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  • Top publication

    Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.

    Nature communications

    Authors: Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D J Schiffelers, Florian I Schmidt, Matthias Geyer

  • The reversible inhibitor SR-4835 binds Cdk12/Cyclin K in a non-canonical G-loop conformation.

    The Journal of biological chemistry

    Authors: Maximilian Schmitz, Ines H Kaltheuner, Kanchan Anand, Robert Düster, Jonas Moecking, Andrii Monastyrskyi, Derek R Duckett, William R Roush, Matthias Geyer

  • Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2.

    Immunology

    Authors: Marie-T Hopp, Janine Holze, Felicitas Lauber, Laura Holtkamp, Dhruv C Rathod, Maria A Miteva, Elisa B Prestes, Matthias Geyer, Bénédicte Manoury, Nicolas S Merle, Lubka T Roumenina, Marcelo T Bozza, Günther Weindl, Diana Imhof

  • Top publication

    A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.

    Nucleic acids research

    Authors: Ann Kristin de Regt, Kanchan Anand, Katrin Ciupka, Felix Bender, Karl Gatterdam, Bastian Putschli, David Fusshöller, Daniel Hilbig, Alexander Kirchhoff, Charlotte Hunkler, Steven Wolter, Agathe Grünewald, Christina Wallerath, Christine Schuberth-Wagner, Janos Ludwig, Katrin Paeschke, Eva Bartok, Gregor Hagelueken, Gunther Hartmann, Thomas Zillinger, Matthias Geyer, Martin Schlee

  • Short anagen hair syndrome: Association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss.

    The British journal of dermatology

    Authors: Nicole Cesarato, Agnes Schwieger-Briel, Yasmina Gossmann, Sabrina K Henne, Kathrin Hillmann, Leonie H Frommherz, Maria Wehner, Xing Xiong, Holger Thiele, Vinzenz Oji, Donatella Milani, Iliana Tantcheva-Poor, Kathrin Giehl, Regina Fölster-Holst, Anne Teichler, Delphine Braeckmans, Peter H Hoeger, Gabriela Jones, Jorge Frank, Lisa Weibel, Ulrike Blume-Peytavi, Henning Hamm, Markus M Nöthen, Matthias Geyer, Stefanie Heilmann-Heimbach, F Buket Basmanav, Regina C Betz

  • Adenylation Domain-Guided Recruitment of Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis.

    ACS chemical biology

    Authors: Daniel A Wirtz, Niels Schneberger, Sophie Klöppel, René Richarz, Matthias Geyer, Gabriele M König, Gregor Hagelueken, Max Crüsemann

  • Oncogenic mutations impede nuclear RNA surveillance.

    Science (New York, N.Y.)

    Authors: Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Constance Wu, Kevin Y Chen, David Liu, Stanislav Bellaousov, Anna M Cox, Benjamin J E Martin, Tongwu Zhang, Calvin G Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E Esgdaille, Telmo Henriques, Kevin M Brown, Stephen J Chanock, Matthias Geyer, Karen Adelman, Phillip A Sharp, Richard A Young, Paul L Boutz, Leonard I Zon

  • Top publication

    Antiviral signalling by a cyclic nucleotide activated CRISPR protease.

    Nature

    Authors: Christophe Rouillon, Niels Schneberger, Haotian Chi, Katja Blumenstock, Stefano Da Vela, Katrin Ackermann, Jonas Moecking, Martin F Peter, Wolfgang Boenigk, Reinhard Seifert, Bela E Bode, Jonathan L Schmid-Burgk, Dmitri Svergun, Matthias Geyer, Malcolm F White, Gregor Hagelueken

  • ATP-binding and hydrolysis of human NLRP3.

    Communications biology

    Authors: Rebecca Brinkschulte, David M Fußhöller, Florian Hoss, Juan F Rodríguez-Alcázar, Mario A Lauterbach, Carl-Christian Kolbe, Melanie Rauen, Semra Ince, Christian Herrmann, Eicke Latz, Matthias Geyer

  • Top publication

    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.

    The Journal of experimental medicine

    Authors: Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D Wuerth, Lisa D J Schiffelers, Yonas M Tesfamariam, Florian N Gohr, Laura Klein, Ines H Kaltheuner, Stefan Ebner, Dorothee J Lapp, Jacob Mayer, Jonas Moecking, Hidde L Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M Kümmerer, Florian I Schmidt