Skip to main content

Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

Website

Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

Download biosketch

Recent publications

  • Integrating NECTIN4 Amplification With Membranous Nectin-4 Expression to Develop a Scoring System for Predicting Enfortumab Vedotin Response in Urothelial Carcinoma.

    Clinical cancer research : an official journal of the American Association for Cancer Research

    Authors: Niklas Klümper, Thomas Büttner, Sebastian Rauch, Stefanie Zschäbitz, Florian Roghmann, Christian Bolenz, Fabienne Lange, Patricia Rausch, Friedemann Zengerling, Nadine Gaisa, Oliver Hahn, Constantin Schwab, Anna Scherping, Marieta Toma, Hendrik Heers, Phillipp Ivanyi, Guenter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Pia Paffenholz, Richard Weiten, Susanne Füssel, Christian Thomas, Marcus Sondermann, Ulrich Sommer, Kerstin Junker, Katrin Schlack, Jozefina Casuscelli, Can Aydogdu, Dora Niedersüß-Beke, Steffen Rausch, Christoph Kuppe, Joshua Meeks, Bonnie Choy, Sarmad Sadeghi, Parkash Gill, Manuel Ritter, Johannes Brägelmann, Michael Hölzel, Arndt Hartmann, Viktor Grünwald, Jonas Saal, Markus Eckstein

  • AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.

    Nature communications

    Authors: Bianca Broske, Benjamin A McEnroe, Sophie C Frechen, Tim N Kempchen, Caroline I Fandrey, Elisabeth Tan, Dominic Ferber, Michelle C R Yong, Marie Kleinert, Julia M Messmer, Peter Konopka, Alexander Hoch, Katja Blumenstock, Jan M P Tödtmann, Johannes Oldenburg, Heiko Rühl, Alexander Semaan, Marieta I Toma, Kristina Markova, Sebastian Kobold, Tim Rollenske, Matthias Geyer, Stephan Menzel, Tobias Bald, Jonathan L Schmid-Burgk, Gregor Hagelueken, Michael Hölzel

  • Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.

    Nature protocols

    Authors: Ahmad Melhem, Barbara E F Pregler, Juan Eduardo Rodriguez-Gatica, Lea L Friker, Jake Thomas, Marieta I Toma, Mike-Andrew Westhoff, Vidhya M Ravi, Valeri Borger, Dieter Henrik Heiland, Julian P Layer, Andreas Schlitzer, Torsten Pietsch, Michael Hölzel, Andreas Waha, Hartmut Vatter, Martin K Schwarz, Ulrich Herrlinger, Ulrich Kubitscheck, Anna-Laura Potthoff, Matthias Schneider

All publications by Prof. Dr. Michael Hölzel