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featured publications

  • Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis.

    Science immunology

    Authors: Saya Satoh, Yaw Bia Tan, Benjamin Heil, Shintaro Yamada, Verena Schütte, Celest Phang, Chaozhi Tang, Yuta Tsukamoto, Takahiro Higuchi, Takashi Fujita, Rayk Behrendt, Martin Schlee, Dahai Luo, Hiroki Kato

  • Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling.

    eLife

    Authors: Hella Luksch, Felix Schulze, David Geißler-Lösch, David Sprott, Lennart Höfs, Eva M Szegö, Wulf Tonnus, Stefan Winkler, Claudia Günther, Andreas Linkermann, Rayk Behrendt, Lino L Teichmann, Björn H Falkenburger, Angela Rösen-Wolff

  • Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy.

    Signal transduction and targeted therapy

    Authors: Zhaorong Chen, Rayk Behrendt, Lennart Wild, Martin Schlee, Christian Bode

  • The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.

    Cellular and molecular life sciences : CMLS

    Authors: Onur Kerem Tever, Torben Mentrup, Ivan Kingyue Chinn, Hitoshi Ishikuma, Regina Fluhrer, Marc Schmitz, Rebekka Wehner, Rayk Behrendt, Javier Chinen, Bernd Schröder

  • NIS-Seq enables cell-type-agnostic optical perturbation screening.

    Nature biotechnology

    Authors: Caroline I Fandrey, Marius Jentzsch, Peter Konopka, Alexander Hoch, Katja Blumenstock, Afraa Zackria, Salie Maasewerd, Marta Lovotti, Dorothee J Lapp, Florian N Gohr, Piotr Suwara, Jędrzej Świeżewski, Lukas Rossnagel, Fabienne Gobs, Maia Cristodaro, Lina Muhandes, Rayk Behrendt, Martin C Lam, Klaus J Walgenbach, Tobias Bald, Florian I Schmidt, Eicke Latz, Jonathan L Schmid-Burgk

  • Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP kinase inhibition against BRAF-mutated melanoma.

    Molecular therapy. Nucleic acids

    Authors: Christian Grützner, Yu Pan Tan, Patrick Müller, Thais M Schlee-Guimaraes, Marius Jentzsch, Jonathan L Schmid-Burgk, Marcel Renn, Rayk Behrendt, Gunther Hartmann

  • Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.

    Science advances

    Authors: Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato

  • Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells.

    Molecular therapy : the journal of the American Society of Gene Therapy

    Authors: Erika Valeri, Giulia Unali, Francesco Piras, Monah Abou-Alezz, Giulia Pais, Fabrizio Benedicenti, Maria Rosa Lidonnici, Ivan Cuccovillo, Ilaria Castiglioni, Sergio Arévalo, Giulio Spinozzi, Ivan Merelli, Rayk Behrendt, Adrian Oo, Baek Kim, Nathaniel R Landau, Giuliana Ferrari, Eugenio Montini, Anna Kajaste-Rudnitski

  • Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages.

    Nature aging

    Authors: Nilushi S De Silva, Johan Siewiera, Chantal Alkhoury, Guilherme P F Nader, Francesca Nadalin, Kevin de Azevedo, Mickaël Couty, Helena M Izquierdo, Anvita Bhargava, Cécile Conrad, Mathieu Maurin, Konstantina Antoniadou, Charles Fouillade, Arturo Londono-Vallejo, Rayk Behrendt, Karine Bertotti, Cindy Serdjebi, François Lanthiez, Lisa Gallwitz, Paul Saftig, Beatriz Herrero-Fernández, Angela Saez, José María González-Granado, Guillaume van Niel, Alexandre Boissonnas, Matthieu Piel, Nicolas Manel

  • Activation of the cGAS/STING axis in genome-damaged hematopoietic cells does not impact blood cell formation or leukemogenesis.

    Cancer research

    Authors: Nicole Dressel, Loreen Natusch, Clara M Munz, Santiago Costas Ramon, Mina N F Morcos, Anja Loff, Björn Hiller, Christa Haase, Livia Schulze, Patrick Müller, Mathias Lesche, Andreas Dahl, Hella Luksch, Angela Roesen-Wolff, Axel Roers, Rayk Behrendt, Alexander Gerbaulet