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  • Targeted Histone Deacetylase Degradation via Chemical Induced Proximity by Direct Recruitment of the CUL4 Complex Adaptor Protein DDB1.

    ACS medicinal chemistry letters

    Authors: Shiyang Zhai, Nicola Willemsen, Tao Sun, Mateo Malenica, Shixin Deng, Matthias Geyer, Finn K Hansen

  • Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.

    The Journal of experimental medicine

    Authors: Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, Mary Cochran, Samantha Cowdin, Kristen Fortney, George Hartman, Robert E Hughes, Rusty Montgomery, Claudia P Portillo, Paul Rubin, Taiz Salazar, Yan Wang, Shijun Yan, Barry A Morgan, Assem Duisembekova, Romane Riou, Michael Marleaux, Inga V Hochheiser, Hannes Buthmann, Dominic Ferber, Jane Torp, Wei Wang, Melanie Cranston, Chloe M McKee, Thea J Mawhinney, Emma C McKay, Fehime K Eroglu, Jasmin Kümmerle-Deschner, Alexander N R Weber, Bénédicte F Py, Matthias Geyer, Rebecca C Coll

  • A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation.

    Molecular cell

    Authors: Jennifer R Devlin, Ben Martin, Nenad Bartonicek, Keziah Ting, Zheng Fan, Izabela Todorovski, Filip Bjelosevic, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Attila Horvath, Emily Tinsley, Peter Fraser, Andrea Newbold, Jarrod J Sandow, Andrea Muscat, Kaylene J Simpson, Matthias Geyer, Stephin J Vervoort, Ricky W Johnstone

  • The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets.

    Nature immunology

    Authors: Alexander N R Weber, Róisín M McManus, Veit Hornung, Matthias Geyer, Jasmin B Kuemmerle-Deschner, Eicke Latz

  • Haploinsufficiency of is associated with dominant isolated omphalocele.

    Frontiers in cell and developmental biology

    Authors: Caroline M Kolvenbach, Öznur Yilmaz, Filipa M Lopes, Jeshurun C Kalanithy, Katharina Lemberg, Vineeta Sharma, Amar J Majmundar, Matthias Geyer, Adrian S Woolf, Friedhelm Hildebrandt, Benjamin Odermatt, Heiko Reutter

  • Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants.

    Nature immunology

    Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters

  • Degrading the key component of the inflammasome: development of an NLRP3 PROTAC.

    Chemical communications (Cambridge, England)

    Authors: Tim Keuler, Dominic Ferber, Jonas Engelhardt, Christian Steinebach, Nico Kirsch, Michael Marleaux, Günther Weindl, Matthias Geyer, Michael Gütschow

  • RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I.

    The EMBO journal

    Authors: Alexander Kirchhoff, Anna-Maria Herzner, Christian Urban, Antonio Piras, Robert Düster, Julia Mahlberg, Agathe Grünewald, Thais M Schlee-Guimarães, Katrin Ciupka, Petro Leka, Robert J Bootz, Christina Wallerath, Charlotte Hunkler, Ann Kristin de Regt, Beate M Kümmerer, Maria Hønholt Christensen, Florian I Schmidt, Min Ae Lee-Kirsch, Claudia Günther, Hiroki Kato, Eva Bartok, Gunther Hartmann, Matthias Geyer, Andreas Pichlmair, Martin Schlee

  • Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models.

    European journal of human genetics : EJHG

    Authors: Nina Ishorst, Selina Hölzel, Carola Greve, Öznur Yilmaz, Tobias Lindenberg, Jessica Lambertz, Dmitriy Drichel, Berina Zametica, Enrico Mingardo, Jeshurun C Kalanithy, Khadija Channab, Duygu Kibris, Sabrina Henne, Franziska Degenhardt, Anna Siewert, Michael Dixon, Teresa Kruse, Edwin Ongkosuwito, Katta M Girisha, Shruti Pande, Stefanie Nowak, Gregor Hagelueken, Matthias Geyer, Carine Carels, Iris A L M van Rooij, Kerstin U Ludwig, Benjamin Odermatt, Elisabeth Mangold

  • Cryo-EM structure of the human native plasma coagulation factor XIII complex.

    Blood

    Authors: Sneha Singh, Gregor Hagelueken, Deniz Ugurlar, Samhitha Urs Ramaraje Urs, Amit Sharma, Manoranjan Mahapatra, Friedel Drepper, Diana Imhof, Pitter F Huesgen, Johannes Oldenburg, Matthias Geyer, Arijit Biswas