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featured publications

  • Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.

    FEBS letters

    Authors: Michael Marleaux, Kanchan Anand, Eicke Latz, Matthias Geyer

  • CDK13 cooperates with CDK12 to control global RNA polymerase II processivity.

    Science advances

    Authors: Zheng Fan, Jennifer R Devlin, Simon J Hogg, Maria A Doyle, Paul F Harrison, Izabela Todorovski, Leonie A Cluse, Deborah A Knight, Jarrod J Sandow, Gareth Gregory, Andrew Fox, Traude H Beilharz, Nicholas Kwiatkowski, Nichollas E Scott, Ana Tufegdzic Vidakovic, Gavin P Kelly, Jesper Q Svejstrup, Matthias Geyer, Nathanael S Gray, Stephin J Vervoort, Ricky W Johnstone

  • β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.

    Cell reports

    Authors: Lea L Friker, Hannah Scheiblich, Inga V Hochheiser, Rebecca Brinkschulte, Dietmar Riedel, Eicke Latz, Matthias Geyer, Michael T Heneka

  • Top publication

    The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.

    Nucleic acids research

    Authors: Lucia A Torres-Fernández, Bettina Jux, Maximilian Bille, Yasmine Port, Karin Schneider, Matthias Geyer, Günter Mayer, Waldemar Kolanus

  • Alternative splicing regulates stochastic NLRP3 activity.

    Nature communications

    Authors: Florian Hoss, James L Mueller, Francisca Rojas Ringeling, Juan F Rodriguez-Alcazar, Rebecca Brinkschulte, Gerald Seifert, Rainer Stahl, Lori Broderick, Chris D Putnam, Richard D Kolodner, Stefan Canzar, Matthias Geyer, Hal M Hoffman, Eicke Latz

  • CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.

    Nature communications

    Authors: Malgorzata Krajewska, Ruben Dries, Andrew V Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L Greenleaf, Guo-Cheng Yuan, Nathanael S Gray, Richard A Young, Matthias Geyer, Scott A Gerber, Rani E George

  • The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain.

    Scientific reports

    Authors: Saskia S Grueb, Stefanie Muhs, Yannes Popp, Sebastian Schmitt, Matthias Geyer, Yuan-Na Lin, Sabine Windhorst

  • MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.

    Molecular cell

    Authors: Apoorva Baluapuri, Julia Hofstetter, Nevenka Dudvarski Stankovic, Theresa Endres, Pranjali Bhandare, Seychelle Monique Vos, Bikash Adhikari, Jessica Denise Schwarz, Ashwin Narain, Markus Vogt, Shuang-Yan Wang, Robert Düster, Lisa Anna Jung, Jens Thorsten Vanselow, Armin Wiegering, Matthias Geyer, Hans Michael Maric, Peter Gallant, Susanne Walz, Andreas Schlosser, Patrick Cramer, Martin Eilers, Elmar Wolf

  • Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.

    Cell chemical biology

    Authors: Calla M Olson, Yanke Liang, Alan Leggett, Woojun D Park, Lianbo Li, Caitlin E Mills, Selma Z Elsarrag, Scott B Ficarro, Tinghu Zhang, Robert Düster, Matthias Geyer, Taebo Sim, Jarrod A Marto, Peter K Sorger, Ken D Westover, Charles Y Lin, Nicholas Kwiatkowski, Nathanael S Gray

  • P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.

    Molecular cell

    Authors: Andrii Bugai, Alexandre J C Quaresma, Caroline C Friedel, Tina Lenasi, Robert Düster, Christopher R Sibley, Koh Fujinaga, Petra Kukanja, Thomas Hennig, Melanie Blasius, Matthias Geyer, Jernej Ule, Lars Dölken, Matjaž Barborič