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Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

+49 228 28751393


Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Recent publications

  • The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer.

    European urology

    Authors: Niklas Klümper, Viktor Grünwald, Arndt Hartmann, Michael Hölzel, Markus Eckstein

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  • High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma.

    European journal of cancer (Oxford, England : 1990)

    Authors: Niklas Klümper, Alexander Cox, Markus Eckstein, Christoph Kuppe, Manuel Ritter, Peter Brossart, Julian Luetkens, Michael Hölzel, Johannes Stein, Jonas Saal

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  • Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    Authors: Niklas Klümper, Ngoc Khanh Tran, Stefanie Zschäbitz, Oliver Hahn, Thomas Büttner, Florian Roghmann, Christian Bolenz, Friedemann Zengerling, Constantin Schwab, Dora Nagy, Marieta Toma, Glen Kristiansen, Hendrik Heers, Philipp Ivanyi, Günter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Arian Farid, Katrin Schlack, Mahmoud Abbas, Can Aydogdu, Jozefina Casuscelli, Theresa Mokry, Michael Mayr, Dora Niedersüß-Beke, Steffen Rausch, Dimo Dietrich, Jonas Saal, Jörg Ellinger, Manuel Ritter, Abdullah Alajati, Christoph Kuppe, Joshua Meeks, Francisco E Vera Badillo, J Alberto Nakauma-González, Joost Boormans, Kerstin Junker, Arndt Hartmann, Viktor Grünwald, Michael Hölzel, Markus Eckstein

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