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Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

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Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

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Recent publications

  • Melanoma Brain Metastases Patient-Derived Organoids: An In Vitro Platform for Drug Screening.

    Pharmaceutics

    Authors: Saif-Eldin Abedellatif, Racha Hosni, Andreas Waha, Gerrit H Gielen, Mohammed Banat, Motaz Hamed, Erdem Güresir, Anne Fröhlich, Judith Sirokay, Anna-Lena Wulf, Glen Kristiansen, Torsten Pietsch, Hartmut Vatter, Michael Hölzel, Matthias Schneider, Marieta Ioana Toma

  • Membranous expression of target protein is required for ADC response in urothelial cancer.

    European urology

    Authors: Niklas Klümper, Johannes Brägelmann, Veronika Bahlinger, Arndt Hartmann, Viktor Grünwald, Christoph Kuppe, Michael Hölzel, Markus Eckstein

  • Exploring membranous NECTIN-4 expression patterns and enfortumab vedotin response in prostate cancer.

    Journal of cellular and molecular medicine

    Authors: Richard Weiten, Marit Bernhardt, Max Niemann, Glen Kristiansen, Viktor Grünwald, Manuel Ritter, Michael Hölzel, Markus Eckstein, Abdullah Alajati, Niklas Klümper, Philipp Krausewitz

All publications by Prof. Dr. Michael Hölzel