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featured publications

  • Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.

    Genes & development

    Authors: Jenna K Rimel, Zachary C Poss, Benjamin Erickson, Zachary L Maas, Christopher C Ebmeier, Jared L Johnson, Tim-Michael Decker, Tomer M Yaron, Michael J Bradley, Kristin B Hamman, Shanhu Hu, Goran Malojcic, Jason J Marineau, Peter W White, Martine Brault, Limei Tao, Patrick DeRoy, Christian Clavette, Shraddha Nayak, Leah J Damon, Ines H Kaltheuner, Heeyoun Bunch, Lewis C Cantley, Matthias Geyer, Janet Iwasa, Robin D Dowell, David L Bentley, William M Old, Dylan J Taatjes

  • CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8 T Cells.

    Immunity

    Authors: Matthias Braun, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, Luize G Lima, Lizeth G Meza Guzman, Kunlun Li, Rui Li, Nazhifah Salim, Maria Villancanas Jorge, Sunyoung Ham, Gabrielle Kelly, Frank Vari, Ailin Lepletier, Ashwini Raghavendra, Sally Pearson, Jason Madore, Sebastien Jacquelin, Maike Effern, Brodie Quine, Lambros T Koufariotis, Mika Casey, Kyohei Nakamura, Eun Y Seo, Michael Hölzel, Matthias Geyer, Glen Kristiansen, Touraj Taheri, Elizabeth Ahern, Brett G M Hughes, James S Wilmott, Georgina V Long, Richard A Scolyer, Martin D Batstone, Jennifer Landsberg, Dimo Dietrich, Oltin T Pop, Lukas Flatz, William C Dougall, André Veillette, Sandra E Nicholson, Andreas Möller, Robert J Johnston, Ludovic Martinet, Mark J Smyth, Tobias Bald

  • Rational discovery of molecular glue degraders via scalable chemical profiling.

    Nature chemical biology

    Authors: Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C Müller, Johannes Zuber, Matthias Geyer, Nicolas H Thomä, Stefan Kubicek, Georg E Winter

  • Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.

    FEBS letters

    Authors: Michael Marleaux, Kanchan Anand, Eicke Latz, Matthias Geyer

  • CDK13 cooperates with CDK12 to control global RNA polymerase II processivity.

    Science advances

    Authors: Zheng Fan, Jennifer R Devlin, Simon J Hogg, Maria A Doyle, Paul F Harrison, Izabela Todorovski, Leonie A Cluse, Deborah A Knight, Jarrod J Sandow, Gareth Gregory, Andrew Fox, Traude H Beilharz, Nicholas Kwiatkowski, Nichollas E Scott, Ana Tufegdzic Vidakovic, Gavin P Kelly, Jesper Q Svejstrup, Matthias Geyer, Nathanael S Gray, Stephin J Vervoort, Ricky W Johnstone

  • β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.

    Cell reports

    Authors: Lea L Friker, Hannah Scheiblich, Inga V Hochheiser, Rebecca Brinkschulte, Dietmar Riedel, Eicke Latz, Matthias Geyer, Michael T Heneka

  • Top publication

    The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.

    Nucleic acids research

    Authors: Lucia A Torres-Fernández, Bettina Jux, Maximilian Bille, Yasmine Port, Karin Schneider, Matthias Geyer, Günter Mayer, Waldemar Kolanus

  • Alternative splicing regulates stochastic NLRP3 activity.

    Nature communications

    Authors: Florian Hoss, James L Mueller, Francisca Rojas Ringeling, Juan F Rodriguez-Alcazar, Rebecca Brinkschulte, Gerald Seifert, Rainer Stahl, Lori Broderick, Chris D Putnam, Richard D Kolodner, Stefan Canzar, Matthias Geyer, Hal M Hoffman, Eicke Latz

  • CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.

    Nature communications

    Authors: Malgorzata Krajewska, Ruben Dries, Andrew V Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L Greenleaf, Guo-Cheng Yuan, Nathanael S Gray, Richard A Young, Matthias Geyer, Scott A Gerber, Rani E George

  • The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain.

    Scientific reports

    Authors: Saskia S Grueb, Stefanie Muhs, Yannes Popp, Sebastian Schmitt, Matthias Geyer, Yuan-Na Lin, Sabine Windhorst