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Prof. Dr. Kevin Thurley

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg-Campus 1 53127 Bonn

kthurley@uni-bonn.de

Website

The mammalian immune response depends on the interaction and collaboration of many highly individual cells. Further, cells themselves are regulated by complex intracellular networks such as signal transduction and gene regulation, and cell-cell communication by diffusible ligands generates spatial signaling gradients, with far-reaching consequences for immune-cell decision making in compartments such as secondary lymphoid organs. Our group develops and applies mathematical methods for data-driven dissection of intercellular communication networks in time and space. Ultimately, we seek to derive predictive models in the context of clinical conditions such as chronic inflammation and cancer, to investigate the effects of perturbations and thus pave the road for optimization of targeted therapies in the future.

Kevin Thurley

Recent publications

  • Longitudinal spatial neutrophil profiling during ACT in murine melanoma reveals distinct lymph node infiltration patterns.

    NPJ systems biology and applications

    Authors: Gemma van der Voort, Maike Effern, Michelle C R Yong, Lukas Kiwitz, Roberta Turiello, Sonia Leonardelli, Susanna Ng, Dillon Corvino, Tobias Bald, Nicole Glodde, Kevin Thurley, Jan Hasenauer, Michael Hölzel

  • Decoding cellular population dynamics through mechanistic modelling and statistical data analysis.

    NPJ systems biology and applications

    Authors: Nissrin Alachkar, Nicholas Kwasi-Do Ohene Opoku, Nicholas A M Monk, Kevin Thurley

  • Amplification cycles through innate lymphoid cells at the onset of lupus nephritis.

    Frontiers in immunology

    Authors: Rosa L Kreider, Stylianos-Iason Biniaris-Georgallis, Bastian Grothey, Antigoni Triantafyllopoulou, Lisa M Steinheuer, Kevin Thurley

All publications by Prof. Dr. Kevin Thurley