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featured publications

  • Integration of on-treatment modified Glasgow prognostic score (mGPS) to improve imaging-based prediction of outcomes in patients with non-small cell lung cancer on immune checkpoint inhibition.

    Lung cancer (Amsterdam, Netherlands)

    Authors: Jonas Saal, Tobias Bald, Markus Eckstein, Damian J Ralser, Peter Brossart, Jörg Ellinger, Michael Hölzel, Niklas Klümper

  • CD4 T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses.

    Science immunology

    Authors: Emma G Bawden, Teagan Wagner, Jan Schröder, Maike Effern, Daniel Hinze, Lewis Newland, Grace H Attrill, Ariane R Lee, Sven Engel, David Freestone, Marcela de Lima Moreira, Elise Gressier, Nathan McBain, Annabell Bachem, Ashraful Haque, Ruining Dong, Angela L Ferguson, Jarem J Edwards, Peter M Ferguson, Richard A Scolyer, James S Wilmott, Christopher M Jewell, Andrew G Brooks, David E Gyorki, Umaimainthan Palendira, Sammy Bedoui, Jason Waithman, Katharina Hochheiser, Michael Hölzel, Thomas Gebhardt

  • Hypermethylated SHOX2 in circulating cell-free DNA post renal cell carcinoma surgery as TNM-independent biomarker for recurrence risk.

    American journal of translational research

    Authors: Thomas Büttner, Romina Zarbl, Philipp Krausewitz, Sebastian Strieth, Glen Kristiansen, Markus Eckstein, Damian J Ralser, Michael Hölzel, Manuel Ritter, Jörg Ellinger, Dimo Dietrich, Niklas Klümper

  • Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.

    Histopathology

    Authors: Veronika Bahlinger, Annalena Branz, Pamela L Strissel, Reiner Strick, Fabienne Lange, Carol I Geppert, Niklas Klümper, Michael Hölzel, Sven Wach, Helge Taubert, Danijel Sikic, Bernd Wullich, Miriam Angeloni, Fulvia Ferrazzi, Lauri Diehl, Maria Kovalenko, Emon Elboudwarej, Juliane M Jürgensmeier, Arndt Hartmann, Markus Eckstein

  • Multicentric assessment of safety and efficacy of combinatorial adjuvant brain metastasis treatment by intraoperative radiotherapy and immunotherapy.

    International journal of radiation oncology, biology, physics

    Authors: Julian P Layer, Ehab Shiban, Stefanie Brehmer, Christian D Diehl, Douglas Guedes de Castro, Motaz Hamed, Cas S Dejonckheere, Daniel T Cifarelli, Lea L Friker, Ulrich Herrlinger, Michael Hölzel, Hartmut Vatter, Matthias Schneider, Stephanie E Combs, Leonard Christopher Schmeel, Christopher P Cifarelli, Frank A Giordano, Gustavo R Sarria, Klaus-Henning Kahl

  • Adipocyte precursor-derived NRG1 promotes resistance to FGFR inhibition in urothelial carcinoma.

    Cancer research

    Authors: Sana Hosni, Viola Kilian, Niklas Klümper, Daniela Gabbia, Katharina Sieckmann, Dillon Corvino, Anja Winkler, Miriam Saponaro, Karin Woersdoerfer, Doris Schmidt, Oliver Hahn, Ilaria Zanotto, Marina Bertlich, Marieta Toma, Tobias Bald, Markus Eckstein, Michael Hölzel, Matthias Geyer, Manuel Ritter, Dagmar Wachten, Sara De Martin, Abdullah Alajati

  • A replicating LCMV-based vaccine for the treatment of solid tumors.

    Molecular therapy : the journal of the American Society of Gene Therapy

    Authors: Mette-Triin Purde, Jovana Cupovic, Yannick A Palmowski, Ahmad Makky, Sarah Schmidt, Alexander Rochwarger, Fabienne Hartmann, Felix Stemeseder, Alexander Lercher, Marie-Therese Abdou, David Bomze, Lenka Besse, Fiamma Berner, Thomas Tüting, Michael Hölzel, Andreas Bergthaler, Stefan Kochanek, Burkhard Ludewig, Henning Lauterbach, Klaus K Orlinger, Tobias Bald, Andrea Schietinger, Christian M Schürch, Sandra S Ring, Lukas Flatz

  • On-treatment Modified Glasgow Prognostic Score Provides Predictive Information Complementary to Radiological Staging in Metastatic Urothelial Carcinoma on Immunotherapy.

    European urology oncology

    Authors: Jonas Saal, Viktor Grünwald, Tobias Bald, Manuel Ritter, Peter Brossart, Yoshihiko Tomita, Arndt Hartmann, Michael Hölzel, Markus Eckstein, Niklas Klümper

  • Pretreatment albumin is a prognostic and predictive biomarker for response to atezolizumab across solid tumors.

    Clinical & translational immunology

    Authors: Jonas Saal, Jörg Ellinger, Manuel Ritter, Peter Brossart, Michael Hölzel, Niklas Klümper, Tobias Bald

  • () promoter hypomethylation predicts immunotherapy response in metastatic urothelial carcinoma.

    Oncoimmunology

    Authors: Niklas Klümper, Lennert Wüst, Jonas Saal, Damian J Ralser, Romina Zarbl, Jonas Jarczyk, Johannes Breyer, Danijel Sikic, Bernd Wullich, Christian Bolenz, Florian Roghmann, Michael Hölzel, Manuel Ritter, Sebastian Strieth, Arndt Hartmann, Philipp Erben, Ralph M Wirtz, Jennifer Landsberg, Dimo Dietrich, Markus Eckstein