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Prof. Dr. Matthias Geyer

Member, Steering-Committee Member

Institute of Structural Biology

University Bonn, Department of Structural Immunology, Sigmund-Freud-Str. 25, D-53127 Bonn

matthias.geyer@uni-bonn.de

+49 228 28751400

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The Geyer lab is interested in the regulation of transcription and the molecular mechanisms that govern immune receptor activation. We use a variety of techniques from molecular biology and biochemistry to structural biology to analyze interaction between proteins, RNA, lipids, and ligands. The transcription cycle is regulated by cyclin-dependent kinases that phosphorylate the RNA polymerase II. We analyze the transition from transcription initiation to productive elongation in eukaryotic cells. We study the molecular and structural mechanisms that determine the activity and regulation of transcription-controlling kinases, as well as their inhibition by small molecular compounds. We recently also focused on the analysis of receptor activation of NLRP3 and forma-tion of the NLRP3/ASC/caspase inflammasome. Besides NACHT-domain containing proteins, Toll-like receptors, RIG-I and the cGAS-STING pathway mediate the immune-recogni-tion of pathogens. We aim at identifying target sites in these immune regulators that allow for the specific interference with the immune system, e.g., by small molecular compounds.

Matthias Geyer

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Recent publications

  • Targeting CDKs in the RNAPII transcription cycle.

    Nature reviews. Drug discovery

    Authors: Robert P Fisher, Matthias Geyer

  • Molecular characterization of FAM222B as a novel disease gene for dominant cardiovascular laterality defects.

    Scientific reports

    Authors: Nina Reitz, Jessica Lambertz, Öznur Yilmaz, Tobias T Lindenberg, Khadija Channab, Birgit Rau, Stefanie Ramrath, Enrico Mingardo, Hanna Schöpper, Bettina C Kirchmaier, Matthias Geyer, Gabriel C Dworschak, Johannes Breuer, Nicole Müller, Birthe Schaidinger, Alina C Hilger, Julia Hoefele, Korbinian M Riedhammer, Marc-Phillip Hitz, Gregor Dombrowsky, Hashim Abdul-Khaliq, Ulrike M M Bauer, Lars Fester, Heiko M Reutter, Katinka Breuer, Benjamin Odermatt

  • AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.

    Nature communications

    Authors: Bianca Broske, Benjamin A McEnroe, Sophie C Frechen, Tim N Kempchen, Caroline I Fandrey, Elisabeth Tan, Dominic Ferber, Michelle C R Yong, Marie Kleinert, Julia M Messmer, Peter Konopka, Alexander Hoch, Katja Blumenstock, Jan M P Tödtmann, Johannes Oldenburg, Heiko Rühl, Alexander Semaan, Marieta I Toma, Kristina Markova, Sebastian Kobold, Tim Rollenske, Matthias Geyer, Stephan Menzel, Tobias Bald, Jonathan L Schmid-Burgk, Gregor Hagelueken, Michael Hölzel

All publications by Prof. Dr. Matthias Geyer