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featured publications

  • Melanoma Brain Metastases Patient-Derived Organoids: An In Vitro Platform for Drug Screening.

    Pharmaceutics

    Authors: Saif-Eldin Abedellatif, Racha Hosni, Andreas Waha, Gerrit H Gielen, Mohammed Banat, Motaz Hamed, Erdem Güresir, Anne Fröhlich, Judith Sirokay, Anna-Lena Wulf, Glen Kristiansen, Torsten Pietsch, Hartmut Vatter, Michael Hölzel, Matthias Schneider, Marieta Ioana Toma

  • Membranous expression of target protein is required for ADC response in urothelial cancer.

    European urology

    Authors: Niklas Klümper, Johannes Brägelmann, Veronika Bahlinger, Arndt Hartmann, Viktor Grünwald, Christoph Kuppe, Michael Hölzel, Markus Eckstein

  • Exploring membranous NECTIN-4 expression patterns and enfortumab vedotin response in prostate cancer.

    Journal of cellular and molecular medicine

    Authors: Richard Weiten, Marit Bernhardt, Max Niemann, Glen Kristiansen, Viktor Grünwald, Manuel Ritter, Michael Hölzel, Markus Eckstein, Abdullah Alajati, Niklas Klümper, Philipp Krausewitz

  • Preclinical evidence for the use of anti-Trop-2 antibody-drug conjugate Sacituzumab govitecan in cerebral metastasized castration-resistant prostate cancer.

    Cancer medicine

    Authors: Richard Weiten, Max Niemann, Eduard Below, Lea L Friker, Damian J Ralser, Marieta Toma, Glen Kristiansen, Oliver Hahn, Sabrina Zechel, Viktor Grünwald, Tobias Bald, Johannes Siewert, Torsten Pietsch, Manuel Ritter, Michael Hölzel, Markus Eckstein, Abdullah Alajati, Philipp Krausewitz, Niklas Klümper

  • L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial.

    Nature communications

    Authors: Frank A Giordano, Julian P Layer, Sonia Leonardelli, Lea L Friker, Roberta Turiello, Dillon Corvino, Thomas Zeyen, Christina Schaub, Wolf Müller, Elena Sperk, Leonard Christopher Schmeel, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Torsten Pietsch, Sotirios Bisdas, Michael Platten, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel

  • The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer.

    European urology

    Authors: Niklas Klümper, Viktor Grünwald, Arndt Hartmann, Michael Hölzel, Markus Eckstein

  • High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma.

    European journal of cancer (Oxford, England : 1990)

    Authors: Niklas Klümper, Alexander Cox, Markus Eckstein, Christoph Kuppe, Manuel Ritter, Peter Brossart, Julian Luetkens, Michael Hölzel, Johannes Stein, Jonas Saal

  • Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    Authors: Niklas Klümper, Ngoc Khanh Tran, Stefanie Zschäbitz, Oliver Hahn, Thomas Büttner, Florian Roghmann, Christian Bolenz, Friedemann Zengerling, Constantin Schwab, Dora Nagy, Marieta Toma, Glen Kristiansen, Hendrik Heers, Philipp Ivanyi, Günter Niegisch, Camilla Marisa Grunewald, Christopher Darr, Arian Farid, Katrin Schlack, Mahmoud Abbas, Can Aydogdu, Jozefina Casuscelli, Theresa Mokry, Michael Mayr, Dora Niedersüß-Beke, Steffen Rausch, Dimo Dietrich, Jonas Saal, Jörg Ellinger, Manuel Ritter, Abdullah Alajati, Christoph Kuppe, Joshua Meeks, Francisco E Vera Badillo, J Alberto Nakauma-González, Joost Boormans, Kerstin Junker, Arndt Hartmann, Viktor Grünwald, Michael Hölzel, Markus Eckstein

  • Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell.

    Nature immunology

    Authors: Yulong Gao, Fernando Souza-Fonseca-Guimaraes, Tobias Bald, Susanna S Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nic Waddell, Stephen J Blake, Juming Yan, Laurent Bartholin, Jason S Lee, Eric Vivier, Kazuyoshi Takeda, Meriem Messaoudene, Laurence Zitvogel, Michele W L Teng, Gabrielle T Belz, Christian R Engwerda, Nicholas D Huntington, Kyohei Nakamura, Michael Hölzel, Mark J Smyth

  • Integration of on-treatment modified Glasgow prognostic score (mGPS) to improve imaging-based prediction of outcomes in patients with non-small cell lung cancer on immune checkpoint inhibition.

    Lung cancer (Amsterdam, Netherlands)

    Authors: Jonas Saal, Tobias Bald, Markus Eckstein, Damian J Ralser, Peter Brossart, Jörg Ellinger, Michael Hölzel, Niklas Klümper