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Prof. Dr. Radoslaw Nowak

Member

Institute of Structural Biology

BMZ I, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn

radoslaw.nowak@uni-bonn.de

Our mission is to explore therapeutic potential of small molecule induced proximity in inflammation and cancer. The laboratory focuses on targeted protein degradation, discovery and mechanistic characterization of novel molecular glues/induced proximity and development of technology for exploration of gain of function pharmacology.

Institut für Strukturbiologie, Uniklinik Bonn

Recent publications

  • Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.

    Molecular cell

    Authors: Mikołaj Słabicki, Jiho Park, Radosław P Nowak, Shourya S Roy Burman, Jesse Pellman, Charles Zou, Hlib Razumkov, Jeannie Carreiro, Simran Rastogi, Anna Goldstein, Marek M Nagiec, Katherine A Donovan, Jianwei Che, Moritz Hunkeler, Qixiang Geng, Chi-Lin Hsu, Megha Lakshminarayan, Chelsea Shu, Rebecca L Zon, Zuzanna Kozicka, Paul M C Park, Jonathan M Tsai, Hojong Yoon, Lyn H Jones, Adam S Sperling, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert

  • Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6.

    RSC medicinal chemistry

    Authors: Silas L Wurnig, Maria Hanl, Thomas M Geiger, Shiyang Zhai, Ina Dressel, Dominika E Pieńkowska, Radosław P Nowak, Finn K Hansen

  • An engineered cereblon optimized for high throughput screening and molecular glue discovery.

    Cell chemical biology

    Authors: Henry J Bailey, Jonathan Eisert, Rubina Kazi, Jan Gerhartz, Dominika Ewa Pieńkowska, Ina Dressel, Joshua Vollrath, Ivan Kondratov, Tetiana Matviyuk, Nataliya Tolmachova, Varun Jayeshkumar Shah, Giulio Giuliani, Thorsten Mosler, Thomas M Geiger, Ana M Esteves, Sandra P Santos, Raquel L Sousa, Tiago M Bandeiras, Eva-Maria Leibrock, Ulrike Bauer, Birgitta Leuthner, Julian D Langer, Ansgar A Wegener, Radosław P Nowak, Fiona J Sorrell, Ivan Dikic

All publications by Prof. Dr. Radoslaw Nowak