Thurley