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Prof. Dr. Özgün Gökce

Member

Medical Faculty, University of Bonn & German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1/99 D-53127 Bonn Germany

Ozgun.Goekce@ukbonn.de

Website

Our research group represents a synergistic fusion of multi disciplinary expertise, striving to unravel the complexities of age-related brain disorders through the development of cutting-edge quantitative genomics techniques. Our mission is to decode the cellular responses underlying the aging process and to dissect the molecular mechanisms driving neurodevelopmental and neurodegenerative disorders. To achieve these objectives, we develop and integrate state-of-the-art technologies, including single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), electron microscopy, and machine learning algorithms, forging a comprehensive and holistic understanding of these critical biological processes.

Ozgun Gokce

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Recent publications

  • Chronic progressive demyelination induces a microglial state with lysosomal dysfunction.

    Nature neuroscience

    Authors: Stefan A Berghoff, Lena Spieth, Simona Vitale, Lennart Schlaphoff, Martin Zirngibl, Niklas Junker, Alan-Charles Dean, Lu Liu, Alkmini Damkou, Stefan Roth, Charlene-Annett Hurler, Leon Hosang, Katrin Perez Anderson, Simon Besson-Girard, Marvin Reich, Astrid Feiten, Ludwig Huber, Christoph Müller, Georg Kislinger, Lina Dinkel, Yakum B Nkeh, Janos Groh, Anna Williams, Arthur Liesz, Martina Schifferer, Gesine Saher, Klaus-Armin Nave, Sarah Jäkel, Sabina Tahirovic, Martin Giera, Ozgun Gokce, Mikael Simons

  • Author Correction: T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

    Nature neuroscience

    Authors: Shreeya Kedia, Hao Ji, Ruoqing Feng, Peter Androvic, Lena Spieth, Lu Liu, Jonas Franz, Hanna Zdiarstek, Katrin Perez Anderson, Cem Kaboglu, Qian Liu, Nicola Mattugini, Fatma Cherif, Danilo Prtvar, Ludovico Cantuti-Castelvetri, Arthur Liesz, Martina Schifferer, Christine Stadelmann, Sabina Tahirovic, Ozgun Gokce, Mikael Simons

  • Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions.

    Immunity

    Authors: Ruoqing Feng, Lena Spieth, Lu Liu, Stefan Berghoff, Jonas Franz, Qian Liu, Zhen Wang, Vini Tiwari, Simona Vitale, Simon Frerich, Sergi Florensa, Niklas Junker, Ludwig Huber, Marco Keller, Christoph Müller, Franz Bracher, Xiaoke Ge, Patrick C N Rensen, Gijs Kooij, Leon Hosang, Serhii Chornyi, Martin Dichgans, Ozgun Gokce, Gesine Saher, Christine Stadelmann, Martin Giera, Janos Groh, Mikael Simons

All publications by Prof. Dr. Özgün Gökce