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Prof. Dr. med. Gunther Hartmann

Speaker, Member, Steering-Committee Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg - Campus 1 53127 Bonn

gunther.hartmann@ukbonn.de

+49 228 28716080

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For over 20 years, Prof Hartmann’s research focus has been nucleic acid sensing in the broader context of nucleic acid immunity, and he has made fundamental contributions to the identification, characterization and immunobiology of nucleic acid ligands of TLR7, TLR8, TLR9, RIG-I, STING and cGAS. His group has discovered a pivotal mechanism by which RIG-I discriminates between foreign and self RNA, which is highly relevant for the development of improved mRNA vaccines. He has characterized the role of NLRP3 in NK-cell memory, has contributed to the discovery of cyclic [G(2’,5’) pA(3’,5’)p] (cGAMP), the metazoan second messenger in the cGAS- STING pathway, and to the identification of Y-form DNA as a minimal ligand for cGAS, and has demonstrated that RIG-I-triggered innate antiviral immunity can be used for prophylaxis and for treatment of viral infections such as influenza and SARS-CoV-2 in vivo.

Gunther Hartmann

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Recent publications

  • Expression Analysis of let-7a-5p and miR-21-3p in Extracellular Vesicles Derived from Serum of NSCLC Patients.

    Biomedicines

    Authors: Dian Jamel Salih, Katrin S Reiners, Domenico Loizzi, Nicoletta Pia Ardò, Teresa Antonia Santantonio, Francesco Sollitto, Gunther Hartmann

  • Isolation and characterization of extracellular vesicles from EGFR mutated lung cancer cells.

    Clinical and experimental medicine

    Authors: Dian Jamel Salih, Katrin S Reiners, Roberta Alfieri, Ahmed Mohammed Salih, Zulema Antonia Percario, Mariantonietta Di Stefano, Sollitto Francesco, Elisabetta Affabris, Gunther Hartmann, Teresa Santantonio

  • Immunoengineering of a Photocaged 5´-triphosphate Oligoribonucleotide Ligand for Spatiotemporal Control of RIG-I Activation in Cancer.

    Angewandte Chemie (International ed. in English)

    Authors: Sandra Lewash, Vivien McKenney, Christine Wuebben, Janos Ludwig, Racha Hosni, Dirk Radzey, Marieta Toma, Martin Schlee, Eva Bartok, Thomas Zillinger, Alexander Heckel, Gunther Hartmann

All publications by Prof. Dr. med. Gunther Hartmann