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Prof. Dr. Marc Hübner

Member

Institute for Medical Microbiology, Immunology and Parasitology

huebner@uni-bonn.de

+49 228 28719177

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My lab focuses on different aspects of helminth (worm) infections: 1) Protective immune responses against filariae and especially the protective role of eosinophils and the contribution of extracellular DNA traps (ETosis), 2) Filarial immunomodulation and its beneficial impact on life-style diseases such as diet-induced insulin resistance, 3) Preclinical testing of drug candidates for filariasis in order to identify novel macrofilaricidal drugs in collaboration with partners from industry and not-for-profit-organizations. For these investigations we use the Litomosoides sigmodontis rodent model and perform human studies with filariasis patients in sub-Saharan Africa.

Marc Hübner

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Recent publications

  • The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity.

    Cellular & molecular immunology

    Authors: Marc P Hübner, Dennis de Coninck, Benjamin Lenz, Jayagopi Surendar, Marianne Koschel, Narcisse Victor Tchamatchoua Gandjui, Beng Amuam Andrew, Lucy Cho Nchang, Anita Obi Bate Ebob, Fanny Fri Fombad, Lisa Marie Springer, Lars Eppe, Frank A Schildberg, Samuel Wanji, Achim Hoerauf, Alexander Pfeifer, Indulekha Karunakaran

  • Mansonella perstans - the forgotten filaria.

    Trends in parasitology

    Authors: Manuel Ritter, Hsun Yun Hsu, Benjamin Lenz, Chi Anizette Kien, Narcisse Victor Tchamatchoua Gandjui, Marc P Hübner, Achim Hoerauf, Samuel Wanji

  • Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis.

    PLoS neglected tropical diseases

    Authors: Pia Philippa Schumacher, Jesuthas Ajendra, Benjamin Lenz, Frederic Risch, Alexandra Ehrens, Celia Nieto-Pérez, Marianne Koschel, Tilman Aden, Achim Hoerauf, Marc P Hübner

All publications by Prof. Dr. Marc Hübner