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Prof. Dr. Sven Wehner


Department of Surgery

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

+49 228 28711007


The aim of our research is to identify (neuro)-immunological mechanisms contributing to acute (postoperative) and chronic functional disturbances of the GI tract. In a series of publications our group demonstrated that interactions of resident immune cells and the enteric nervous system trigger postoperative bowel wall inflammation. This local neuroinflammation can be effectively modified by intrinsic and extrinsic neurotransmitters. With international collaborators we also investigate the neuroimmunology of chronic inflammatory bowel diseases. Currently, we are aiming to understand the initial trigger mechanisms of intestinal inflammation as well as to identify novel neuro-immune modulatory pathways. This will help us to gather a comprehensive understanding of acute and chronic intestinal inflammatory disorders.

Recent publications

  • β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery.

    Journal of neuroinflammation

    Authors: Patrick Leven, Reiner Schneider, Linda Schneider, Shilpashree Mallesh, Pieter Vanden Berghe, Philipp Sasse, Jörg C Kalff, Sven Wehner

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  • Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α.

    Scientific reports

    Authors: Anne S Ten Hove, Shilpashree Mallesh, Konstantina Zafeiropoulou, Janna W M de Kleer, Patricia H P van Hamersveld, Olaf Welting, Theodorus B M Hakvoort, Sven Wehner, Jurgen Seppen, Wouter J de Jonge

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  • Glial cell-derived soluble factors increase the metastatic potential of pancreatic adenocarcinoma cells and induce epithelial-to-mesenchymal transition.

    Journal of cancer research and clinical oncology

    Authors: Balbina García-Reyes, Ivan Kuzmanov, Reiner Schneider, Bianca Schneiker, Patrik Efferz, Jörg C Kalff, Sven Wehner

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