Skip to main content

Prof. Dr. Matthias Geyer

Member, Steering-Committee Member

Institute of Structural Biology

University Bonn, Department of Structural Immunology, Sigmund-Freud-Str. 25, D-53127 Bonn

matthias.geyer@uni-bonn.de

+49 228 28751400

Website

The Geyer lab is interested in the regulation of transcription and the molecular mechanisms that govern immune receptor activation. We use a variety of techniques from molecular biology and biochemistry to structural biology to analyze interaction between proteins, RNA, lipids, and ligands. The transcription cycle is regulated by cyclin-dependent kinases that phosphorylate the RNA polymerase II. We analyze the transition from transcription initiation to productive elongation in eukaryotic cells. We study the molecular and structural mechanisms that determine the activity and regulation of transcription-controlling kinases, as well as their inhibition by small molecular compounds. We recently also focused on the analysis of receptor activation of NLRP3 and forma-tion of the NLRP3/ASC/caspase inflammasome. Besides NACHT-domain containing proteins, Toll-like receptors, RIG-I and the cGAS-STING pathway mediate the immune-recogni-tion of pathogens. We aim at identifying target sites in these immune regulators that allow for the specific interference with the immune system, e.g., by small molecular compounds.

Matthias Geyer

Download biosketch

Recent publications

  • C-terminal lysine residues localise NLRP10 at lipid droplets and govern NLRP10 oligomer formation.

    EMBO reports

    Authors: Timo-Daniel Voss, Christoph Winterberg, Adrian Beck, Clarissa Gottschild, Leonie Mueller, Selina M Enayat, Matthias Geyer, Thomas A Kufer

  • Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

    Human molecular genetics

    Authors: Julia A Capecki, Helena Shkuro, Öznur Yilmaz, Lisa Schmitt, Khadija Channab, Tobias T Lindenberg, Teresa Kruse, Sarah Achterrath, Berta Crespo, Anna Siewert, Mostafa Bakhshi, Leandra Pantel, Kerstin U Ludwig, Matthias Geyer, Elisabeth Mangold, Benjamin Odermatt, Nina Ishorst

  • Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation.

    Nature communications

    Authors: María Mateo-Tórtola, Inga V Hochheiser, Gaopeng Li, Lukas Funk, Atousa Hashemi, Xiao Liu, Jane Torp, Lena Erlebach, András Szolek, Jelena Grga, Francesca Bork, Jana S Müller, Deborah Kronenberg-Versteeg, Matthias Geyer, Alexander N R Weber, Ana Tapia-Abellán

All publications by Prof. Dr. Matthias Geyer