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featured publications

  • RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.

    The EMBO journal

    Authors: Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

  • Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models.

    European journal of human genetics : EJHG

    Authors: Nina Ishorst, Selina Hölzel, Carola Greve, Öznur Yilmaz, Tobias Lindenberg, Jessica Lambertz, Dmitriy Drichel, Berina Zametica, Enrico Mingardo, Jeshurun C Kalanithy, Khadija Channab, Duygu Kibris, Sabrina Henne, Franziska Degenhardt, Anna Siewert, Michael Dixon, Teresa Kruse, Edwin Ongkosuwito, Katta M Girisha, Shruti Pande, Stefanie Nowak, Gregor Hagelueken, Matthias Geyer, Carine Carels, Iris A L M van Rooij, Kerstin U Ludwig, Benjamin Odermatt, Elisabeth Mangold

  • Cryo-EM structure of the human native plasma coagulation factor XIII complex.

    Blood

    Authors: Sneha Singh, Gregor Hagelueken, Deniz Ugurlar, Samhitha Urs Ramaraje Urs, Amit Sharma, Manoranjan Mahapatra, Friedel Drepper, Diana Imhof, Pitter F Huesgen, Johannes Oldenburg, Matthias Geyer, Arijit Biswas

  • Discovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K.

    RSC chemical biology

    Authors: Pompom Ghosh, Maximilian Schmitz, Thiyagamurthy Pandurangan, Solomon Tadesse Zeleke, Sean Chin Chan, John Mosior, Luxin Sun, Vinayak Palve, Dylan Grassie, Kanchan Anand, Sylvia Frydman, William R Roush, Ernst Schönbrunn, Matthias Geyer, Derek Duckett, Andrii Monastyrskyi

  • Insights into reproduction-regulating NOD-like receptors.

    Nature structural & molecular biology

    Authors: Inga V Hochheiser, Matthias Geyer

  • Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

    Nature communications

    Authors: Lisa D J Schiffelers, Yonas M Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L Ploegh, Florian I Schmidt

  • The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease.

    Nucleic acids research

    Authors: Sophie C Binder, Niels Schneberger, Maximilian Schmitz, Marianne Engeser, Matthias Geyer, Christophe Rouillon, Gregor Hagelueken

  • Structural basis of Cdk7 activation by dual T-loop phosphorylation.

    Nature communications

    Authors: Robert Düster, Kanchan Anand, Sophie C Binder, Maximilian Schmitz, Karl Gatterdam, Robert P Fisher, Matthias Geyer

  • A nonsense variant in KRT31 is associated with autosomal-dominant monilethrix.

    The British journal of dermatology

    Authors: Xing Xiong, Nicole Cesarato, Yasmina Gossmann, Maria Wehner, Sheetal Kumar, Holger Thiele, Stephanie Demuth, Vinzenz Oji, Matthias Geyer, Henning Hamm, F Buket Basmanav, Regina C Betz

  • Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.

    The Journal of experimental medicine

    Authors: Camille Cosson, Romane Riou, Danish Patoli, Tingting Niu, Amaury Rey, Marine Groslambert, Charlotte De Rosny, Elodie Chatre, Omran Allatif, Thomas Henry, Fabienne Venet, Florian Milhavet, Guilaine Boursier, Alexandre Belot, Yvan Jamilloux, Etienne Merlin, Agnès Duquesne, Gilles Grateau, Léa Savey, Alexandre Thibault Jacques Maria, Anne Pagnier, Solène Poutrel, Olivier Lambotte, Coralie Mallebranche, Samuel Ardois, Olivier Richer, Irène Lemelle, Frédéric Rieux-Laucat, Brigitte Bader-Meunier, Zahir Amoura, Isabelle Melki, Laurence Cuisset, Isabelle Touitou, Matthias Geyer, Sophie Georgin-Lavialle, Bénédicte F Py