Institute for Medical Microbiology, Immunology and Parasitology
My lab focuses on different aspects of helminth (worm) infections: 1) Protective immune responses against filariae and especially the protective role of eosinophils and the contribution of extracellular DNA traps (ETosis), 2) Filarial immunomodulation and its beneficial impact on life-style diseases such as diet-induced insulin resistance, 3) Preclinical testing of drug candidates for filariasis in order to identify novel macrofilaricidal drugs in collaboration with partners from industry and not-for-profit-organizations. For these investigations we use the Litomosoides sigmodontis rodent model and perform human studies with filariasis patients in sub-Saharan Africa.
