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featured publications

  • promoter hypomethylation is a negative prognostic biomarker at initial diagnosis but predicts response and favorable outcome to anti-PD-1 based immunotherapy in clear cell renal cell carcinoma.

    Journal for immunotherapy of cancer

    Authors: Niklas Klümper, Damian J Ralser, Romina Zarbl, Katrin Schlack, Andres Jan Schrader, Marc Rehlinghaus, Michèle J Hoffmann, Günter Niegisch, Annemarie Uhlig, Lutz Trojan, Julie Steinestel, Konrad Steinestel, Ralph M Wirtz, Danijel Sikic, Markus Eckstein, Glen Kristiansen, Marieta Toma, Michael Hölzel, Manuel Ritter, Sebastian Strieth, Jörg Ellinger, Dimo Dietrich

  • FORGE: A Novel Scoring System to Predict the MIB-1 Labeling Index in Intracranial Meningiomas.

    Cancers

    Authors: Johannes Wach, Tim Lampmann, Ági Güresir, Patrick Schuss, Hartmut Vatter, Ulrich Herrlinger, Albert Becker, Michael Hölzel, Marieta Toma, Erdem Güresir

  • Top publication

    LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.

    Nature biotechnology

    Authors: Kerstin U Ludwig, Ricarda M Schmithausen, David Li, Max L Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M Hochfeld, Eva C Beins, Ines H Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Eva-Maria C Moench, Jacob D Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus M Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L Schmid-Burgk

  • Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility.

    Frontiers in cell and developmental biology

    Authors: Lucia A Torres-Fernández, Jana Emich, Yasmine Port, Sibylle Mitschka, Marius Wöste, Simon Schneider, Daniela Fietz, Manon S Oud, Sara Di Persio, Nina Neuhaus, Sabine Kliesch, Michael Hölzel, Hubert Schorle, Corinna Friedrich, Frank Tüttelmann, Waldemar Kolanus

  • Druggable epigenetic suppression of interferon-induced chemokine expression linked to amplification in neuroblastoma.

    Journal for immunotherapy of cancer

    Authors: Johanna A Seier, Julia Reinhardt, Kritika Saraf, Susanna S Ng, Julian P Layer, Dillon Corvino, Kristina Althoff, Frank A Giordano, Alexander Schramm, Matthias Fischer, Michael Hölzel

  • The myeloid cell type I IFN system promotes antitumor immunity over pro-tumoral inflammation in cancer T-cell therapy.

    Clinical & translational immunology

    Authors: Janne Ruotsalainen, Dorys Lopez-Ramos, Meri Rogava, Naveen Shridhar, Nicole Glodde, Evelyn Gaffal, Michael Hölzel, Tobias Bald, Thomas Tüting

  • Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers.

    Cancers

    Authors: Niklas Klümper, Marthe von Danwitz, Johannes Stein, Doris Schmidt, Anja Schmidt, Glen Kristiansen, Michael Muders, Michael Hölzel, Manuel Ritter, Abdullah Alajati, Jörg Ellinger

  • Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis.

    Oncogenesis

    Authors: Silke Nothdurft, Clotilde Thumser-Henner, Frank Breitenbücher, Ross A Okimoto, Madeleine Dorsch, Christiane A Opitz, Ahmed Sadik, Charlotte Esser, Michael Hölzel, Saurabh Asthana, Jan Forster, Daniela Beisser, Sophie Kalmbach, Barbara M Grüner, Trever G Bivona, Alexander Schramm, Martin Schuler

  • CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8 T Cells.

    Immunity

    Authors: Matthias Braun, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, Luize G Lima, Lizeth G Meza Guzman, Kunlun Li, Rui Li, Nazhifah Salim, Maria Villancanas Jorge, Sunyoung Ham, Gabrielle Kelly, Frank Vari, Ailin Lepletier, Ashwini Raghavendra, Sally Pearson, Jason Madore, Sebastien Jacquelin, Maike Effern, Brodie Quine, Lambros T Koufariotis, Mika Casey, Kyohei Nakamura, Eun Y Seo, Michael Hölzel, Matthias Geyer, Glen Kristiansen, Touraj Taheri, Elizabeth Ahern, Brett G M Hughes, James S Wilmott, Georgina V Long, Richard A Scolyer, Martin D Batstone, Jennifer Landsberg, Dimo Dietrich, Oltin T Pop, Lukas Flatz, William C Dougall, André Veillette, Sandra E Nicholson, Andreas Möller, Robert J Johnston, Ludovic Martinet, Mark J Smyth, Tobias Bald

  • BATF3 programs CD8 T cell memory.

    Nature immunology

    Authors: Marco A Ataide, Karl Komander, Konrad Knöpper, Annika E Peters, Hao Wu, Sarah Eickhoff, Tea Gogishvili, Justus Weber, Anika Grafen, Axel Kallies, Natalio Garbi, Hermann Einsele, Michael Hudecek, Georg Gasteiger, Michael Hölzel, Martin Vaeth, Wolfgang Kastenmüller