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Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

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Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

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Recent publications

  • L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.

    Nature communications

    Authors: Frank A Giordano, Julian P Layer, Roberta Turiello, Lea L Friker, Oriol Mirallas, Barbara E F Pregler, Anna-Laura Potthoff, Thomas Zeyen, Johannes Weller, Elena Sperk, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Niklas Schäfer, Sebastian Kadzik, Mirjam Renovanz, Torsten Pietsch, Sotirios Bisdas, Juan Manuel Sepúlveda-Sánchez, Diego Gómez-Puerto, Maria Vieito, Michael Platten, Eleni Gkika, Oliver M Grauer, Ghazaleh Tabatabai, Matthias Schneider, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel

  • Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment.

    Oncoimmunology

    Authors: Stefanie Höppner, Lisa Werr, Beata Szilagyi, Christoph Bartenhagen, Anna-Maria Hellmann, Carolina Rosswog, Emma Linden, Gerrit Primke, Yvonne Kahlert, Nadliv Ibruli, Nadine Hemstedt, Witali Lorenz, Johannes Brägelmann, Michael Hölzel, Matthias Fischer

  • Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone.

    Immunity

    Authors: Felix C Nebeling, Falko Fuhrmann, Manuel Mittag, Fabrizio Musacchio, Henrike Antony, Nala Gockel, Lea L Friker, Sonia Leonardelli, Severin Filser, Deli A, Miriam Stork, Daniele Bano, Torsten Pietsch, Frank A Giordano, Qihui Zhou, Simona Parrinello, Michael Hölzel, Ulrich Herrlinger, Paolo Salomoni, Martin Fuhrmann

All publications by Prof. Dr. Michael Hölzel