Skip to main content

Prof. Dr. Michael Hölzel

Member, Steering-Committee Member

Institute of Experimental Oncology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

michael.hoelzel@ukbonn.de

+49 228 28751393

Website

Michael Hölzel has long-standing research expertise in the field of tumor biology and functional genomics with a particular focus on neural crest derived tumors such as melanoma. Currently his group investigates how the im-mune system crosstalks with the tumor cells in response to danger and proinflammatory signals released by therapy- induced tumor tissue injury. A central hypothesis is that this reciprocal communication drives therapy relapse due to rewiring of survival and differentiation pathways in tumor cells. This knowledge is critically needed for the rational combination of immunotherapies and targeted signal transduction inhibitors in the clinic.

Michael Hölzel

Download biosketch

Recent publications

  • Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell.

    Nature immunology

    Authors: Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel, Mark J Smyth

  • Integration of on-treatment modified Glasgow prognostic score (mGPS) to improve imaging-based prediction of outcomes in patients with non-small cell lung cancer on immune checkpoint inhibition.

    Lung cancer (Amsterdam, Netherlands)

    Authors: Jonas Saal, Tobias Bald, Markus Eckstein, Damian J Ralser, Peter Brossart, Jörg Ellinger, Michael Hölzel, Niklas Klümper

  • Top publication

    CD4 T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses.

    Science immunology

    Authors: Emma G Bawden, Teagan Wagner, Jan Schröder, Maike Effern, Daniel Hinze, Lewis Newland, Grace H Attrill, Ariane R Lee, Sven Engel, David Freestone, Marcela de Lima Moreira, Elise Gressier, Nathan McBain, Annabell Bachem, Ashraful Haque, Ruining Dong, Angela L Ferguson, Jarem J Edwards, Peter M Ferguson, Richard A Scolyer, James S Wilmott, Christopher M Jewell, Andrew G Brooks, David E Gyorki, Umaimainthan Palendira, Sammy Bedoui, Jason Waithman, Katharina Hochheiser, Michael Hölzel, Thomas Gebhardt

All publications by Prof. Dr. Michael Hölzel