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Prof. Dr. Radosław P. Nowak

Member

Institute of Structural Biology

BMZ I, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn

radoslaw.nowak@uni-bonn.de

Website

Our mission is to explore therapeutic potential of small molecule induced proximity in inflammation and cancer. The laboratory focuses on targeted protein degradation, discovery and mechanistic characterization of novel molecular glues/induced proximity and development of technology for exploration of gain of function pharmacology.

Institut für Strukturbiologie, Uniklinik Bonn

Recent publications

  • Systematic Targeting of Protein Complexes with Molecular COUPLrs.

    Cancer discovery

    Authors: Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, Natalie Shannon Nordenfelt, Nicholas Chen, Christine Lee, Stefan T Kaluziak, Elizabeth M Codd, Samay Trivedi, Magdy Gohar, Giovan McKnight, Dawn R Mitchell, Maolin Ge, Chengzhuo Gao, Zavontae Holmes, Wenxin Yang, Abigail Elizabeth Smith, Alexander Daniel Carlin, Matthew J Lazarov, Sufian Moawiyah Ibrahim, Mariko Takahashi, Siwen Zhang, Herman Xin Yang Leong, Hector Martinez Luna, Reilly Stevens, Paul Strickland Mullin, Anastasia Ignashkina, Zander Chearavanont, Kim Emonds, George Popoola, Idris A Barakat, Maristela L Onozato, Mohammed Mahamdeh, Toshio Fujino, Jan Gerhartz, Emily E Ackerman, Huan Yee Koh, Vivek Naranbhai, Hyuk-Soo Seo, Sirano Dhe-Paganon, Zhen-Yu Jim Sun, Gregory J Heffron, Aaron N Hata, Roy Jason Soberman, Radoslaw P Nowak, Christopher J Ott, Brian B Liau, A John Iafrate, Liron Bar-Peled

  • Targeting Histone Acetyltransferases EP300/CBP by Novel Proline-Based PROTAC Degraders.

    ACS medicinal chemistry letters

    Authors: Kathrin Tan, Melina Vogt, Katerina Schaal, Swapna Swapna, Thomas M Geiger, Ina Dressel, Radosław P Nowak, Sanil Bhatia, Finn K Hansen

  • Activating p53 with a mutant-specific small molecule.

    Nature communications

    Authors: Xijun Zhu, Woong Sub Byun, Dominika Ewa Pieńkowska, Kha The Nguyen, Mengxiong Wang, Sabin A Nettles, Sai Gourisankar, Nick A Phillips, Jan Gerhartz, Qixiang Geng, Tian Qiu, Jianing Zhong, Zixuan Jiang, Roman C Sarott, Stephen M Hinshaw, Tinghu Zhang, Laura D Attardi, Radosław P Nowak, Nathanael S Gray

All publications by Prof. Dr. Radosław P. Nowak