Skip to main content

Publications

featured publications

  • Systematic Targeting of Protein Complexes with Molecular COUPLrs.

    Cancer discovery

    Authors: Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, Natalie Shannon Nordenfelt, Nicholas Chen, Christine Lee, Stefan T Kaluziak, Elizabeth M Codd, Samay Trivedi, Magdy Gohar, Giovan McKnight, Dawn R Mitchell, Maolin Ge, Chengzhuo Gao, Zavontae Holmes, Wenxin Yang, Abigail Elizabeth Smith, Alexander Daniel Carlin, Matthew J Lazarov, Sufian Moawiyah Ibrahim, Mariko Takahashi, Siwen Zhang, Herman Xin Yang Leong, Hector Martinez Luna, Reilly Stevens, Paul Strickland Mullin, Anastasia Ignashkina, Zander Chearavanont, Kim Emonds, George Popoola, Idris A Barakat, Maristela L Onozato, Mohammed Mahamdeh, Toshio Fujino, Jan Gerhartz, Emily E Ackerman, Huan Yee Koh, Vivek Naranbhai, Hyuk-Soo Seo, Sirano Dhe-Paganon, Zhen-Yu Jim Sun, Gregory J Heffron, Aaron N Hata, Roy Jason Soberman, Radoslaw P Nowak, Christopher J Ott, Brian B Liau, A John Iafrate, Liron Bar-Peled

  • Targeting Histone Acetyltransferases EP300/CBP by Novel Proline-Based PROTAC Degraders.

    ACS medicinal chemistry letters

    Authors: Kathrin Tan, Melina Vogt, Katerina Schaal, Swapna Swapna, Thomas M Geiger, Ina Dressel, Radosław P Nowak, Sanil Bhatia, Finn K Hansen

  • Activating p53 with a mutant-specific small molecule.

    Nature communications

    Authors: Xijun Zhu, Woong Sub Byun, Dominika Ewa Pieńkowska, Kha The Nguyen, Mengxiong Wang, Sabin A Nettles, Sai Gourisankar, Nick A Phillips, Jan Gerhartz, Qixiang Geng, Tian Qiu, Jianing Zhong, Zixuan Jiang, Roman C Sarott, Stephen M Hinshaw, Tinghu Zhang, Laura D Attardi, Radosław P Nowak, Nathanael S Gray

  • Recruiting without destroying.

    Nature chemical biology

    Authors: Dominika Ewa Pieńkowska, Radosław Piotr Nowak

  • The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

    Cell

    Authors: Ngee Kiat Chua, Tania J González-Robles, Cameron J Reddington, Jane Dudley-Fraser, Richard W Birkinshaw, Jiru Han, Ashleigh Solano, Soon Wei Wong, Tomasz Kochańczyk, Joshua J Peter, Mark A Nakasone, Florian Aust, Jacob Munro, Yeh Huei Tong, Julie Iskander, Waruni Abeysekera, Alex Garnham, Hannah Huckstep, Matthew E Ritchie, Ingrid Wertz, Sarah Hymowitz, Sharad Kumar, Ron C Conaway, Gilbert G Privé, Alex N Bullock, Jeffrey J Babon, Rachel E Klevit, Sonja Lorenz, Alessio Ciulli, Eric S Fischer, Nicolas H Thomä, Radosław P Nowak, Brenda A Schulman, Michael Rapé, Katrin Rittinger, Julia K Pagan, Melanie Bahlo, Joel P Mackay, Peter D Mace, Christopher D Lima, Ronald T Hay, David Komander, Bernhard C Lechtenberg, Claudio A P Joazeiro, Michele Pagano, Kay Hofmann, Rebecca Feltham

  • Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies.

    Journal of medicinal chemistry

    Authors: Shiyang Zhai, Marie Kemkes, Cindy-Esther Kponomaizoun, Jan Gerhartz, Felix Feller, Jia-Wey Tu, Dominika Ewa Pieńkowska, Julian Schliehe-Diecks, Ina Dressel, Michael Gütschow, Radosław P Nowak, Christian Steinebach, Sanil Bhatia, Finn K Hansen

  • A Facile Protocol for C(sp)-C(sp) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands.

    ChemMedChem

    Authors: Anita Maksutova, Thomas M Geiger, Lorenzo Cianni, Dominika E Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D Hartmann, Jan Krönke, Izidor Sosič, Radosław P Nowak, Michael Gütschow, Christian Steinebach

  • Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.

    Molecular cell

    Authors: Mikołaj Słabicki, Jiho Park, Radosław P Nowak, Shourya S Roy Burman, Jesse Pellman, Charles Zou, Hlib Razumkov, Jeannie Carreiro, Simran Rastogi, Anna Goldstein, Marek M Nagiec, Katherine A Donovan, Jianwei Che, Moritz Hunkeler, Qixiang Geng, Chi-Lin Hsu, Megha Lakshminarayan, Chelsea Shu, Rebecca L Zon, Zuzanna Kozicka, Paul M C Park, Jonathan M Tsai, Hojong Yoon, Lyn H Jones, Adam S Sperling, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert

  • Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6.

    RSC medicinal chemistry

    Authors: Silas L Wurnig, Maria Hanl, Thomas M Geiger, Shiyang Zhai, Ina Dressel, Dominika E Pieńkowska, Radosław P Nowak, Finn K Hansen

  • An engineered cereblon optimized for high throughput screening and molecular glue discovery.

    Cell chemical biology

    Authors: Henry J Bailey, Jonathan Eisert, Rubina Kazi, Jan Gerhartz, Dominika Ewa Pieńkowska, Ina Dressel, Joshua Vollrath, Ivan Kondratov, Tetiana Matviyuk, Nataliya Tolmachova, Varun Jayeshkumar Shah, Giulio Giuliani, Thorsten Mosler, Thomas M Geiger, Ana M Esteves, Sandra P Santos, Raquel L Sousa, Tiago M Bandeiras, Eva-Maria Leibrock, Ulrike Bauer, Birgitta Leuthner, Julian D Langer, Ansgar A Wegener, Radosław P Nowak, Fiona J Sorrell, Ivan Dikic