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Prof. Dr. Sven Wehner

Member, Steering-Committee Member

Department of Surgery

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

Sven.Wehner@ukbonn.de

+49 228 28711007

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The aim of our research is to identify (neuro)-immunological mechanisms contributing to acute (postoperative) and chronic functional disturbances of the GI tract. In a series of publications our group demonstrated that interactions of resident immune cells and the enteric nervous system trigger postoperative bowel wall inflammation. This local neuroinflammation can be effectively modified by intrinsic and extrinsic neurotransmitters. With international collaborators we also investigate the neuroimmunology of chronic inflammatory bowel diseases. Currently, we are aiming to understand the initial trigger mechanisms of intestinal inflammation as well as to identify novel neuro-immune modulatory pathways. This will help us to gather a comprehensive understanding of acute and chronic intestinal inflammatory disorders.

Sven Wehner

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Recent publications

  • Mast cell activation within the mesentery depends on vagal signaling following abdominal surgery.

    Surgery open science

    Authors: Anna Woestemeier, Timo Schwandt, Philipp Lingohr, Mariola Lysson, Sven Wehner, Jörg C Kalff, Gun-Soo Hong

  • Glial Connexin-43 is a pathogenic mechanism promoting gut inflammation after postsurgical intestinal manipulation with potential relevance to humans.

    Cellular and molecular gastroenterology and hepatology

    Authors: Samhita Chaudhuri, Reiner Schneider, Dmitrii Pavlov, Alix Zuleta Alarcon, Elvio Mazzotta, Jonathon L McClain, Patrick Leven, Paolo Fadda, Manekeller Steffen, Yunpeng Du, Alan Harzman, Brian D Gulbransen, Sven Wehner, Fievos L Christofi

  • Tryptophan indole metabolites reduce anastomotic leakage through aryl hydrocarbon receptor-driven interleukin-22 production.

    Cellular and molecular gastroenterology and hepatology

    Authors: Vasiliki Bantavi, Laura Gloeck, Patrick Leven, Konstantina Zafeiropoulou, Olaf Welting, Hilal Sengül, Patrik Efferz, Bianca Schneiker, Timothy Ryan McCulloch, Christoph Wilhelm, Sandra Blaess, Anneke Fuss, Joep P M Derikx, Bruno Sovran, Wouter J de Jonge, Sven Wehner

All publications by Prof. Dr. Sven Wehner