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  • Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation.

    Nature communications

    Authors: María Mateo-Tórtola, Inga V Hochheiser, Gaopeng Li, Lukas Funk, Atousa Hashemi, Xiao Liu, Jane Torp, Lena Erlebach, András Szolek, Jelena Grga, Francesca Bork, Jana S Müller, Deborah Kronenberg-Versteeg, Matthias Geyer, Alexander N R Weber, Ana Tapia-Abellán

  • Structure-Activity and Structure-Degradation Relationship Studies of 2-Amino-6-(benzimidazol-2-ylmethyl)-N9-heteroarylpurines as Potent and Selective CDK12/13 Inhibitors and Cyclin K Degraders.

    Journal of medicinal chemistry

    Authors: Thiyagamurthy Pandurangan, Solomon Tadesse Zeleke, Anna Iermolaieva, Pompom Ghosh, John Mosior, Luxin Sun, Dylan Grassie, Maximilian Schmitz, Mahalakshmi Naidu Kalaga, William Albritton, Manuel Manzanares Rodas, Sean Chin Chan, Sylvia Frydman, Samer Sansil, Matthias Geyer, Ernst Schönbrunn, William R Roush, Derek R Duckett, Andrii Monastyrskyi

  • Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor.

    Nature communications

    Authors: Jessica Nagel, Vigneshwaran Namasivayam, Stephanie Weinhausen, Juan Sierra-Marquez, Younis Baqi, Hashem Ali M Al Musawi, Aliaa Abdelrahman, Victoria J Vaaßen, Jonathan G Schlegel, Lisa Taplick, Jane Torp, Jan Kubicek, Barbara Maertens, Matthias Geyer, Tobias Claff, Annette Nicke, Gregor Hagelueken, Christa E Müller

  • Targeted Histone Deacetylase Degradation via Chemical Induced Proximity by Direct Recruitment of the CUL4 Complex Adaptor Protein DDB1.

    ACS medicinal chemistry letters

    Authors: Shiyang Zhai, Nicola Willemsen, Tao Sun, Mateo Malenica, Shixin Deng, Matthias Geyer, Finn K Hansen

  • Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.

    The Journal of experimental medicine

    Authors: Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, Mary Cochran, Samantha Cowdin, Kristen Fortney, George Hartman, Robert E Hughes, Rusty Montgomery, Claudia P Portillo, Paul Rubin, Taiz Salazar, Yan Wang, Shijun Yan, Barry A Morgan, Assem Duisembekova, Romane Riou, Michael Marleaux, Inga V Hochheiser, Hannes Buthmann, Dominic Ferber, Jane Torp, Wei Wang, Melanie Cranston, Chloe M McKee, Thea J Mawhinney, Emma C McKay, Fehime K Eroglu, Jasmin Kümmerle-Deschner, Alexander N R Weber, Bénédicte F Py, Matthias Geyer, Rebecca C Coll

  • A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation.

    Molecular cell

    Authors: Jennifer R Devlin, Ben Martin, Nenad Bartonicek, Keziah Ting, Zheng Fan, Izabela Todorovski, Filip Bjelosevic, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Attila Horvath, Emily Tinsley, Peter Fraser, Andrea Newbold, Jarrod J Sandow, Andrea Muscat, Kaylene J Simpson, Matthias Geyer, Stephin J Vervoort, Ricky W Johnstone

  • The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets.

    Nature immunology

    Authors: Alexander N R Weber, Róisín M McManus, Veit Hornung, Matthias Geyer, Jasmin B Kuemmerle-Deschner, Eicke Latz

  • Haploinsufficiency of is associated with dominant isolated omphalocele.

    Frontiers in cell and developmental biology

    Authors: Caroline M Kolvenbach, Öznur Yilmaz, Filipa M Lopes, Jeshurun C Kalanithy, Katharina Lemberg, Vineeta Sharma, Amar J Majmundar, Matthias Geyer, Adrian S Woolf, Friedhelm Hildebrandt, Benjamin Odermatt, Heiko Reutter

  • Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants.

    Nature immunology

    Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters

  • Degrading the key component of the inflammasome: development of an NLRP3 PROTAC.

    Chemical communications (Cambridge, England)

    Authors: Tim Keuler, Dominic Ferber, Jonas Engelhardt, Christian Steinebach, Nico Kirsch, Michael Marleaux, Günther Weindl, Matthias Geyer, Michael Gütschow