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Prof. Dr. Marc Hübner

Member

Institute for Medical Microbiology, Immunology and Parasitology

huebner@uni-bonn.de

+49 228 28719177

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My lab focuses on different aspects of helminth (worm) infections: 1) Protective immune responses against filariae and especially the protective role of eosinophils and the contribution of extracellular DNA traps (ETosis), 2) Filarial immunomodulation and its beneficial impact on life-style diseases such as diet-induced insulin resistance, 3) Preclinical testing of drug candidates for filariasis in order to identify novel macrofilaricidal drugs in collaboration with partners from industry and not-for-profit-organizations. For these investigations we use the Litomosoides sigmodontis rodent model and perform human studies with filariasis patients in sub-Saharan Africa.

Marc Hübner

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Recent publications

  • Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis.

    PLoS neglected tropical diseases

    Authors: Pia Philippa Schumacher, Jesuthas Ajendra, Benjamin Lenz, Frederic Risch, Alexandra Ehrens, Celia Nieto-Pérez, Marianne Koschel, Tilman Aden, Achim Hoerauf, Marc P Hübner

  • Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway.

    Cell reports

    Authors: Alexandra Ehrens, Benjamin Lenz, Celia Nieto-Pérez, Eicke Latz, Florian I Schmidt, Achim Hoerauf, Marc P Hübner

  • Differences of in vitro immune responses between patent and pre-patent Litomosoides sigmodontis-infected mice are independent of the filarial antigenic stimulus used.

    Parasitology research

    Authors: Kathrin Arndts, Anna Wiszniewsky, Anna-Lena Neumann, Katharina Wiszniewsky, Gnatoulma Katawa, Achim Hoerauf, Laura E Layland-Heni, Manuel Ritter, Marc P Hübner

All publications by Prof. Dr. Marc Hübner