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  • Chronic progressive demyelination induces a microglial state with lysosomal dysfunction.

    Nature neuroscience

    Authors: Stefan A Berghoff, Lena Spieth, Simona Vitale, Lennart Schlaphoff, Martin Zirngibl, Niklas Junker, Alan-Charles Dean, Lu Liu, Alkmini Damkou, Stefan Roth, Charlene-Annett Hurler, Leon Hosang, Katrin Perez Anderson, Simon Besson-Girard, Marvin Reich, Astrid Feiten, Ludwig Huber, Christoph Müller, Georg Kislinger, Lina Dinkel, Yakum B Nkeh, Janos Groh, Anna Williams, Arthur Liesz, Martina Schifferer, Gesine Saher, Klaus-Armin Nave, Sarah Jäkel, Sabina Tahirovic, Martin Giera, Ozgun Gokce, Mikael Simons

  • Author Correction: T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

    Nature neuroscience

    Authors: Shreeya Kedia, Hao Ji, Ruoqing Feng, Peter Androvic, Lena Spieth, Lu Liu, Jonas Franz, Hanna Zdiarstek, Katrin Perez Anderson, Cem Kaboglu, Qian Liu, Nicola Mattugini, Fatma Cherif, Danilo Prtvar, Ludovico Cantuti-Castelvetri, Arthur Liesz, Martina Schifferer, Christine Stadelmann, Sabina Tahirovic, Ozgun Gokce, Mikael Simons

  • Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions.

    Immunity

    Authors: Ruoqing Feng, Lena Spieth, Lu Liu, Stefan Berghoff, Jonas Franz, Qian Liu, Zhen Wang, Vini Tiwari, Simona Vitale, Simon Frerich, Sergi Florensa, Niklas Junker, Ludwig Huber, Marco Keller, Christoph Müller, Franz Bracher, Xiaoke Ge, Patrick C N Rensen, Gijs Kooij, Leon Hosang, Serhii Chornyi, Martin Dichgans, Ozgun Gokce, Gesine Saher, Christine Stadelmann, Martin Giera, Janos Groh, Mikael Simons

  • Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.

    Nature communications

    Authors: Ali Rezaei, Virág Kocsis-Jutka, Zeynep I Gunes, Qing Zeng, Georg Kislinger, Franz Bauernschmitt, Huseyin Berkcan Isilgan, Laura R Parisi, Tuğberk Kaya, Sören Franzenburg, Jonas Koppenbrink, Julia Knogler, Thomas Arzberger, Daniel Farny, Brigitte Nuscher, Eszter Katona, Ashutosh Dhingra, Chao Yang, Garyfallia Gouna, Katherine D LaClair, Aleksandar Janjic, Wolfgang Enard, Qihui Zhou, Nellwyn Hagan, Dimitry Ofengeim, Eduardo Beltrán, Ozgun Gokce, Mikael Simons, Sabine Liebscher, Dieter Edbauer

  • An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis.

    Nature communications

    Authors: Omar El Bounkari, Chunfang Zan, Bishan Yang, Simon Ebert, Jonas Wagner, Elina Bugar, Naomi Kramer, Priscila Bourilhon, Christos Kontos, Marlies Zarwel, Dzmitry Sinitski, Jelena Milic, Yvonne Jansen, Wolfgang E Kempf, Nadja Sachs, Lars Maegdefessel, Hao Ji, Ozgun Gokce, Fabien Riols, Mark Haid, Simona Gerra, Adrian Hoffmann, Markus Brandhofer, Maida Avdic, Richard Bucala, Remco T A Megens, Nienke Willemsen, Denise Messerer, Christian Schulz, Alexander Bartelt, Tobias Harm, Dominik Rath, Yvonne Döring, Meinrad Gawaz, Christian Weber, Aphrodite Kapurniotu, Jürgen Bernhagen

  • Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.

    Nature neuroscience

    Authors: Boyan Bonev, Gonçalo Castelo-Branco, Fei Chen, Simone Codeluppi, M Ryan Corces, Jean Fan, Myriam Heiman, Kenneth Harris, Fumitaka Inoue, Manolis Kellis, Ariel Levine, Mo Lotfollahi, Chongyuan Luo, Kristen R Maynard, Mor Nitzan, Vijay Ramani, Rahul Satijia, Lucas Schirmer, Yin Shen, Na Sun, Gilad S Green, Fabian Theis, Xiao Wang, Joshua D Welch, Ozgun Gokce, Genevieve Konopka, Shane Liddelow, Evan Macosko, Omer Ali Bayraktar, Naomi Habib, Tomasz J Nowakowski

  • Implementation and validation of single-cell genomics experiments in neuroscience.

    Nature neuroscience

    Authors: Marco Colonna, Genevieve Konopka, Shane A Liddelow, Tomasz Nowakowski, Rajeshwar Awatramani, Helen S Bateup, Cathryn R Cadwell, Emre Caglayan, Jerry L Chen, Jesse Gillis, Martin Kampmann, Fenna Krienen, Samuel E Marsh, Michelle Monje, Michael R O'Dea, Rickie Patani, Alex A Pollen, Francisco J Quintana, Marissa Scavuzzo, Matthew Schmitz, Steven A Sloan, Paul J Tesar, Jessica Tollkuhn, Maria Antonietta Tosches, Madeleine E Urbanek, Jonathan M Werner, Omer A Bayraktar, Ozgun Gokce, Naomi Habib

  • Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system.

    Nature neuroscience

    Authors: Igor Adameyko, Trygve Bakken, Aparna Bhaduri, Chintan Chhatbar, Mariella G Filbin, David Gate, Hannah Hochgerner, Chang Nam Kim, Jordan Krull, Gioele La Manno, Qingyun Li, Sten Linnarsson, Qin Ma, Christian Mayer, Vilas Menon, Patricia Nano, Marco Prinz, Steve Quake, Christopher A Walsh, Jin Yang, Omer Ali Bayraktar, Ozgun Gokce, Naomi Habib, Genevieve Konopka, Shane A Liddelow, Tomasz J Nowakowski

  • Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery.

    Nature neuroscience

    Authors: Boyan Bonev, Castelo-Branco Gonçalo, Fei Chen, Simone Codeluppi, M Ryan Corces, Jean Fan, Myriam Heiman, Kenneth Harris, Fumitaka Inoue, Manolis Kellis, Ariel Levine, Mo Lotfollahi, Chongyuan Luo, Kristen R Maynard, Mor Nitzan, Vijay Ramani, Rahul Satijia, Lucas Schirmer, Yin Shen, Na Sun, Gilad S Green, Fabian Theis, Xiao Wang, Joshua D Welch, Ozgun Gokce, Genevieve Konopka, Shane Liddelow, Evan Macosko, Omer Bayraktar, Naomi Habib, Tomasz J Nowakowski

  • Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system.

    Immunity

    Authors: Vini Tiwari, Bharat Prajapati, Yaw Asare, Alkmini Damkou, Hao Ji, Lu Liu, Nawraa Naser, Garyfallia Gouna, Katarzyna B Leszczyńska, Jakub Mieczkowski, Martin Dichgans, Qing Wang, Riki Kawaguchi, Zechuan Shi, Vivek Swarup, Daniel H Geschwind, Marco Prinz, Ozgun Gokce, Mikael Simons