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Prof. Dr. med. Gunther Hartmann

Speaker, Member, Steering-Committee Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg - Campus 1 53127 Bonn

+49 228 28716080


For over 20 years, Prof Hartmann’s research focus has been nucleic acid sensing in the broader context of nucleic acid immunity, and he has made fundamental contributions to the identification, characterization and immunobiology of nucleic acid ligands of TLR7, TLR8, TLR9, RIG-I, STING and cGAS. His group has discovered a pivotal mechanism by which RIG-I discriminates between foreign and self RNA, which is highly relevant for the development of improved mRNA vaccines. He has characterized the role of NLRP3 in NK-cell memory, has contributed to the discovery of cyclic [G(2’,5’) pA(3’,5’)p] (cGAMP), the metazoan second messenger in the cGAS- STING pathway, and to the identification of Y-form DNA as a minimal ligand for cGAS, and has demonstrated that RIG-I-triggered innate antiviral immunity can be used for prophylaxis and for treatment of viral infections such as influenza and SARS-CoV-2 in vivo.

Recent publications

  • Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy.

    Cell reports. Medicine

    Authors: Simon Heidegger, Florian Stritzke, Sarah Dahl, Juliane Daßler-Plenker, Laura Joachim, Dominik Buschmann, Kaiji Fan, Carolin M Sauer, Nils Ludwig, Christof Winter, Stefan Enssle, Suqi Li, Markus Perl, André Görgens, Tobias Haas, Erik Thiele Orberg, Sascha Göttert, Catherine Wölfel, Thomas Engleitner, Isidro Cortés-Ciriano, Roland Rad, Wolfgang Herr, Bernd Giebel, Jürgen Ruland, Florian Bassermann, Christoph Coch, Gunther Hartmann, Hendrik Poeck

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  • Dose Recommendations for Common Drugs in Patients with Liver Cirrhosis: A Systematic Literature Review.

    Clinical drug investigation

    Authors: Katharina Karsten Dafonte, Lisa Weber, Florian Chmielewski, Anna Maria Böhmer, Philipp Lutz, Gunther Hartmann, Ulrich Jaehde, Martin Coenen

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  • Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode .


    Authors: Johanna F Scheunemann, Frederic Risch, Julia J Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P Hübner

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