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featured publications

  • Beyond Dose Escalation in Glioblastoma: Lessons Learned from INTRAGO-II and the Case for Targeting Tumor Biology.

    Neuro-oncology

    Authors: Julian Philipp Layer, Matthias Schneider, Michael Hölzel, Ulrich Herrlinger, Frank Winkler

  • Integrating NECTIN4 Amplification With Membranous Nectin-4 Expression to Develop a Scoring System for Predicting Enfortumab Vedotin Response in Urothelial Carcinoma.

    Clinical cancer research : an official journal of the American Association for Cancer Research

    Authors: Niklas Klümper, Thomas Büttner, Sebastian Rauch, Stefanie Zschäbitz, Florian Roghmann, Christian Bolenz, Fabienne Lange, Patricia Rausch, Friedemann Zengerling, Nadine Gaisa, Oliver Hahn, Constantin Schwab, Anna Scherping, Marieta Toma, Hendrik Heers, Phillipp Ivanyi, Guenter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Pia Paffenholz, Richard Weiten, Susanne Füssel, Christian Thomas, Marcus Sondermann, Ulrich Sommer, Kerstin Junker, Katrin Schlack, Jozefina Casuscelli, Can Aydogdu, Dora Niedersüß-Beke, Steffen Rausch, Christoph Kuppe, Joshua Meeks, Bonnie Choy, Sarmad Sadeghi, Parkash Gill, Manuel Ritter, Johannes Brägelmann, Michael Hölzel, Arndt Hartmann, Viktor Grünwald, Jonas Saal, Markus Eckstein

  • AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.

    Nature communications

    Authors: Bianca Broske, Benjamin A McEnroe, Sophie C Frechen, Tim N Kempchen, Caroline I Fandrey, Elisabeth Tan, Dominic Ferber, Michelle C R Yong, Marie Kleinert, Julia M Messmer, Peter Konopka, Alexander Hoch, Katja Blumenstock, Jan M P Tödtmann, Johannes Oldenburg, Heiko Rühl, Alexander Semaan, Marieta I Toma, Kristina Markova, Sebastian Kobold, Tim Rollenske, Matthias Geyer, Stephan Menzel, Tobias Bald, Jonathan L Schmid-Burgk, Gregor Hagelueken, Michael Hölzel

  • Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.

    Nature protocols

    Authors: Ahmad Melhem, Barbara E F Pregler, Juan Eduardo Rodriguez-Gatica, Lea L Friker, Jake Thomas, Marieta I Toma, Mike-Andrew Westhoff, Vidhya M Ravi, Valeri Borger, Dieter Henrik Heiland, Julian P Layer, Andreas Schlitzer, Torsten Pietsch, Michael Hölzel, Andreas Waha, Hartmut Vatter, Martin K Schwarz, Ulrich Herrlinger, Ulrich Kubitscheck, Anna-Laura Potthoff, Matthias Schneider

  • Longitudinal spatial neutrophil profiling during ACT in murine melanoma reveals distinct lymph node infiltration patterns.

    NPJ systems biology and applications

    Authors: Gemma van der Voort, Maike Effern, Michelle C R Yong, Lukas Kiwitz, Roberta Turiello, Sonia Leonardelli, Susanna Ng, Dillon Corvino, Tobias Bald, Nicole Glodde, Kevin Thurley, Jan Hasenauer, Michael Hölzel

  • L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.

    Nature communications

    Authors: Frank A Giordano, Julian P Layer, Roberta Turiello, Lea L Friker, Oriol Mirallas, Barbara E F Pregler, Anna-Laura Potthoff, Thomas Zeyen, Johannes Weller, Elena Sperk, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Niklas Schäfer, Sebastian Kadzik, Mirjam Renovanz, Torsten Pietsch, Sotirios Bisdas, Juan Manuel Sepúlveda-Sánchez, Diego Gómez-Puerto, Maria Vieito, Michael Platten, Eleni Gkika, Oliver M Grauer, Ghazaleh Tabatabai, Matthias Schneider, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel

  • Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment.

    Oncoimmunology

    Authors: Stefanie Höppner, Lisa Werr, Beata Szilagyi, Christoph Bartenhagen, Anna-Maria Hellmann, Carolina Rosswog, Emma Linden, Gerrit Primke, Yvonne Kahlert, Nadliv Ibruli, Nadine Hemstedt, Witali Lorenz, Johannes Brägelmann, Michael Hölzel, Matthias Fischer

  • Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone.

    Immunity

    Authors: Felix C Nebeling, Falko Fuhrmann, Manuel Mittag, Fabrizio Musacchio, Henrike Antony, Nala Gockel, Lea L Friker, Sonia Leonardelli, Severin Filser, Deli A, Miriam Stork, Daniele Bano, Torsten Pietsch, Frank A Giordano, Qihui Zhou, Simona Parrinello, Michael Hölzel, Ulrich Herrlinger, Paolo Salomoni, Martin Fuhrmann

  • Amplification Is a Frequent Event in Central Nervous System Metastases of Urothelial Carcinoma.

    European urology open science

    Authors: Richard Weiten, Constantin Rieger, Julian Heidenreich, Yuri Tolkach, Thomas Stehle, Florian Schmid, Teresa Schmidt, Martin Glas, Tobias Blau, Kathy Keyvani, Thomas Büttner, Viktor Grünwald, Michael Hölzel, Axel Heidenreich, Markus Eckstein, Niklas Klümper

  • High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma.

    Cell death & disease

    Authors: Clivia Lisowski, Natascha E Stumpf, Katarzyna Jobin, Daniela Klaus, Melanie Eichler, Ann-Kathrin Baumgart, Olena Babyak, Mirjam Meißner, Agnes Schröder, Patrick Neubert, Vanessa Schmitt, Marcel Michla, Süleyman Bozkurt, Jelena Zurkovic, Daniel Hinze, Jana Liebing, Matthias Eckhardt, Christoph Heuser, Lea Seep, Annkristin Heine, Janine Becker-Gotot, Christoph Thiele, Christian Münch, Thomas Becker, Jonathan Jantsch, Christoph Wilhelm, Michael Hölzel, Christian Kurts