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Prof. Dr. Kevin Thurley

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg-Campus 1 53127 Bonn

kthurley@uni-bonn.de

Website

The mammalian immune response depends on the interaction and collaboration of many highly individual cells. Further, cells themselves are regulated by complex intracellular networks such as signal transduction and gene regulation, and cell-cell communication by diffusible ligands generates spatial signaling gradients, with far-reaching consequences for immune-cell decision making in compartments such as secondary lymphoid organs. Our group develops and applies mathematical methods for data-driven dissection of intercellular communication networks in time and space. Ultimately, we seek to derive predictive models in the context of clinical conditions such as chronic inflammation and cancer, to investigate the effects of perturbations and thus pave the road for optimization of targeted therapies in the future.

Kevin Thurley

Recent publications

  • Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node.

    Cellular & molecular immunology

    Authors: Sarah-Sophie Schacht, Josefine Graffunder, Pawel Durek, Jonas Wehrenberg, Annette Siracusa, Charlotte Biese, Mir-Farzin Mashreghi, Kevin Thurley, Laura Bauer, Andreas Hutloff

  • Type I Interferon Drives a Cellular State Inert to TCR-Stimulation and Could Impede Effective T-Cell Differentiation in Cancer.

    European journal of immunology

    Authors: Dillon Corvino, Martin Batstone, Brett G M Hughes, Tim Kempchen, Susanna S Ng, Nazhifah Salim, Franziska Schneppenheim, Denise Rommel, Ananthi Kumar, Sally Pearson, Jason Madore, Lambross T Koufariotis, Lisa Maria Steinheuer, Dilan Pathirana, Kevin Thurley, Michael Hölzel, Nicholas Borcherding, Matthias Braun, Tobias Bald

  • Expression of the large amino acid transporter SLC7A5/LAT1 on immune cells is enhanced in primary sclerosing cholangitis-associated cholangiocarcinoma and correlates with poor prognosis in cholangiocarcinoma.

    Human pathology

    Authors: Vittorio Branchi, Racha Hosni, Lukas Kiwitz, Susanna Ng, Gemma van der Voort, Neila Bambi, Eileen Kleinfelder, Laura K Esser, Leona Dold, Bettina Langhans, Maria A Gonzalez-Carmona, Saskia Ting, Glen Kristiansen, Jörg C Kalff, Kevin Thurley, Michael Hölzel, Hanno Matthaei, Marieta I Toma

All publications by Prof. Dr. Kevin Thurley