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Publications

featured publications

  • Glial Connexin-43 is a pathogenic mechanism promoting gut inflammation after postsurgical intestinal manipulation with potential relevance to humans.

    Cellular and molecular gastroenterology and hepatology

    Authors: Samhita Chaudhuri, Reiner Schneider, Dmitrii Pavlov, Alix Zuleta Alarcon, Elvio Mazzotta, Jonathon L McClain, Patrick Leven, Paolo Fadda, Manekeller Steffen, Yunpeng Du, Alan Harzman, Brian D Gulbransen, Sven Wehner, Fievos L Christofi

  • Tryptophan indole metabolites reduce anastomotic leakage through aryl hydrocarbon receptor-driven interleukin-22 production.

    Cellular and molecular gastroenterology and hepatology

    Authors: Vasiliki Bantavi, Laura Gloeck, Patrick Leven, Konstantina Zafeiropoulou, Olaf Welting, Hilal Sengül, Patrik Efferz, Bianca Schneiker, Timothy Ryan McCulloch, Christoph Wilhelm, Sandra Blaess, Anneke Fuss, Joep P M Derikx, Bruno Sovran, Wouter J de Jonge, Sven Wehner

  • Using protease inhibitors to prevent intraperitoneal adhesions: effects of nafamostat mesylate, UAMC-00050, GM6001, and enoxaparin in the cecal ligation and puncture model and the ischemic button model.

    Surgery today

    Authors: Philip Plaeke, Joris De Man, Gun-Soo Hong, Michelle de Bruyn, Ingrid De Meester, Philippe G Jorens, Koen Augustyns, Joerg C Kalff, Sven Wehner, Guy Hubens, Benedicte De Winter

  • Layer-specific molecular signatures of colon anastomotic healing and leakage in mice.

    Molecular medicine (Cambridge, Mass.)

    Authors: Hilal Sengul, Vasiliki Bantavi, Laura Gloeck, Andrew Y F Li Yim, Patrick Leven, Patrik Efferz, Bianca Schneiker, Mariola Lysson, Wouter J De Jonge, Sven Wehner

  • Macrophage-induced enteric neurodegeneration leads to motility impairment during gut inflammation.

    EMBO molecular medicine

    Authors: Mona Breßer, Kevin D Siemens, Linda Schneider, Jonah E Lunnebach, Patrick Leven, Tim R Glowka, Kristin Oberländer, Elena De Domenico, Joachim L Schultze, Joachim Schmidt, Jörg C Kalff, Anja Schneider, Sven Wehner, Reiner Schneider

  • Extracellular matrix substrates differentially influence enteric glial cell homeostasis and immune reactivity.

    Frontiers in immunology

    Authors: Linda Schneider, Reiner Schneider, Ebrahim Hamza, Sven Wehner

  • IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer.

    Nature communications

    Authors: Lies van Baarle, Veronica De Simone, Linda Schneider, Sneha Santhosh, Saeed Abdurahiman, Francesca Biscu, Reiner Schneider, Lisa Zanoletti, Renata Siqueira de Mello, Sara Verbandt, Zedong Hu, Michelle Stakenborg, Bo-Jun Ke, Nathalie Stakenborg, Raquel Salvador Laureano, Balbina García-Reyes, Jonas Henn, Marieta Toma, Maxime Vanmechelen, Guy Boeckxstaens, Frederik De Smet, Abhishek D Garg, Sales Ibiza, Sabine Tejpar, Sven Wehner, Gianluca Matteoli

  • β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery.

    Journal of neuroinflammation

    Authors: Patrick Leven, Reiner Schneider, Linda Schneider, Shilpashree Mallesh, Pieter Vanden Berghe, Philipp Sasse, Jörg C Kalff, Sven Wehner

  • Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α.

    Scientific reports

    Authors: Anne S Ten Hove, Shilpashree Mallesh, Konstantina Zafeiropoulou, Janna W M de Kleer, Patricia H P van Hamersveld, Olaf Welting, Theodorus B M Hakvoort, Sven Wehner, Jurgen Seppen, Wouter J de Jonge

  • Glial cell-derived soluble factors increase the metastatic potential of pancreatic adenocarcinoma cells and induce epithelial-to-mesenchymal transition.

    Journal of cancer research and clinical oncology

    Authors: Balbina García-Reyes, Ivan Kuzmanov, Reiner Schneider, Bianca Schneiker, Patrik Efferz, Jörg C Kalff, Sven Wehner