Skip to main content

Prof. Dr. Rayk Behrendt

Member, Steering-Committee Member

Institute of Clinical Chemistry and Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg-Campus 1 53105 Bonn

behrendt@uni-bonn.de

Website

We investigate under which conditions endogenous nucleic acids can activate nucleic acid sensors of the innate immune system. Over the last 20 years innate immune recognition of nucleic acids has been established as a central mechanism driving inflammation of sterile and of infectious etiologies. In the future, we will build upon the knowledge gained from studying disease to understand the role of nucleic acid immunity in health.

Rayk_Behrendt

Recent publications

  • Host restriction factor SAMHD1 does not restrict seasonal influenza virus replication in human epithelial or macrophage-like cells.

    Virology journal

    Authors: Yongyan Xia, Rubaiyea Farrukee, Andrew G Brooks, Sofía Soler, Rayk Behrendt, Eva Bartok, Sarah L Londrigan, Patrick C Reading

  • Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis.

    Science immunology

    Authors: Saya Satoh, Yaw Bia Tan, Benjamin Heil, Shintaro Yamada, Verena Schütte, Celest Phang, Chaozhi Tang, Yuta Tsukamoto, Takahiro Higuchi, Takashi Fujita, Rayk Behrendt, Martin Schlee, Dahai Luo, Hiroki Kato

  • Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling.

    eLife

    Authors: Hella Luksch, Felix Schulze, David Geißler-Lösch, David Sprott, Lennart Höfs, Eva M Szegö, Wulf Tonnus, Stefan Winkler, Claudia Günther, Andreas Linkermann, Rayk Behrendt, Lino L Teichmann, Björn H Falkenburger, Angela Rösen-Wolff

All publications by Prof. Dr. Rayk Behrendt