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Prof. Dr. med. Gunther Hartmann

Speaker, Member, Steering-Committee Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg - Campus 1 53127 Bonn

gunther.hartmann@ukbonn.de

+49 228 28716080

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For over 20 years, Prof Hartmann’s research focus has been nucleic acid sensing in the broader context of nucleic acid immunity, and he has made fundamental contributions to the identification, characterization and immunobiology of nucleic acid ligands of TLR7, TLR8, TLR9, RIG-I, STING and cGAS. His group has discovered a pivotal mechanism by which RIG-I discriminates between foreign and self RNA, which is highly relevant for the development of improved mRNA vaccines. He has characterized the role of NLRP3 in NK-cell memory, has contributed to the discovery of cyclic [G(2’,5’) pA(3’,5’)p] (cGAMP), the metazoan second messenger in the cGAS- STING pathway, and to the identification of Y-form DNA as a minimal ligand for cGAS, and has demonstrated that RIG-I-triggered innate antiviral immunity can be used for prophylaxis and for treatment of viral infections such as influenza and SARS-CoV-2 in vivo.

Gunther Hartmann

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Recent publications

  • Investigating the contextual modulation of postoperative gastrointestinal motility: a methodological feasibility study combining a standardized intervention protocol with wireless motility capsule monitoring.

    Frontiers in psychology

    Authors: Martin Coenen, Manfred Schedlowski, Gunther Hartmann, Jörg C Kalff, Thomas Büttner, Tim O Vilz

  • A novel provocation protocol to identify nocebo effects in clinical practice-a proof-of-concept n-of-1 study.

    Frontiers in pharmacology

    Authors: Martin Coenen, Gunther Hartmann, Thomas Büttner

  • Dose Recommendations for Drugs in Patients With Liver Cirrhosis (The ALIVe Study): Protocol for a Multiphase Validation and Consensus Study.

    JMIR research protocols

    Authors: Katharina Karsten Dafonte, Philipp Lutz, Christian Jansen, Christian P Strassburg, Robert Németh, Gunther Hartmann, Ulrich Jaehde, Martin Coenen

All publications by Prof. Dr. med. Gunther Hartmann