Skip to main content

Prof. Dr. Radoslaw Nowak

Member

Institute of Structural Biology

BMZ I, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn

radoslaw.nowak@uni-bonn.de

Our mission is to explore therapeutic potential of small molecule induced proximity in inflammation and cancer. The laboratory focuses on targeted protein degradation, discovery and mechanistic characterization of novel molecular glues/induced proximity and development of technology for exploration of gain of function pharmacology.

Institut für Strukturbiologie, Uniklinik Bonn

Recent publications

  • Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies.

    Journal of medicinal chemistry

    Authors: Shiyang Zhai, Marie Kemkes, Cindy-Esther Kponomaizoun, Jan Gerhartz, Felix Feller, Jia-Wey Tu, Dominika Ewa Pieńkowska, Julian Schliehe-Diecks, Ina Dressel, Michael Gütschow, Radosław P Nowak, Christian Steinebach, Sanil Bhatia, Finn K Hansen

  • A Facile Protocol for C(sp)-C(sp) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands.

    ChemMedChem

    Authors: Anita Maksutova, Thomas M Geiger, Lorenzo Cianni, Dominika E Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D Hartmann, Jan Krönke, Izidor Sosič, Radosław P Nowak, Michael Gütschow, Christian Steinebach

  • Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.

    Molecular cell

    Authors: Mikołaj Słabicki, Jiho Park, Radosław P Nowak, Shourya S Roy Burman, Jesse Pellman, Charles Zou, Hlib Razumkov, Jeannie Carreiro, Simran Rastogi, Anna Goldstein, Marek M Nagiec, Katherine A Donovan, Jianwei Che, Moritz Hunkeler, Qixiang Geng, Chi-Lin Hsu, Megha Lakshminarayan, Chelsea Shu, Rebecca L Zon, Zuzanna Kozicka, Paul M C Park, Jonathan M Tsai, Hojong Yoon, Lyn H Jones, Adam S Sperling, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert

All publications by Prof. Dr. Radoslaw Nowak