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featured publications

  • The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer.

    European urology

    Authors: Niklas Klümper, Viktor Grünwald, Arndt Hartmann, Michael Hölzel, Markus Eckstein

  • High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma.

    European journal of cancer (Oxford, England : 1990)

    Authors: Niklas Klümper, Alexander Cox, Markus Eckstein, Christoph Kuppe, Manuel Ritter, Peter Brossart, Julian Luetkens, Michael Hölzel, Johannes Stein, Jonas Saal

  • Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    Authors: Niklas Klümper, Ngoc Khanh Tran, Stefanie Zschäbitz, Oliver Hahn, Thomas Büttner, Florian Roghmann, Christian Bolenz, Friedemann Zengerling, Constantin Schwab, Dora Nagy, Marieta Toma, Glen Kristiansen, Hendrik Heers, Philipp Ivanyi, Günter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Arian Farid, Katrin Schlack, Mahmoud Abbas, Can Aydogdu, Jozefina Casuscelli, Theresa Mokry, Michael Mayr, Dora Niedersüß-Beke, Steffen Rausch, Dimo Dietrich, Jonas Saal, Jörg Ellinger, Manuel Ritter, Abdullah Alajati, Christoph Kuppe, Joshua Meeks, Francisco E Vera Badillo, J Alberto Nakauma-González, Joost Boormans, Kerstin Junker, Arndt Hartmann, Viktor Grünwald, Michael Hölzel, Markus Eckstein

  • Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell.

    Nature immunology

    Authors: Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel, Mark J Smyth

  • Integration of on-treatment modified Glasgow prognostic score (mGPS) to improve imaging-based prediction of outcomes in patients with non-small cell lung cancer on immune checkpoint inhibition.

    Lung cancer (Amsterdam, Netherlands)

    Authors: Jonas Saal, Tobias Bald, Markus Eckstein, Damian J Ralser, Peter Brossart, Jörg Ellinger, Michael Hölzel, Niklas Klümper

  • CD4 T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses.

    Science immunology

    Authors: Emma G Bawden, Teagan Wagner, Jan Schröder, Maike Effern, Daniel Hinze, Lewis Newland, Grace H Attrill, Ariane R Lee, Sven Engel, David Freestone, Marcela de Lima Moreira, Elise Gressier, Nathan McBain, Annabell Bachem, Ashraful Haque, Ruining Dong, Angela L Ferguson, Jarem J Edwards, Peter M Ferguson, Richard A Scolyer, James S Wilmott, Christopher M Jewell, Andrew G Brooks, David E Gyorki, Umaimainthan Palendira, Sammy Bedoui, Jason Waithman, Katharina Hochheiser, Michael Hölzel, Thomas Gebhardt

  • Hypermethylated SHOX2 in circulating cell-free DNA post renal cell carcinoma surgery as TNM-independent biomarker for recurrence risk.

    American journal of translational research

    Authors: Thomas Büttner, Romina Zarbl, Philipp Krausewitz, Sebastian Strieth, Glen Kristiansen, Markus Eckstein, Damian J Ralser, Michael Hölzel, Manuel Ritter, Jörg Ellinger, Dimo Dietrich, Niklas Klümper

  • Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts.

    Histopathology

    Authors: Veronika Bahlinger, Annalena Branz, Pamela L Strissel, Reiner Strick, Fabienne Lange, Carol I Geppert, Niklas Klümper, Michael Hölzel, Sven Wach, Helge Taubert, Danijel Sikic, Bernd Wullich, Miriam Angeloni, Fulvia Ferrazzi, Lauri Diehl, Maria Kovalenko, Emon Elboudwarej, Juliane M Jürgensmeier, Arndt Hartmann, Markus Eckstein

  • Multicentric assessment of safety and efficacy of combinatorial adjuvant brain metastasis treatment by intraoperative radiotherapy and immunotherapy.

    International journal of radiation oncology, biology, physics

    Authors: Julian P Layer, Ehab Shiban, Stefanie Brehmer, Christian D Diehl, Douglas Guedes de Castro, Motaz Hamed, Cas S Dejonckheere, Daniel T Cifarelli, Lea L Friker, Ulrich Herrlinger, Michael Hölzel, Hartmut Vatter, Matthias Schneider, Stephanie E Combs, Leonard Christopher Schmeel, Christopher P Cifarelli, Frank A Giordano, Gustavo R Sarria, Klaus-Henning Kahl

  • Adipocyte precursor-derived NRG1 promotes resistance to FGFR inhibition in urothelial carcinoma.

    Cancer research

    Authors: Sana Hosni, Viola Kilian, Niklas Klümper, Daniela Gabbia, Katharina Sieckmann, Dillon Corvino, Anja Winkler, Miriam Saponaro, Karin Woersdoerfer, Doris Schmidt, Oliver Hahn, Ilaria Zanotto, Marina Bertlich, Marieta Toma, Tobias Bald, Markus Eckstein, Michael Hölzel, Matthias Geyer, Manuel Ritter, Dagmar Wachten, Sara De Martin, Abdullah Alajati