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Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

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Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

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Recent publications

  • SPACEc: a streamlined, interactive Python workflow for multiplexed image processing and analysis.

    Nature communications

    Authors: Yuqi Tan, Tim N Kempchen, Martin Becker, Maximilian Haist, Dorien Feyaerts, Jiaqi Liu, Marieta Toma, Yang Xiao, Graham Su, Andrew J Rech, Michael Hölzel, Rong Fan, John W Hickey, Garry P Nolan

  • Can NaCl predict or even enhance responses to immunotherapy in cancer?

    European journal of cancer (Oxford, England : 1990)

    Authors: Jonas Saal, Michael Hölzel, Niklas Klümper

  • Flow cytometry protocol for cell death analysis in glioblastoma organoids: A technical note.

    PloS one

    Authors: Anna-Laura Potthoff, Meng-Chun Hsieh, Ahmad Melhem, Susanna S Ng, Barbara E F Pregler, Annika Vieregge, Markus Raspe, Lea L Friker, Thomas Zeyen, Julian P Layer, Andreas Dolf, Marieta I Toma, Andreas Waha, Torsten Pietsch, Mike-Andrew Westhoff, Hartmut Vatter, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider

All publications by Prof. Dr. Michael Hölzel