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featured publications

  • Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node.

    Cellular & molecular immunology

    Authors: Sarah-Sophie Schacht, Josefine Graffunder, Pawel Durek, Jonas Wehrenberg, Annette Siracusa, Charlotte Biese, Mir-Farzin Mashreghi, Kevin Thurley, Laura Bauer, Andreas Hutloff

  • Type I Interferon Drives a Cellular State Inert to TCR-Stimulation and Could Impede Effective T-Cell Differentiation in Cancer.

    European journal of immunology

    Authors: Dillon Corvino, Martin Batstone, Brett G M Hughes, Tim Kempchen, Susanna S Ng, Nazhifah Salim, Franziska Schneppenheim, Denise Rommel, Ananthi Kumar, Sally Pearson, Jason Madore, Lambross T Koufariotis, Lisa Maria Steinheuer, Dilan Pathirana, Kevin Thurley, Michael Hölzel, Nicholas Borcherding, Matthias Braun, Tobias Bald

  • Expression of the large amino acid transporter SLC7A5/LAT1 on immune cells is enhanced in primary sclerosing cholangitis-associated cholangiocarcinoma and correlates with poor prognosis in cholangiocarcinoma.

    Human pathology

    Authors: Vittorio Branchi, Racha Hosni, Lukas Kiwitz, Susanna Ng, Gemma van der Voort, Neila Bambi, Eileen Kleinfelder, Laura K Esser, Leona Dold, Bettina Langhans, Maria A Gonzalez-Carmona, Saskia Ting, Glen Kristiansen, Jörg C Kalff, Kevin Thurley, Michael Hölzel, Hanno Matthaei, Marieta I Toma

  • Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4 T cells as predictors for response to integrin α4β7-blocking therapy in inflammatory bowel disease.

    Gastroenterology

    Authors: Veronika Horn, Camila A Cancino, Lisa Maria Steinheuer, Benedikt Obermayer, Konstantin Fritz, Anke L Nguyen, Kim Susan Juhran, Christina Plattner, Diana Bösel, Lotte Oldenburg, Marie Burns, Axel Ronald Schulz, Mariia Saliutina, Eleni Mantzivi, Donata Lissner, Thomas Conrad, Mir-Farzin Mashreghi, Sebastian Zundler, Elena Sonnenberg, Michael Schumann, Lea-Maxie Haag, Dieter Beule, Lukas Flatz, Zlatko Trjanoski, Geert D'Haens, Carl Weidinger, Henrik E Mei, Britta Siegmund, Kevin Thurley, Ahmed N Hegazy

  • Amplification of autoimmune organ damage by NKp46-activated ILC1.

    Nature

    Authors: Stylianos-Iason Biniaris-Georgallis, Tom Aschman, Katerina Stergioula, Frauke Schreiber, Vajiheh Jafari, Anna Taranko, Tejal Karmalkar, Ana Kasapi, Tihana Lenac Rovis, Vedrana Jelencic, David A Bejarano, Lea Fabry, Michail Papacharalampous, Irene Mattiola, Martina Molgora, Jinchao Hou, Karolin W Hublitz, Frederik Heinrich, Gabriela Maria Guerra, Pawel Durek, Giannino Patone, Eric Lars-Helge Lindberg, Henrike Maatz, Oliver Hölsken, Gerhard Krönke, Arthur Mortha, Reinhard E Voll, Alexander J Clarke, Anja E Hauser, Marco Colonna, Kevin Thurley, Andreas Schlitzer, Christoph Schneider, Efstathios G Stamatiades, Mir-Farzin Mashreghi, Stipan Jonjic, Norbert Hübner, Andreas Diefenbach, Masatoshi Kanda, Antigoni Triantafyllopoulou

  • Diffusion-limited cytokine signaling in T cell populations.

    iScience

    Authors: Patrick Brunner, Lukas Kiwitz, Lisa Li, Kevin Thurley

  • Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren's syndrome.

    NPJ systems biology and applications

    Authors: Gino Kwon, Annika Wiedemann, Lisa M Steinheuer, Ana-Luisa Stefanski, Franziska Szelinski, Tomas Racek, Andreas Philipp Frei, Klas Hatje, Tony Kam-Thong, David Schubert, Thomas Schindler, Thomas Dörner, Kevin Thurley

  • Top publication

    Distribution modeling quantifies collective T cell decision circuits in chronic inflammation.

    Science advances

    Authors: Philipp Burt, Kevin Thurley

  • Top publication

    Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells.

    Frontiers in immunology

    Authors: Philipp Burt, Michael Peine, Caroline Peine, Zuzanna Borek, Sebastian Serve, Michael Floßdorf, Ahmed N Hegazy, Thomas Höfer, Max Löhning, Kevin Thurley

  • Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells.

    Cells

    Authors: Philipp Burt, Rebecca Cornelis, Gustav Geißler, Stefanie Hahne, Andreas Radbruch, Hyun-Dong Chang, Kevin Thurley