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featured publications

  • Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures.

    Antioxidants (Basel, Switzerland)

    Authors: Constanze Erdmann, Roua Hassoun, Sebastian Schmitt, Carlos Kikuti, Anne Houdusse, Antonina J Mazur, Andreas Mügge, Nazha Hamdani, Matthias Geyer, Kornelia Jaquet, Hans Georg Mannherz

  • Top publication

    LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.

    Nature biotechnology

    Authors: Kerstin U Ludwig, Ricarda M Schmithausen, David Li, Max L Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M Hochfeld, Eva C Beins, Ines H Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Eva-Maria C Moench, Jacob D Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus M Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L Schmid-Burgk

  • Development of Fluorescent and Biotin Probes Targeting NLRP3.

    Frontiers in chemistry

    Authors: Tim Keuler, Karl Gatterdam, Anil Akbal, Marta Lovotti, Michael Marleaux, Matthias Geyer, Eicke Latz, Michael Gütschow

  • Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.

    European journal of medicinal chemistry

    Authors: Baishan Jiang, Jie Jiang, Ines H Kaltheuner, Amanda Balboni Iniguez, Kanchan Anand, Fleur M Ferguson, Scott B Ficarro, Bo Kyung Alex Seong, Ann Katrin Greifenberg, Sofia Dust, Nicholas P Kwiatkowski, Jarrod A Marto, Kimberly Stegmaier, Tinghu Zhang, Matthias Geyer, Nathanael S Gray

  • Discovery and resistance mechanism of a selective CDK12 degrader.

    Nature chemical biology

    Authors: Baishan Jiang, Yang Gao, Jianwei Che, Wenchao Lu, Ines H Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M Riching, Danette L Daniels, Peter K Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S Gray

  • Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling.

    Nature chemical biology

    Authors: Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C Müller, Johannes Zuber, Matthias Geyer, Nicolas H Thomä, Stefan Kubicek, Georg E Winter

  • Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

    Science (New York, N.Y.)

    Authors: Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M Kümmerer, Florian N Gohr, Lea-Marie Jenster, Lisa D J Schiffelers, Yonas M Tesfamariam, Miki Uchima, Jennifer D Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H Christensen, Caroline I Fandrey, Sabine Normann, Jan M P Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A Wilson, Matthias Geyer, Kerstin U Ludwig, B Martin Hällberg, Nicholas C Wu, Florian I Schmidt

  • 1,6-Hexanediol, commonly used to dissolve liquid-liquid phase separated condensates, directly impairs kinase and phosphatase activities.

    The Journal of biological chemistry

    Authors: Robert Düster, Ines H Kaltheuner, Maximilian Schmitz, Matthias Geyer

  • NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity.

    The Journal of allergy and clinical immunology

    Authors: Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, Marquitta J White, Cassandra R Harapas, Chien-Hsiung Yu, Sophia Davidson, Katja Hrovat-Schaale, Donglei Hu, Celeste Eng, Scott Huntsman, Dale J Calleja, Jay C Horvat, Phil M Hansbro, Robert J J O'Donoghue, Jenny P Ting, Esteban G Burchard, Matthias Geyer, Motti Gerlic, Seth L Masters

  • Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.

    Genes & development

    Authors: Jenna K Rimel, Zachary C Poss, Benjamin Erickson, Zachary L Maas, Christopher C Ebmeier, Jared L Johnson, Tim-Michael Decker, Tomer M Yaron, Michael J Bradley, Kristin B Hamman, Shanhu Hu, Goran Malojcic, Jason J Marineau, Peter W White, Martine Brault, Limei Tao, Patrick DeRoy, Christian Clavette, Shraddha Nayak, Leah J Damon, Ines H Kaltheuner, Heeyoun Bunch, Lewis C Cantley, Matthias Geyer, Janet Iwasa, Robin D Dowell, David L Bentley, William M Old, Dylan J Taatjes