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featured publications

  • Bi-allelic variants in CELSR3 are implicated in central nervous system and urinary tract anomalies.

    NPJ genomic medicine

    Authors: Jil D Stegmann, Jeshurun C Kalanithy, Gabriel C Dworschak, Nina Ishorst, Enrico Mingardo, Filipa M Lopes, Yee Mang Ho, Phillip Grote, Tobias T Lindenberg, Öznur Yilmaz, Khadija Channab, Steve Seltzsam, Shirlee Shril, Friedhelm Hildebrandt, Felix Boschann, André Heinen, Angad Jolly, Katherine Myers, Kim McBride, Mir Reza Bekheirnia, Nasim Bekheirnia, Marcello Scala, Manuela Morleo, Vincenzo Nigro, Annalaura Torella, Michele Pinelli, Valeria Capra, Andrea Accogli, Silvia Maitz, Alice Spano, Rory J Olson, Eric W Klee, Brendan C Lanpher, Se Song Jang, Jong-Hee Chae, Philipp Steinbauer, Dietmar Rieder, Andreas R Janecke, Julia Vodopiutz, Ida Vogel, Jenny Blechingberg, Jennifer L Cohen, Kacie Riley, Victoria Klee, Laurence E Walsh, Matthias Begemann, Miriam Elbracht, Thomas Eggermann, Arzu Stoppe, Kyra Stuurman, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Maureen S Mulhern, Tristan T Sands, Cheryl Cytrynbaum, Rosanna Weksberg, Federica Isidori, Tommaso Pippucci, Giulia Severi, Francesca Montanari, Michael C Kruer, Somayeh Bakhtiari, Hossein Darvish, Heiko Reutter, Gregor Hagelueken, Matthias Geyer, Adrian S Woolf, Jennifer E Posey, James R Lupski, Benjamin Odermatt, Alina C Hilger

  • The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening.

    Bioorganic & medicinal chemistry letters

    Authors: George Hartman, Paul Humphries, Robert Hughes, Andrew Ho, Rusty Montgomery, Aditi Deshpande, Maitriyee Mahanta, Sarah Tronnes, Samantha Cowdin, Xu He, Fangchao Liu, Lifang Zhang, Chuan Liu, Dengfeng Dou, Jin Li, Aleksander Spasic, Rebecca Coll, Michael Marleaux, Inga V Hochheiser, Matthias Geyer, Paul Rubin, Kristen Fortney, Kevin Wilhelmsen

  • Structural basis of Cdk7 activation by dual T-loop phosphorylation.

    bioRxiv : the preprint server for biology

    Authors: Robert Düster, Kanchan Anand, Sophie C Binder, Maximilian Schmitz, Karl Gatterdam, Robert P Fisher, Matthias Geyer

  • Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb.

    The Journal of biological chemistry

    Authors: Salla Kyheröinen, Bina Prajapati, Maria Sokolova, Maximilian Schmitz, Tiina Viita, Matthias Geyer, Maria K Vartiainen

  • Adipocyte precursor-derived NRG1 promotes resistance to FGFR inhibition in urothelial carcinoma.

    Cancer research

    Authors: Sana Hosni, Viola Kilian, Niklas Klümper, Daniela Gabbia, Katharina Sieckmann, Dillon Corvino, Anja Winkler, Miriam Saponaro, Karin Woersdoerfer, Doris Schmidt, Oliver Hahn, Ilaria Zanotto, Marina Bertlich, Marieta Toma, Tobias Bald, Markus Eckstein, Michael Hölzel, Matthias Geyer, Manuel Ritter, Dagmar Wachten, Sara De Martin, Abdullah Alajati

  • Top publication

    Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.

    Nature communications

    Authors: Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D J Schiffelers, Florian I Schmidt, Matthias Geyer

  • The reversible inhibitor SR-4835 binds Cdk12/Cyclin K in a non-canonical G-loop conformation.

    The Journal of biological chemistry

    Authors: Maximilian Schmitz, Ines H Kaltheuner, Kanchan Anand, Robert Düster, Jonas Moecking, Andrii Monastyrskyi, Derek R Duckett, William R Roush, Matthias Geyer

  • Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2.

    Immunology

    Authors: Marie-T Hopp, Janine Holze, Felicitas Lauber, Laura Holtkamp, Dhruv C Rathod, Maria A Miteva, Elisa B Prestes, Matthias Geyer, Bénédicte Manoury, Nicolas S Merle, Lubka T Roumenina, Marcelo T Bozza, Günther Weindl, Diana Imhof

  • Top publication

    A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.

    Nucleic acids research

    Authors: Ann Kristin de Regt, Kanchan Anand, Katrin Ciupka, Felix Bender, Karl Gatterdam, Bastian Putschli, David Fusshöller, Daniel Hilbig, Alexander Kirchhoff, Charlotte Hunkler, Steven Wolter, Agathe Grünewald, Christina Wallerath, Christine Schuberth-Wagner, Janos Ludwig, Katrin Paeschke, Eva Bartok, Gregor Hagelueken, Gunther Hartmann, Thomas Zillinger, Matthias Geyer, Martin Schlee

  • Short anagen hair syndrome: Association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss.

    The British journal of dermatology

    Authors: Nicole Cesarato, Agnes Schwieger-Briel, Yasmina Gossmann, Sabrina K Henne, Kathrin Hillmann, Leonie H Frommherz, Maria Wehner, Xing Xiong, Holger Thiele, Vinzenz Oji, Donatella Milani, Iliana Tantcheva-Poor, Kathrin Giehl, Regina Fölster-Holst, Anne Teichler, Delphine Braeckmans, Peter H Hoeger, Gabriela Jones, Jorge Frank, Lisa Weibel, Ulrike Blume-Peytavi, Henning Hamm, Markus M Nöthen, Matthias Geyer, Stefanie Heilmann-Heimbach, F Buket Basmanav, Regina C Betz