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Publications

featured publications

  • AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.

    Nature communications

    Authors: Bianca Broske, Benjamin A McEnroe, Sophie C Frechen, Tim N Kempchen, Caroline I Fandrey, Elisabeth Tan, Dominic Ferber, Michelle C R Yong, Marie Kleinert, Julia M Messmer, Peter Konopka, Alexander Hoch, Katja Blumenstock, Jan M P Tödtmann, Johannes Oldenburg, Heiko Rühl, Alexander Semaan, Marieta I Toma, Kristina Markova, Sebastian Kobold, Tim Rollenske, Matthias Geyer, Stephan Menzel, Tobias Bald, Jonathan L Schmid-Burgk, Gregor Hagelueken, Michael Hölzel

  • Quantitative modelling of P-TEFb mediated CTD phosphorylation identifies local cooperativity.

    PLoS computational biology

    Authors: Aaron Callenbach, Domagoj Dorešić, Robert Düster, Vanessa Nakonecnij, Erika Dudkin, Matthias Geyer, Jan Hasenauer

  • Membrane-Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans-Golgi Network.

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    Authors: Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann-Kathrin Dobbelstein, Anna Klawonn, Rebecca C Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B Schromm, Günther Weindl

  • C-terminal lysine residues localise NLRP10 at lipid droplets and govern NLRP10 oligomer formation.

    EMBO reports

    Authors: Timo-Daniel Voss, Christoph Winterberg, Adrian Beck, Clarissa Gottschild, Leonie Mueller, Selina M Enayat, Matthias Geyer, Thomas A Kufer

  • Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

    Human molecular genetics

    Authors: Julia A Capecki, Helena Shkuro, Öznur Yilmaz, Lisa Schmitt, Khadija Channab, Tobias T Lindenberg, Teresa Kruse, Sarah Achterrath, Berta Crespo, Anna Siewert, Mostafa Bakhshi, Leandra Pantel, Kerstin U Ludwig, Matthias Geyer, Elisabeth Mangold, Benjamin Odermatt, Nina Ishorst

  • Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation.

    Nature communications

    Authors: María Mateo-Tórtola, Inga V Hochheiser, Gaopeng Li, Lukas Funk, Atousa Hashemi, Xiao Liu, Jane Torp, Lena Erlebach, András Szolek, Jelena Grga, Francesca Bork, Jana S Müller, Deborah Kronenberg-Versteeg, Matthias Geyer, Alexander N R Weber, Ana Tapia-Abellán

  • Structure-Activity and Structure-Degradation Relationship Studies of 2-Amino-6-(benzimidazol-2-ylmethyl)-N9-heteroarylpurines as Potent and Selective CDK12/13 Inhibitors and Cyclin K Degraders.

    Journal of medicinal chemistry

    Authors: Thiyagamurthy Pandurangan, Solomon Tadesse Zeleke, Anna Iermolaieva, Pompom Ghosh, John Mosior, Luxin Sun, Dylan Grassie, Maximilian Schmitz, Mahalakshmi Naidu Kalaga, William Albritton, Manuel Manzanares Rodas, Sean Chin Chan, Sylvia Frydman, Samer Sansil, Matthias Geyer, Ernst Schönbrunn, William R Roush, Derek R Duckett, Andrii Monastyrskyi

  • Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor.

    Nature communications

    Authors: Jessica Nagel, Vigneshwaran Namasivayam, Stephanie Weinhausen, Juan Sierra-Marquez, Younis Baqi, Hashem Ali M Al Musawi, Aliaa Abdelrahman, Victoria J Vaaßen, Jonathan G Schlegel, Lisa Taplick, Jane Torp, Jan Kubicek, Barbara Maertens, Matthias Geyer, Tobias Claff, Annette Nicke, Gregor Hagelueken, Christa E Müller

  • Targeted Histone Deacetylase Degradation via Chemical Induced Proximity by Direct Recruitment of the CUL4 Complex Adaptor Protein DDB1.

    ACS medicinal chemistry letters

    Authors: Shiyang Zhai, Nicola Willemsen, Tao Sun, Mateo Malenica, Shixin Deng, Matthias Geyer, Finn K Hansen

  • Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.

    The Journal of experimental medicine

    Authors: Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, Mary Cochran, Samantha Cowdin, Kristen Fortney, George Hartman, Robert E Hughes, Rusty Montgomery, Claudia P Portillo, Paul Rubin, Taiz Salazar, Yan Wang, Shijun Yan, Barry A Morgan, Assem Duisembekova, Romane Riou, Michael Marleaux, Inga V Hochheiser, Hannes Buthmann, Dominic Ferber, Jane Torp, Wei Wang, Melanie Cranston, Chloe M McKee, Thea J Mawhinney, Emma C McKay, Fehime K Eroglu, Jasmin Kümmerle-Deschner, Alexander N R Weber, Bénédicte F Py, Matthias Geyer, Rebecca C Coll