Publications

Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization.

14/04/2023 Cancer research

Authors: Matthia A Karreman, Alexander T Bauer, Gergely Solecki, Anna S Berghoff, Chanté D Mayer, Katharina Frey, Nils Hebach, Manuel J Feinauer, Nicole L Schieber, Cedric Tehranian, Luc Mercier, Mahak Singhal, Varun Venkataramani, Marc C Schubert, Daniel Hinze, Michael Hölzel, Iris Helfrich, Dirk Schadendorf, Stefan W Schneider, Dana Westphal, Hellmut G Augustin, Jacky G Goetz, Yannick Schwab, Wolfgang Wick, Frank Winkler

Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance.

14/04/2023 Clinical cancer research : an official journal of the American Association for Cancer Research

Authors: Niklas Klümper, Damian J Ralser, Jörg Ellinger, Florian Roghmann, Julia Albrecht, Eduard Below, Abdullah Alajati, Danijel Sikic, Johannes Breyer, Christian Bolenz, Friedemann Zengerling, Philipp Erben, Kristina Schwamborn, Ralph M Wirtz, Thomas Horn, Dora Nagy, Marieta Toma, Glen Kristiansen, Thomas Büttner, Oliver Hahn, Viktor Grünwald, Christopher Darr, Eva Erne, Steffen Rausch, Jens Bedke, Katrin Schlack, Mahmoud Abbas, Stefanie Zschäbitz, Constantin Schwab, Alexander Mustea, Patrick Adam, Andreas Manseck, Bernd Wullich, Manuel Ritter, Arndt Hartmann, Jürgen Gschwend, Wilko Weichert, Franziska Erlmeier, Michael Hölzel, Markus Eckstein

Molecular Urothelial Tumor Cell Subtypes Remain Stable During Metastatic Evolution.

06/04/2023 European urology

Authors: Alexander Cox, Niklas Klümper, Johannes Stein, Danijel Sikic, Johannes Breyer, Christian Bolenz, Florian Roghmann, Philipp Erben, Ralph M Wirtz, Bernd Wullich, Manuel Ritter, Michael Hölzel, Kristina Schwamborn, Thomas Horn, Jürgen Gschwend, Arndt Hartmann, Wilko Weichert, Franziska Erlmeier, Markus Eckstein

Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma.

01/04/2023 Journal for immunotherapy of cancer

Authors: Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Löffek, Irem Oezel, Roberta Turiello, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Antje Sucker, Eva Hadaschik, Florian Wirsdörfer, Helmut Hanenberg, Niklas Uhlenbrock, Daniel Rauh, Joanna Poźniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Dirk Schadendorf, Jadwiga Jablonska, Michael Hölzel, Iris Helfrich

Early C-reactive protein kinetics predicts immunotherapy response in non-small cell lung cancer in the phase III OAK trial.

01/03/2023 JNCI cancer spectrum

Authors: Jonas Saal, Tobias Bald, Markus Eckstein, Manuel Ritter, Peter Brossart, Jörg Ellinger, Michael Hölzel, Niklas Klümper

Reply to Jon Griffin. TIME for a Change? Multimarker Assessment of the Tumour Immune Microenvironment and Metastatic Site Biopsy to Improve Immunotherapy Response Prediction in Muscle-invasive Bladder Cancer. Eur Urol. 2023;43:143-4.

24/01/2023 European urology

Authors: Niklas Klümper, Michael Hölzel, Markus Eckstein

Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors.

23/01/2023 Med (New York, N.Y.)

Authors: Nicolas Gonzalo Nuñez, Fiamma Berner, Ekaterina Friebel, Susanne Unger, Nina Wyss, Julia Martinez Gomez, Mette-Triin Purde, Rebekka Niederer, Maximilian Porsch, Christa Lichtensteiger, Rafaela Kramer, Michael Erdmann, Christina Schmitt, Lucie Heinzerling, Marie-Therese Abdou, Julia Karbach, Dirk Schadendorf, Lisa Zimmer, Selma Ugurel, Niklas Klümper, Michael Hölzel, Laura Power, Stefanie Kreutmair, Mariaelena Capone, Gabriele Madonna, Lacin Cevhertas, Anja Heider, Teresa Amaral, Omar Hasan Ali, David Bomze, Florentia Dimitriou, Stefan Diem, Paolo Antonio Ascierto, Reinhard Dummer, Elke Jäger, Christoph Driessen, Mitchell Paul Levesque, Willem van de Veen, Markus Joerger, Martin Früh, Burkhard Becher, Lukas Flatz

Five-Fraction Stereotactic Radiotherapy for Brain Metastases-A Retrospective Analysis.

17/01/2023 Current oncology (Toronto, Ont.)

Authors: Julian P Layer, Katharina Layer, Gustavo R Sarria, Fred Röhner, Cas S Dejonckheere, Lea L Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A Giordano, Leonard Christopher Schmeel

CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.

02/01/2023 Scientific reports

Authors: Miriam Saponaro, Sina Flottmann, Markus Eckstein, Oliver Hommerding, Niklas Klümper, Dillon Corvino, Sana Hosni, Anja Schmidt, Nicolas Mönig, Doris Schmidt, Jörg Ellinger, Marieta Toma, Glen Kristiansen, Tobias Bald, Andrea Alimonti, Manuel Ritter, Michael Hölzel, Abdullah Alajati

Single-cell RNA sequencing identifies a population of human liver-type ILC1s.

01/01/2023 Cell reports

Authors: Benjamin Krämer, Ansel P Nalin, Feiyang Ma, Sarah Eickhoff, Philipp Lutz, Sonia Leonardelli, Felix Goeser, Claudia Finnemann, Gudrun Hack, Jan Raabe, Michael ToVinh, Sarah Ahmad, Christoph Hoffmeister, Kim M Kaiser, Steffen Manekeller, Vittorio Branchi, Tobias Bald, Michael Hölzel, Robert Hüneburg, Hans Dieter Nischalke, Alexander Semaan, Bettina Langhans, Dominik J Kaczmarek, Brooke Benner, Matthew R Lordo, Jesse Kowalski, Adam Gerhardt, Jörg Timm, Marieta Toma, Raphael Mohr, Andreas Türler, Arthur Charpentier, Tobias van Bremen, Georg Feldmann, Arne Sattler, Katja Kotsch, Ali T Abdallah, Christian P Strassburg, Ulrich Spengler, William E Carson, Bethany L Mundy-Bosse, Matteo Pellegrini, Timothy E O'Sullivan, Aharon G Freud, Jacob Nattermann