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featured publications

  • A Facile Protocol for C(sp)-C(sp) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands.

    ChemMedChem

    Authors: Anita Maksutova, Thomas M Geiger, Lorenzo Cianni, Dominika E Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D Hartmann, Jan Krönke, Izidor Sosič, Radosław P Nowak, Michael Gütschow, Christian Steinebach

  • Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.

    Molecular cell

    Authors: Mikołaj Słabicki, Jiho Park, Radosław P Nowak, Shourya S Roy Burman, Jesse Pellman, Charles Zou, Hlib Razumkov, Jeannie Carreiro, Simran Rastogi, Anna Goldstein, Marek M Nagiec, Katherine A Donovan, Jianwei Che, Moritz Hunkeler, Qixiang Geng, Chi-Lin Hsu, Megha Lakshminarayan, Chelsea Shu, Rebecca L Zon, Zuzanna Kozicka, Paul M C Park, Jonathan M Tsai, Hojong Yoon, Lyn H Jones, Adam S Sperling, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert

  • Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6.

    RSC medicinal chemistry

    Authors: Silas L Wurnig, Maria Hanl, Thomas M Geiger, Shiyang Zhai, Ina Dressel, Dominika E Pieńkowska, Radosław P Nowak, Finn K Hansen

  • An engineered cereblon optimized for high throughput screening and molecular glue discovery.

    Cell chemical biology

    Authors: Henry J Bailey, Jonathan Eisert, Rubina Kazi, Jan Gerhartz, Dominika Ewa Pieńkowska, Ina Dressel, Joshua Vollrath, Ivan Kondratov, Tetiana Matviyuk, Nataliya Tolmachova, Varun Jayeshkumar Shah, Giulio Giuliani, Thorsten Mosler, Thomas M Geiger, Ana M Esteves, Sandra P Santos, Raquel L Sousa, Tiago M Bandeiras, Eva-Maria Leibrock, Ulrike Bauer, Birgitta Leuthner, Julian D Langer, Ansgar A Wegener, Radosław P Nowak, Fiona J Sorrell, Ivan Dikic

  • Activating p53 with a Mutant-Specific Small Molecule.

    bioRxiv : the preprint server for biology

    Authors: Xijun Zhu, Woong Sub Byun, Dominika Ewa Pieńkowska, Kha The Nguyen, Jan Gerhartz, Qixiang Geng, Tian Qiu, Jianing Zhong, Zixuan Jiang, Mengxiong Wang, Roman C Sarott, Stephen M Hinshaw, Tinghu Zhang, Laura D Attardi, Radosław P Nowak, Nathanael S Gray

  • A double whammy for KEAP1.

    Cell chemical biology

    Authors: Jan Gerhartz, Radosław P Nowak

  • Targeted protein degradation: from mechanisms to clinic.

    Nature reviews. Molecular cell biology

    Authors: Jonathan M Tsai, Radosław P Nowak, Benjamin L Ebert, Eric S Fischer