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featured publications

  • Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP kinase inhibition against BRAF-mutated melanoma.

    Molecular therapy. Nucleic acids

    Authors: Christian Grützner, Yu Pan Tan, Patrick Müller, Thais M Schlee-Guimaraes, Marius Jentzsch, Jonathan L Schmid-Burgk, Marcel Renn, Rayk Behrendt, Gunther Hartmann

  • Induction and antiviral activity of ferret myxovirus resistance (Mx) protein 1 against influenza A viruses.

    Scientific reports

    Authors: Rubaiyea Farrukee, Lara S U Schwab, James B Barnes, Andrew G Brooks, Sarah L Londrigan, Gunther Hartmann, Thomas Zillinger, Patrick C Reading

  • Top publication

    Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release.

    Nature communications

    Authors: Sarah Rösing, Fabian Ullrich, Susann Meisterfeld, Franziska Schmidt, Laura Mlitzko, Marijana Croon, Ryan G Nattrass, Nadia Eberl, Julia Mahlberg, Martin Schlee, Anja Wieland, Philipp Simon, Daniel Hilbig, Ulrike Reuner, Alexander Rapp, Julia Bremser, Peter Mirtschink, Stephan Drukewitz, Thomas Zillinger, Stefan Beissert, Katrin Paeschke, Gunther Hartmann, Aleksandra Trifunovic, Eva Bartok, Claudia Günther

  • Cooperative activation of human TLR9 and consequences for the clinical development of antisense and CpG oligodeoxynucleotides.

    Molecular therapy. Nucleic acids

    Authors: Gunther Hartmann

  • Top publication

    A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.

    Nucleic acids research

    Authors: Ann Kristin de Regt, Kanchan Anand, Katrin Ciupka, Felix Bender, Karl Gatterdam, Bastian Putschli, David Fusshöller, Daniel Hilbig, Alexander Kirchhoff, Charlotte Hunkler, Steven Wolter, Agathe Grünewald, Christina Wallerath, Christine Schuberth-Wagner, Janos Ludwig, Katrin Paeschke, Eva Bartok, Gregor Hagelueken, Gunther Hartmann, Thomas Zillinger, Matthias Geyer, Martin Schlee

  • Assessment of technical and clinical utility of a bead-based flow cytometry platform for multiparametric phenotyping of CNS-derived extracellular vesicles.

    Cell communication and signaling : CCS

    Authors: Alexandra Brahmer, Carsten Geiß, Andriani Lygeraki, Elmo Neuberger, Theophilos Tzaridis, Tinh Thi Nguyen, Felix Luessi, Anne Régnier-Vigouroux, Gunther Hartmann, Perikles Simon, Kristina Endres, Stefan Bittner, Katrin S Reiners, Eva-Maria Krämer-Albers

  • Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy.

    Cell reports. Medicine

    Authors: Simon Heidegger, Florian Stritzke, Sarah Dahl, Juliane Daßler-Plenker, Laura Joachim, Dominik Buschmann, Kaiji Fan, Carolin M Sauer, Nils Ludwig, Christof Winter, Stefan Enssle, Suqi Li, Markus Perl, André Görgens, Tobias Haas, Erik Thiele Orberg, Sascha Göttert, Catherine Wölfel, Thomas Engleitner, Isidro Cortés-Ciriano, Roland Rad, Wolfgang Herr, Bernd Giebel, Jürgen Ruland, Florian Bassermann, Christoph Coch, Gunther Hartmann, Hendrik Poeck

  • Dose Recommendations for Common Drugs in Patients with Liver Cirrhosis: A Systematic Literature Review.

    Clinical drug investigation

    Authors: Katharina Karsten Dafonte, Lisa Weber, Florian Chmielewski, Anna Maria Böhmer, Philipp Lutz, Gunther Hartmann, Ulrich Jaehde, Martin Coenen

  • Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode .

    Vaccines

    Authors: Johanna F Scheunemann, Frederic Risch, Julia J Reichwald, Benjamin Lenz, Anna-Lena Neumann, Stephan Garbe, Stefan J Frohberger, Marianne Koschel, Jesuthas Ajendra, Maximilian Rothe, Eicke Latz, Christoph Coch, Gunther Hartmann, Beatrix Schumak, Achim Hoerauf, Marc P Hübner

  • Quantitative protein biomarker panels: a path to improved clinical practice through proteomics.

    EMBO molecular medicine

    Authors: Johannes Hartl, Florian Kurth, Kai Kappert, David Horst, Michael Mülleder, Gunther Hartmann, Markus Ralser