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Prof. Dr. Kevin Thurley

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg-Campus 1 53127 Bonn

kthurley@uni-bonn.de

Website

The mammalian immune response depends on the interaction and collaboration of many highly individual cells. Further, cells themselves are regulated by complex intracellular networks such as signal transduction and gene regulation, and cell-cell communication by diffusible ligands generates spatial signaling gradients, with far-reaching consequences for immune-cell decision making in compartments such as secondary lymphoid organs. Our group develops and applies mathematical methods for data-driven dissection of intercellular communication networks in time and space. Ultimately, we seek to derive predictive models in the context of clinical conditions such as chronic inflammation and cancer, to investigate the effects of perturbations and thus pave the road for optimization of targeted therapies in the future.

Kevin Thurley

Recent publications

  • Amplification of autoimmune organ damage by NKp46-activated ILC1.

    Nature

    Authors: Stylianos-Iason Biniaris-Georgallis, Tom Aschman, Katerina Stergioula, Frauke Schreiber, Vajiheh Jafari, Anna Taranko, Tejal Karmalkar, Ana Kasapi, Tihana Lenac Rovis, Vedrana Jelencic, David A Bejarano, Lea Fabry, Michail Papacharalampous, Irene Mattiola, Martina Molgora, Jinchao Hou, Karolin W Hublitz, Frederik Heinrich, Gabriela Maria Guerra, Pawel Durek, Giannino Patone, Eric Lars-Helge Lindberg, Henrike Maatz, Oliver Hölsken, Gerhard Krönke, Arthur Mortha, Reinhard E Voll, Alexander J Clarke, Anja E Hauser, Marco Colonna, Kevin Thurley, Andreas Schlitzer, Christoph Schneider, Efstathios G Stamatiades, Mir-Farzin Mashreghi, Stipan Jonjic, Norbert Hübner, Andreas Diefenbach, Masatoshi Kanda, Antigoni Triantafyllopoulou

  • Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren's syndrome.

    NPJ systems biology and applications

    Authors: Gino Kwon, Annika Wiedemann, Lisa M Steinheuer, Ana-Luisa Stefanski, Franziska Szelinski, Tomas Racek, Andreas Philipp Frei, Klas Hatje, Tony Kam-Thong, David Schubert, Thomas Schindler, Thomas Dörner, Kevin Thurley

  • Distribution modeling quantifies collective T cell decision circuits in chronic inflammation.

    Science advances

    Authors: Philipp Burt, Kevin Thurley

All publications by Prof. Dr. Kevin Thurley